Factors associated with the depression status of Chinese parents who have lost their only child.

Aim: This study aimed to assess the risk factors for depression among parents who have lost their only child (PLOCs).

Methods: We used a cross-sectional survey to reveal the risk factors of depression among PLOCs. Multi-stage, stratified, cluster sampling was used to recruit the participants.

[Spatial-temporal Distribution and Evolution Characteristics of Air Pollution in Beijing-Tianjin-Hebei Region Based on Long-term "Ground-Satellite" Data].

This study aimed to promote the coordinated development of regional social economy and ecological environment, build a better living environment, accurately prevent and control pollution, and carry out in-depth surveys and general surveys of air pollution in Beijing, Tianjin, and Hebei. Based on 6 years (June 2014 to December 2019) of ground environmental observation data and satellite data from 2000 to 2019, the distribution characteristics and evolution trend of air pollution in different time and spatial scales were analyzed. The results showed that:① according to the daily average concentration of PM at the sites, the pollution in the Beijing-Tianjin-Hebei region showed the characteristics of more days, heavy levels, and overall improvement.

The Reproductive Toxicity of Monosodium Glutamate by Damaging GnRH Neurons Cannot Be Relieved Spontaneously Over Time.

Objective: The present study aims to evaluate the effect of monosodium glutamate on testicular spermatogenesis in mice from the perspective of the hypothalamic-pituitary-testicular axis and whether this destructive effect is alleviated with time.

Methods: Neonatal mice were randomly divided into a monosodium glutamate (MSG) group and a control group, just below the interscapular region after birth with 10 µL MSG to deliver 4 mg/g (body mass), or with equivalent volumes of 0.9% saline.

Factors Affecting Artificial Insemination Pregnancy Outcome.

Objective: The aim of the present study was to explore related clinical pregnancy outcome factors in intrauterine insemination (IUI).

Materials And Methods: The clinical data of 3984 IUI cycles in 1862 couples experiencing infertility who attended the Reproductive Center of Binzhou Medical University Hospital between July 2006 and July 2017 were retrospectively analyzed. Female and male patient age, endometrial thickness (EMT), the post-wash total motile sperm count (PTMC), artificial insemination timing, insemination frequency, and ovarian stimulation protocols were compared between the study's pregnant group and non-pregnant group in order to explore any correlation.

[Characteristics of Spatial and Temporal Evolution and Investigation of Air Pollution in Guangdong-Hong Kong-Macao Greater Bay Area Based on Ground-Space Observation Data].

The temporal and spatial distribution characteristics, evolution trend and potential climatic effects of air pollution in the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) were analyzed on different time scales and spatial spaces, based on ground environment observation data from June 2014 to December 2018 and satellite remote sensing inversion products from 2000 to 2018. The results show that:① From the in-situ observed daily average concentration of PM, good or mild to moderate pollution occurred in January, February, October, November, and December every year, and the rest of the time was excellent. ② Based on the annual average PM concentration obtained by satellite for the past 20 years, the spatial characteristics showed that the external radiation is centered on Guangzhou and Foshan.

Effect of BMI on blood value of patients on HCG day with IUI treatment.

Background: This study aims to analyze the effect of the body mass index (BMI) on E, P and LH values in females who received intrauterine insemination (IUI) treatment on human chorionic gonadotropin (HCG) day.

Methods: A total of 2319 cycles of IUI-assisted pregnancy treatment were selected in our hospital. Based on the BMI, female infertility patients are divided into three groups: normal weight group, overweight and obese group.

[Research on the Pollution Characteristics and Causality of Haze-sand Air Pollution in Beijing in Spring].

From May 3 to 5, 2017, a special heavy pollution event occurred in Beijing. The meteorological conditions associated with the heavy pollution were relatively special, so the pollution forms and causes were studied. The general characteristics of this pollution event were obtained based on data from 35 environmental monitoring stations in Beijing.

Prophylactic treatment with MSC-derived exosomes attenuates traumatic acute lung injury in rats.

The mesenchymal stem cell (MSC) is a potential strategy in the pretreatment of traumatic acute lung injury (ALI), a disease that causes inflammation and oxidative stress. This study aimed to investigate whether MSC-exosomal microRNA-124-3p (miR-124-3p) affects traumatic ALI. Initially, a traumatic ALI rat model was established using the weight-drop method.

[Influence of Mountain Valley Breeze and Sea Land Breeze in Winter on Distribution of Air Pollutants in Beijing-Tianjin-Hebei Region].

To reveal the effect of Mountain Valley Breeze (MVB) and Sea Land Breeze (SLB) in winter on the spatial-temporal distribution of air pollutants in the Beijing-Tianjin-Hebei region, hourly data from Automatic Weather Stations (AWS) and hourly air pollutant concentration data in December 2016 from the China National Environmental Monitoring Center were used to calculate the average wind vector fields and PM concentration fields. The change rule of MVB and SLB and its influence on the distribution of PM concentration were analyzed. The prevailing factor for the MVB days was the southerly wind (valley wind) in the Beijing-Tianjin-Hebei region from noon to afternoon, this valley wind transports air pollutants from the eastern areas of the Taihang Mountains and southwestern areas of Beijing northward.

