Chemical and Bioactivity Diversity of 2-(2-Phenylethyl)chromones in Agarwood: A Review.

2-(2-Phenylethyl)chromone derivatives are regarded as key components in agarwood. An oxygen-containing heterocycle with a benzoannelated γ-pyrone moiety form the bioactive core of 2-(2-phenylethyl)chromones. With different substituents and positions, 2-(2-phenylethyl)chromone derivatives exhibit diverse biological properties, such as antioxidant, antimicrobial, neuroprotective, anti-inflammatory, and acetylcholinesterase inhibitory activities.

Dual Recombining-out System for Spatiotemporal Gene Expression in .

Specific recording, labeling, and spatiotemporal manipulating neurons are essential for neuroscience research. In this study, we developed a tripartite spatiotemporal gene induction system in , which is based on the knockout of two transcriptional terminators (stops in short) by two different recombinases FLP and CRE. The recombinase sites (P and ) flanked stops after a ubiquitous promoter terminate transcription of target genes.

GCY-35/GCY-36-TAX-2/TAX-4 Signalling in O Sensory Neurons Mediates Acute Functional Ethanol Tolerance in Caenorhabditis elegans.

Ethanol is a widely used beverage and abused drug. Alcoholism causes severe damage to human health and creates serious social problems. Understanding the mechanisms underlying ethanol actions is important for the development of effective therapies.