"Multi-in-One" Yolk-Shell Structured Nanoplatform Inducing Pyroptosis and Antitumor Immune Response Through Cascade Reactions.

Pyroptosis, a new mode of regulatory cell death, holds a promising prospect in tumor therapy. The occurrence of pyroptosis can trigger the release of damage-associated molecular patterns (DAMPs) and activate the antitumor immune response. Moreover, enhancing intracellular reactive oxygen species (ROS) generation can effectively induce pyroptosis.

pH-Sensitive Bioprobe for Multichannel Mitochondrial Imaging and Photodynamic Therapy.

Tumor targeting therapy and photodynamic therapy are effective anti-cancer therapies. Their research progress has attracted wide attention and is one of the focuses of anti-cancer drug research and development. The design and synthesis of multifunctional organic phototheranostic agents for superior image-guided diagnosis and phototherapy play an increasingly positive role in cancer diagnosis and treatment.

Reduced state transition barrier of CDK6 from open to closed state induced by Thr177 phosphorylation and its implication in binding modes of inhibitors.

Background: CDK6 is considered as a highly validated anticancer drug target due to its essential role in regulating cell cycle progression at G1 restriction point. Activation of CDK6 requires the phosphorylation of Thr177 on A-loop, but the structural insights of the activation mechanism remain unclear.

Methods: Herein, all-atoms molecular dynamics (MD) simulations were used to study the effects of Thr177 phosphorylation on the dynamic structure of CDK6-Vcyclin complex.

Hydrothermal synthesis for high-quality glutathione-capped Cd Zn Se and Cd Zn Se/ZnS alloyed quantum dots and its application in Hg(II) sensing.

High-quality Cd Zn Se and Cd Zn Se/ZnS core/shell quantum dots (QDs) emitting in the violet-green spectral range have been successfully prepared using hydrothermal methods. The obtained aqueous Cd Zn Se and Cd Zn Se/ZnS QDs exhibit a tunable photoluminescence (PL) emission (from 433.5 nm to 501.

Microcalorimetric studies on the energy release of isolated rat mitochondria under different concentrations of gadolinium (III).

Gadolinium-based compounds are most widely utilized for paramagnetic contrast agents, but, the toxicological mechanism of gadolinium (Gd) had not been fully elucidated since the first report about Gd anomaly. In this work, we analyzed the effect of Gd(3+) on mitochondria in vitro by microcalorimetry. Microcalorimetry can provide detailed kinetic and thermodynamic information from thermogenic curve.

Adhesion of quantum dots-induced membrane damage of Escherichia coli.

The toxicity of CdTe QDs modified with three different ligands, namely mercaptopropionic acid (MPA), N-acetyl-L-cysteine (NAC), and glutathione (GSH), were investigated via microcalorimetric, spectroscopic, and microscopic methods. The three ligand-modified QDs have nearly identical hydrodynamic size. The results of the calorimetric experiments and optical density measurements indicate that the QDs inhibited the growth of Gram-negative Escherichia coli.