Publications by authors named "Qing-Zhong Xiao"
Cancer is a genetic disease caused by alterations in genome and epigenome and is one of the leading causes for death worldwide. The exploration of disease development and therapeutic strategies at the genetic level have become the key to the treatment of cancer and other genetic diseases. The functional analysis of genes and mutations has been slow and laborious.
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- Xin-Ji-Er-Kang (XJEK), a traditional Chinese medicine, shows protective effects against heart diseases, particularly in myocardial ischemia-reperfusion (MIR) injury, but its specific components and mechanisms remain unclear.
- A study analyzed key compounds in XJEK and their effects on MIR injury using high-resolution mass spectrometry and bioinformatics, along with testing in mice over six weeks, focusing on cardiac function and apoptosis levels.
- Results indicated that matrine, found in Sophora flavescens alkaloids, is the main active ingredient in XJEK, which enhances heart function and reduces cell death by activating the JAK2/STAT3 signaling pathway.
Copper is a trace element necessary for the normal functioning of organisms, but excessive copper contents may be toxic to the heart. The goal of this study was to investigate the role of excessive copper accumulation in mitochondrial damage and cell apoptosis inhibition. In vivo, the heart copper concentration and cardiac troponin I (c-TnI) and N-terminal forebrain natriuretic peptide (NT-pro-BNP) levels increased in the copper-laden model group compared to those of the control group.
View Article and Find Full Text PDFPlatelet mitophagy is a major pathway involved in the clearance of injured mitochondria during hemostasis and thrombosis. Prohibitin 2 (PHB2) has recently emerged as an inner mitochondrial membrane receptor involved in mitophagy. However, the mechanisms underlying PHB2‑mediated platelet mitophagy and activation are not completely understood.
View Article and Find Full Text PDFBackground: Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF.
Method: In this study, we present a "system to system" (S2S) mode.
[Distribution and drug-resistance of 3 500 gram-negative bacteria in Guangzhou].
Di Yi Jun Yi Da Xue Xue Bao
February 2005
Objective: To investigate the distribution and drug-resistance of the common gram-negative bacteria in Guangzhou.
Methods: From July 2001 to August 2003, the resistance of 3 500 strains of common gram-negative bacteria isolated from 13 hospitals in Guangzhou to 15 to 21 antibiotics was determined by standard Kirby-Bauer method according to the guidelines of the National Committee for Clinical Laboratory Standards (NCCLS, 2000). WHONET-5 software was used to analyze the data.