Publications by authors named "Qing-Zheng Zhang"
Background: Early detection of nasopharyngeal carcinoma (NPC) poses a significant challenge. The absence of highly sensitive and specific diagnostic biomarkers for nasopharyngeal carcinoma contributes to the unfavourable prognosis of NPC patients. Here, we aimed to establish a non-invasive approach for detecting NPC using circulating cell-free DNA (cfDNA).
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- Hyperuricaemia (HUA) is a metabolic disorder linked to high uric acid levels and associated health risks, with traditional treatments often causing side effects.
- Fangyukangsuan granules, a natural product, were found to bind to xanthine oxidase (XOD), crucial for uric acid metabolism, leading to significant reductions in serum uric acid and related biochemical indices in HUA-model rats.
- Additionally, these granules positively influenced intestinal microbiota by altering its structure, suggesting potential therapeutic benefits for managing HUA and improving gut health.
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- Liver cirrhosis (LC) significantly increases the risk of developing hepatocellular carcinoma (HCC), yet current surveillance methods for HCC in LC patients are not very effective.
- This study involved over 4,000 patients with liver cirrhosis and nearly 600 HCC cases across multiple hospitals in China, where researchers developed a screening model called PreCar Score based on cell-free DNA (cfDNA) features.
- The PreCar Score showed better sensitivity in detecting early HCC compared to traditional methods, and when combined with ultrasound (US), it further improved early detection rates, making it a promising tool for regular HCC screening in high-risk patients.
Background: Hepatocellular carcinoma (HCC) generally arises from a background of liver cirrhosis (LC). Patients with cirrhosis and suspected HCC are recommended to undergo serum biomarker tests and imaging diagnostic evaluation. However, the performance of routine diagnostic methods in detecting early HCC remains unpromising.
View Article and Find Full Text PDFPurpose: Intratumoral hepatitis B virus (HBV) integrations and mutations are related to hepatocellular carcinoma (HCC) progression. Circulating cell-free DNA (cfDNA) has shown itself as a powerful noninvasive biomarker for cancer. However, the HBV integration and mutation landscape on cfDNA remains unclear.
View Article and Find Full Text PDFThe speckled wood-pigeon, Columba hodgsonii, is mainly distributed in Bhutan, China, India, Laos, Myanmar, Nepal, Pakistan, and Thailand. Although there are several studies on birds in the family Columbidae, no study has focused on C. hodgsonii, a member of this family.
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