Publications by authors named "Qing-Yu Guo"
Article Synopsis
- * Researchers tested the effects of different concentrations of lipopolysaccharide (LPS) on cell viability, inflammation, and bone-forming abilities using various assays.
- * The findings reveal that low LPS concentrations stimulate DePDLSCs while high levels inhibit their function, and that interference with the PI3K-AKT signaling pathway can alleviate some of these negative effects, offering insights for potential treatments of apical periodontitis.
Objective: This study aimed to retrospectively describe the unplanned retreatment of dental general anesthesia (DGA) in children with severe early childhood caries (S-ECC) and explore potential factors that may influence the outcome of DGA treatment.
Methods: Medical records of children with S-ECC who received DGA treatment were screened, and necessary data were extracted. The Kaplan-Meier method and Cox proportional hazards model were used to estimate the DGA survival rate and explore the potential factors affecting the success rate of DGA treatment.
Article Synopsis
- - This study evaluated the long-term survival rates and risk factors for failure of pulpectomy treatments in children with severe early childhood caries (S-ECC) performed under dental general anesthesia between 2014 and 2019.
- - Out of 381 children, the overall 35-month survival rate for the treatments was 38.5%, with anterior teeth showing better survival (52.9%) compared to molars (31.1%); older children had a higher risk of treatment failure.
- - The findings suggest that while pulpectomy can be a viable option to retain primary teeth affected by extensive caries, molar treatments are more prone to failure compared to anterior teeth, and survival rates tend to decrease over
Relationship Between Acyl and Desacyl Ghrelin Levels with Insulin Resistance and Body Fat Mass in Type 2 Diabetes Mellitus.
Diabetes Metab Syndr Obes
September 2022
Purpose: Although strong evidence suggests that ghrelin plays an important role in regulating energy balance, the effects of acylated ghrelin (AG) and deacylated ghrelin (DAG) on fat mass are largely undefined. This study aimed to investigate the differential associations of both forms of ghrelin with insulin resistance and body fat mass in patients with type 2 diabetes mellitus (T2DM).
Patients And Methods: A total of 162 patients with type 2 diabetes were recruited and classified based on BMI and visceral fat area (VFA) as VFA normal group (n = 78), normal-BMI VFA obesity group (n = 20) and high-BMI VFA obesity group (n = 64).
Background: Time in range (TIR) is advocated as key metric of glycemic control and is reported to be associated with microvascular complications of diabetes. Sudomotor dysfunction is among the earliest detectable diabetic peripheral neuropathy (DPN). We set about to research the relationship between TIR including overnight TIR and sudomotor function detected by SUDOSCAN with the intention of exploring the correlation of TIR including overnight TIR and early DPN in type 1 diabetes (T1D).
View Article and Find Full Text PDFAims: To explore the association between dynamic islet secretory function and TIR (time in range), a new valuable metric of glycemic control in type 2 diabetes (T2D).
Methods: In this observational study 256 patients with type 2 diabetes were included and continuous glucose monitoring system (CGMS) were applied to monitor blood glucose and also the calculation of TIR [the time spent in an individual's target glucose range (usually 3.9-10 mmol/L)].
Background: Time in range (TIR), as a novel metric for glycemic control, has robust relevance with diabetic complications. Diabetic peripheral neuropathy (DPN) is characterized by sudomotor dysfunction.
Aim: To explore the relationship between TIR obtained from continuous glucose monitoring (CGM) and sudomotor function detected by SUDOSCAN in subjects with type 2 diabetes.
Article Synopsis
- Injuries to primary teeth can impact a child's appearance, function, and mental health, as well as the development of their permanent teeth, but there is limited evaluation of dentists' knowledge on this topic in China.
- A survey conducted with 394 dentists revealed a 66% correct response rate regarding treatment knowledge for dental trauma, with specific areas like enamel fracture being well understood, while complicated crown-root fractures were less so.
- The study concluded that improving dental trauma education for dentists is crucial, highlighting that factors like specialist training and educational experience positively affect knowledge on the subject.
Background: Layering techniques for direct composite resin restorations might be complicated for inexperienced learners, as a number of materials and instruments are required at each step. The present study aimed to compare and assess the teaching effect of step-by-step and all-in-one teaching methods in layering techniques for direct composite resin restorations among undergraduate dental students.
Methods: A total of 68 junior dental students participated in this study, which was a prospective and single-blind trial.
Article Synopsis
- Traumatic dental injuries (TDIs) are a significant global dental health issue, and a study aimed to analyze the trends in TDI research over the last 20 years through a bibliometric approach.
- A total of 2,627 articles were examined, with a noticeable increase in publications, primarily from developed countries, especially Brazil, with "Dental Traumatology" being the leading journal.
