Immobilization of engineered E. coli cells for asymmetric reduction of methyl acetoacetate to methyl-(R)-3-hydroxybutyrate.

The efficient asymmetric bio-synthesis of chiral β-hydroxy esters is of great importance for industrial production. In this work, a simple and productive engineered E.coli cell-immobilized strategy was applied for the asymmetric reduction of MAA to (R)-HBME with high enantioselectivity.

Prognostic nutritional index predicts prognosis in patients with metastatic nasopharyngeal carcinoma.

Objective: This study aimed to investigate the prognostic value of Onodera's prognostic nutritional index (PNI) in patients with metastatic nasopharyngeal carcinoma (NPC).

Methods: A total of 187 patients with metastatic NPC treated with cisplatin-based chemotherapy were retrospectively reviewed. The PNI was calculated using the following formula: serum albumin level (gram per liter) +0.

Pneumatic lithotripsy for ureterolithiasis: clinical analysis of 512 cases.

Objective: To investigate the therapeutic effects of pneumatic lithotripsy (PL) through ureteroscope in the treatment of ureterolithiasis.

Method: The clinical application of rigid ureteroscopy in 512 cases were retrospectively analyzed.

Results: Among the 512 cases, 486 had satisfactory therapeutic effects with the success rate of 94.