Publications by authors named "Qing-You Xu"
Article Synopsis
- Obstructive sleep apnea syndrome (OSAS) is linked to chronic kidney disease primarily due to the damage caused by chronic intermittent hypoxia (CIH) and involves recurrent awakening during sleep.
- A study established an OSAS model through CIH exposure, revealing macrophage infiltration and a transition to myofibroblasts in the kidneys, contributing to renal fibrosis.
- Aldosterone's binding to the mineralocorticoid receptor (MR) was found to stimulate this transition and renal fibrosis under hypoxia, but blocking MR with eplerenone showed protective effects against renal injury.
Background: The unilateral ureteral obstruction (UUO) model not only induces renal interstitial fibrosis in the obstructed kidney but also induces injury in the contralateral kidney. We hypothesized that activation of the mineralocorticoid receptor (MR) may induce fibrosis in the early stage of UUO.
Methods: Thirty male Sprague-Dawley rats weighting 200 ± 10 g were used in this study and randomly divided into 3 groups: a UUO group, a UUO and eplerenone group, and a sham group.
[Effect of Huayu Jiedu Recipe on the Expressions of NLRP3, Caspasel, and IL-1 β in Kidneys of Obstructive Nephropathy Rats].
Zhongguo Zhong Xi Yi Jie He Za Zhi
April 2017
Objective To observe the effect of Huayu Jiedu Recipe (HJR) on the expressions of nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) , Caspase-1 , IL-1 β in kidneys of obstructive nephropathy rats. Methods Totally 40 clean grade SD rats were randomly divided into the sham-operation group (n =10) and the model group (n =30). The model of obstructive nephropa- thy was established by unilateral ureteral obstruction (UUO).
View Article and Find Full Text PDF[Effect of shenluotong decoction on renal interstitial fibrosis in rats with obstructive nephropathy].
Zhongguo Zhong Xi Yi Jie He Za Zhi
October 2014
Objective: To observe the effect of Shenluotong Decoction (SD) on serum levels of aldosterone, monocyte chemoattractant protein-1 (MCP-1), α-smooth muscle protein (α-SMA), and nuclear factor-KB (NF-κB) in obstructive nephropathy rats, and to explore the initial mechanism of SD for inhibiting renal interstitial fibrosis.
Methods: Totally 48 healthy Wistar rats were randomly divided into the sham-operation group (n =12) and the model group (n =36). Renal interstitial fibrosis rat model was established by unilateral ureteral obstruction (UUO).
[Effect of Shenluotong on secretion of ECM and expression of TGF-beta1 in rats mesangial cells of rats].
Zhongguo Zhong Yao Za Zhi
February 2005
Objective: To investigate the effect of Shenluotong on the expression of transforming growth factor-beta1 (TGF-beta1) and extracellular matrix (ECM) in Ang II-induced MCs.
Method: Fibronectin (FN) and collagen type IV (Col IV) of extracellular matrix were detected by enzyme-linked immunosorbent assay; the expression of TGF-beta1 mRNA were measured by semi-quantitative reverse transcription-polymerase chain reaction.
Result: A positive correlation between TGF-beta1 and ECM were found in the present study.