The blockage of Notch signalling promoted the generation of polymorphonuclear myeloid-derived suppressor cells with lower immunosuppression.

Myeloid-derived suppressor cells (MDSCs) mostly consisting of polymorphonuclear (PMN)-MDSCs and mononuclear MDSCs have been considered to play critical roles in immunosuppression, angiogenesis, invasion and metastases of various tumours. However, it is still unclear the regulated mechanisms underlying the generation and immunosuppression of two major MDSC subsets. Here, we report Notch signalling was inhibited significantly in tumour-bearing mouse MDSCs, in which PMN-MDSCs were the major population.

[Estimation of postmortem interval using FTIR spectroscopy in rats' cardiac muscle].

Objective: FTIR (Fourier transform infrared) spectroscopy was applied to observe the process of postmortem degradation in rats' cardiac muscle and provided a new method for the estimation of post-mortem interval (PMI).

Methods: The rats were sacrificed by cervical dislocation and the bodies were kept in a controlled environmental chamber set at (20 +/- 2) degrees C. The FTIR spectra was applied to measure the changes of different chemical group from rats' left ventricle muscle at the different time point postmortem.

[The correlation between postmortem interval and Fourier transform infrared spectra in rat's brain].

In the present study, FTIR spectroscopy was applied to observe the process of postmortem degradation in rat's brain and a lot of useful data for the estimation of postmortem interval (PMI) were provided. Sprague-Dawley male rats (weight 240 +/- 10 g) were chosen and sacrificed by cervical dislocation. The bodies were kept in a controlled environmental chamber set at (20 +/- 2) degrees C, and their brain cortex as the measuring sample which was extracted at 0, 12, 24, 48, 72, 96, 120, 144 and 168 h from the 8 rats.

[The changes of Fourier transform infrared spectroscopy in rat's brain].

Objective: To apply Fourier transform infrared (FTIR) spectroscopy to study the process of postmortem degradation of the rat brain and to provide a new way for the estimation of postmortem interval (PMI).

Methods: The rats were sacrificed by cervical dislocation and the bodies were kept in a controlled environmental chamber set at (30 +/- 2) degrees C. To measure the content of the chemical groups in postmortem rat brains at the different time points from 0 to 36 h using the FTIR spectrograph.