- The research focused largely on treatment strategies for TDIs, particularly for permanent teeth, but highlighted a shortage of high-quality studies and a lack of emphasis on prevention and primary dentition.
The Relationship Between β-cell Function Indices and Sudomotor Function in Chinese Patients with Type 2 Diabetes.
Exp Clin Endocrinol Diabetes
August 2021
Purpose: SUDOSCAN, a new non-invasive, quick, sensitive and quantitative technique, has been developed to detect diabetic peripheral neuropathy, and the latter is believed to be correlated with impaired β-cell function. The purpose of the present study was to investigate the associations between β-cell function indices and sudomotor function in Chinese type 2 diabetes.
Methods: A total of 266 Chinese patients with type 2 diabetes were enrolled.
A meta-analysis of emotional disorders as possible risk factors for chronic periodontitis.
Medicine (Baltimore)
July 2018
The aim of the present meta-analysis was to evaluate scientific evidence on the association between emotional disorder (depression and anxiety) and chronic periodontitis. An overall electronic literature search in PubMed, ISI Web of Science, Cochrane Library, and China National Knowledge Infrastructure was undertaken up to November 2017. Newcastle-Ottawa scale was applied to ascertain the validity of each eligible study.
View Article and Find Full Text PDF[Prevalence survey of immature permanent tooth trauma about the clinical visiting and prognosis in Xi'an schoolchildren].
Hua Xi Kou Qiang Yi Xue Za Zhi
June 2018
Article Synopsis
- The study examines how schoolchildren in Xi'an are affected by trauma to their immature permanent teeth and looks into the factors influencing their prognosis.
- A survey of 4,013 pupils revealed that only 38.2% of those with dental trauma sought clinical help, with gender and type of trauma being key factors in this decision.
- Results showed that the prognosis for children who did visit a clinic was poorer (35.4%) compared to those who did not seek help (20.6%), indicating a significant need for increased awareness and intervention.
[Prevalence survey of dental trauma to immature permanent teeth in Xi'an schoolchildren].
Hua Xi Kou Qiang Yi Xue Za Zhi
April 2018
Article Synopsis
- The study examined the prevalence, distribution, and causes of immature permanent tooth trauma among schoolchildren in Xi'an, aiming to support health administration decision-making.
- A sample of 4,013 pupils was surveyed, with findings showing a 10.5% prevalence of dental trauma, predominantly in children aged 7-9, peaking at 8 years old.
- The main cause of trauma was falls (50.9%), followed by crashes (36.0%), with the maxillary incisors being the most commonly affected teeth (75.4%).
A novel, yet effective method for identifying DNA-binding modes of [Ru(bpy)(2)dmt](2+) (where bpy = 2,2'-bipyridine and dmt = 2,3-dimethyl-1,4,8,9-tetra-aza-triphenylene) on an indium tin oxide electrode has been successfully developed by introducing Cu(2+) ion and ethylenediaminetetraacetic acid. The results from emission spectra and fluorescence microscopic images suggested that [Ru(bpy)(2)dmt](2+) not only associates with Cu(2+) ion in both the absence and presence of DNA but also shows strong affinity with DNA in the presence of Cu(2+). Evidence for the strong binding of [Ru(bpy)(2)dmt](2+) to DNA was determined from the interface studies using electrochemical methods.
View Article and Find Full Text PDF[Detecting caries susceptible population in children with gtfB oligonucleotide probe].
Hua Xi Kou Qiang Yi Xue Za Zhi
August 2010
Objective: To establish a quick, exact and inexpensive method to detect caries susceptibility in children.
Methods: 125 caries free children, aged 3-4 years, were randomly sampled. A combination of polymerase chain reaction (PCR) and gtfB oligonucleotide probe hybridization method was used to detect Streptococcus mutans in saliva.
We examined the effects of phosphorothioate-modified antisense oligodeoxyribonucleotides (PS-ODN) targeted to mRNA transcribed from gtfB, which encodes synthesis of water-insoluble glucans in Streptococcus mutans. Treatment of S. mutans with 10 muM antisense PS-ODNs inhibited gtfB mRNA transcription, GtfB expression and water-insoluble glucan synthesis.
View Article and Find Full Text PDF[Screening and identification of metastasis-related gene expression in tongue carcinoma with cDNA microarray assay].
Hua Xi Kou Qiang Yi Xue Za Zhi
April 2006
Objective: To identify metastasis-associated genes in tongue carcinoma and to better understand the mechanism underlying tongue carcinoma metastasis. To compared mRNA expression profiles of two tongue carcinoma cell strains with high and low metastatic potentials using microarray technology.
Methods: Tca8113 and Tb cells were used as model systems to study the molecular mechanism of tumor metastasis.