Targeted isolation of lignans and triterpenoids from kadsura coccinea by molecular networking and anti-RA-FLS activity.

In this study, six compounds (four triterpenoids named heilaohutriterpenes A-D and two lignans name heilaohusuins F and G) together with 21 known compounds were isolated from roots of Kadsura coccinea (Lem.) A. C.

Heilaohuacid G, a new triterpenoid from Kadsura coccinea inhibits proliferation, induces apoptosis, and ameliorates inflammation in RA-FLS and RAW 264.7 cells via suppressing NF-𝜅B pathway.

Heilaohu, the roots of Kadsura coccinea, has been used in Tujia ethnomedicine to treat rheumatic arthritis (RA). Heilaohuacid G (1), a new 3,4-seco-lanostane type triterpenoid isolated from the ethanol extract of Heilaohu, whose structure was determined using HR-ESI-MS data, NMR spectroscopic analyses, and ECD calculations. In this study, our purpose is to elucidate the mechanisms of Heilaohuacid G in the treatment of RA by inhibited proliferation of rheumatoid arthritis-fibroblastoid synovial (RA-FLS) cells and inhibited the inflammatory reactions in LPS-induced RA-FLS and RAW 264.

Triterpenoids From With Their Anti-inflammatory and Inhibited Proliferation of Rheumatoid Arthritis-Fibroblastoid Synovial Cells Activities.

One new 3,4--17,13-friedo-lanostane triterpenoid heilaohuacid A (), one new 3,4--17,14-friedo-lanostane triterpenoid heilaohuacid B (), five new 3,4-lanostane triterpenoids heilaohuacids C-D () and heilaohumethylesters A-C (), one new 3,4--cycloartane triterpenoid heilaohuacid E (), and one new -lanostane triterpenoid heilaohuacid F (), together with twenty-two known analogues (), were isolated from heilaohu. Their structures were determined using HR-ESI-MS data, 1D and 2D NMR spectra, C NMR calculations, and electronic circular dichroism (ECD) calculations. Heilaohuacids A and B ( and ) contain a 3,4- ring A and unprecedented migration of Me-18 from C-13 to C-17 or C-14 to C-18.

Anti-inflammatory and antioxidant activities of chemical constituents from the flower buds of .

Five new glycosides including mimenghuasu A and B (-), isolinarin (), cyclocitralosides A and B (), along with forty-seven known compounds were isolated from the flower buds of . These structures were elucidated by extensive spectroscopic analysis (UV, IR, 1 D, 2 D NMR, and MS spectra). The anti-inflammatory activities of the isolated compounds were determined by enzyme-linked immunosorbent assay (ELISA) on the expression of TNF- (LPS-activated RAW264.

Heilaohuguosus A-S from the fruits of Kadsura coccinea and their hepatoprotective activity.

Phytochemical investigations on the fresh fruits of Kadsura coccinea (Lem.) A. C.

Identification of potential diagnostic biomarkers of acute pancreatitis by serum metabolomic profiles.

Acute pancreatitis (AP) is defined as an acute inflammation of pancreas that may cause damage to other tissues and organs depending upon the severity of symptoms. The diagnosis of AP is usually made by detection of raised circulating pancreatic enzyme levels, but there are occasional false positive and false negative diagnoses and such tests are often normal in delayed presentations. More accurate biomarkers would help in such situations.