[Dynamic changes of pH2AX expression in the reversibility of mouse testicular reproductive function impaired by single heat stress].

Objective: To investigate the role of pH2AX in the reversibility of mouse testicular reproductive function impaired by single heat stress.

Methods: Twenty-four C57 male mice were randomly divided into heat stress and control groups and immersed in water at 43℃ and 25℃, respectively, for 15 minutes. At 1, 7, and 14 days of heat exposure, all the mice were sacrificed and their testis tissues collected for determining the apoptosis of the germ cells by TUNEL and measuring the expression level of the pH2AX protein by immunohistochemistry and Western blot.

Arcuate nucleus neurons are not essential for the preprandial peak in plasma ghrelin after neonatal monosodium glutamate treatment.

The aim of the present study was to determine whether arcuate nucleus (ARC) lesions affect the ghrelin level in the plasma and the stomach in monosodium glutamate (MSG)‑treated mice. The aim of the present study was to investigate whether the ARC was destroyed in mice treated neonatally with MSG, and whether the ARC lesions affect the ghrelin level in the plasma and lipid mobilization in MSG‑treated mice. The results revealed that MSG led to a marked reduction in ARC cresyl violet staining, tyrosine hydroxylase-immunoreactive (IR) neurons and neuropeptide Y‑IR fibers, compared with saline controls.

Corneal confocal microscopy as a non-invasive test to assess diabetic peripheral neuropathy.

Objective: To evaluate the efficacy of corneal confocal microscopy (CCM) as a non-invasive test to assess diabetic peripheral neuropathy in Chinese patients diagnosed with type 2 diabetes.

Research Design And Methods: Diabetic distal symmetric polyneuropathy (DSPN) and its severity degrees were assessed based on the modified Toronto diagnostic criteria in 128 patients with type 2 diabetes (No DSPN [n = 49], mild DSPN [n = 43], moderate-to-severe DSPN [n = 36]) and 24 age-matched controls. CCM was also examined in all enrolled subjects.

Expanded alleles of the gene are related to unexplained recurrent miscarriages.

Up to 50% of recurrent miscarriage cases in women occur without an underlying etiology. In the current prospective case-control study, we determined the impact of CGG trinucleotide expansions of the fragile-X mental retardation 1 () gene in 49 women with unexplained recurrent miscarriages. Case group consisted of women with two or more unexplained consecutive miscarriages.

Diagnostic accuracy of urine HE4 in patients with ovarian cancer: a meta-analysis.

Urine HE4 has been reported as the potential novel diagnostic biomarker for ovarian cancer in several studies, but their results were inconsistent. Therefore, we conducted a systematic analysis to evaluate the diagnostic value of urine HE4 in detecting ovarian cancer. A comprehensive electronic and manual search was conducted for relevant literatures through several databases up to May 5, 2016.

Enhanced therapeutic efficacy and amelioration of cisplatin-induced nephrotoxicity by quercetin in 1,2-dimethyl hydrazine-induced colon cancer in rats.

Objective: The aim of quercetin treatment in combination of cisplatin (CP)-induced nephrotoxicity as well on 1,2-dimethyl hydrazine (DMH)-induced colon cancer.

Materials And Methods: In this study, animals are exposed to DMH hydrochloride to induce colon cancer. In these groups, nephrotoxicity was assessed with the help of blood urea nitrogen, urea, and creatinine.

Arctigenin induces apoptosis in colon cancer cells through ROS/p38MAPK pathway.

Purpose: In the current study the antiproliferative effect of arctigenin, plant lignin, was evaluated on human colon cancer cell line HT-29. Furthermore, attempts were made to explore the signaling mechanism which may be responsible for its effect.

Methods: Cell growth inhibition was assessed by MTT and LDH assays.

Inhibition of γ-secretase by retinoic acid chalcone (RAC) induces G2/M arrest and triggers apoptosis in renal cell carcinoma.

The present study was devised to investigate the effect of RAC on inhibition of cell proliferation and apoptosis of renal carcinoma cells. MTT assay and flow cytometry analysis were used to determine cell proliferation and apoptosis along with cell cycle examination. Western blot analysis and immunohistochemistry were used for the detection of expression levels of Notch1 and Jagged1 in renal cell carcinoma (RCC) and normal kidney tissues.

[Prognostic analysis of 336 patients with chronic severe hepatitis B].

Objective: To investigate the risk factors related to outcome of chronic severe hepatitis B.

Methods: A total of 336 consecutive patients with chronic severe hepatitis B (CSHB) were analysed retrospectively. According to the outcome, objects were divided into survival group (n = 137) and death group(n = 199), then to observe the differences between them in respect to age, sex, family history, prothrombin activity (PTA), complications including ascites, infection, electrolyte disturbance, upper gastrointestinal bleeding, hepatic encephalopathy, hepatorenal syndrome and the corresponding quantity of complications in each individual, antivirus therapy, artificial liver support system (ALSS) therapy, and alprostadil therapy.

Sexual mixing patterns among social networks of HIV-positive and HIV-negative Beijing men who have sex with men: a multilevel comparison using roundtable network mapping.

Men who have sex with men (MSM) are of immediate concern in China's HIV epidemic. In 2008, approximately 2.5-6.