Publications by authors named "Qing-Yan Cui"
Article Synopsis
- DNA hydroxylation by Tet dioxygenases is common in embryonic stem cells and neurons, but its specific functions in living organisms are still unclear.
- Research shows that Tet1 is crucial for the proliferation of neural progenitor cells in the adult mouse brain, and mice without Tet1 have issues with learning and memory due to impaired neurogenesis in the hippocampus.
- In neural progenitor cells lacking Tet1, certain genes that promote cell proliferation are hypermethylated and downregulated, suggesting Tet1's role in epigenetically regulating these cells in the adult brain.
Cytosine methylation of genomic DNA controls gene expression and maintains genome stability. How a specific DNA sequence is targeted for methylation by a methyltransferase is largely unknown. Here, we show that histone H3 tails lacking lysine 4 (K4) methylation function as an allosteric activator for methyltransferase Dnmt3a by binding to its plant homeodomain (PHD).
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