Evaluation of a respiratory motion-corrected image reconstruction algorithm in 2-[F]FDG and [Ga]Ga-DOTA-NOC PET/CT: impacts on image quality and tumor quantification.

Background: Respiratory motions may cause artifacts on positron emission tomography (PET) images that degrade image quality and quantification accuracy. This study aimed to evaluate the effect of a respiratory motion-corrected image reconstruction (MCIR) algorithm on image quality and tumor quantification compared with nongated/nonmotion-corrected reconstruction.

Methods: We used a phantom consisting of 5 motion spheres immersed in a chamber driven by a motor.

Small lesion depiction and quantification accuracy of oncological F-FDG PET/CT with small voxel and Bayesian penalized likelihood reconstruction.

Background: To investigate the influence of small voxel Bayesian penalized likelihood (SVB) reconstruction on small lesion detection compared to ordered subset expectation maximization (OSEM) reconstruction using a clinical trials network (CTN) chest phantom and the patients with F-FDG-avid small lung tumors, and determine the optimal penalty factor for the lesion depiction and quantification.

Methods: The CTN phantom was filled with F solution with a sphere-to-background ratio of 3.81:1.

Impact of total variation regularized expectation maximization reconstruction on the image quality of Ga-PSMA PET: a phantom and patient study.

Objectives: To investigate the impact of total variation regularized expectation maximization (TVREM) reconstruction on the image quality of Ga-PSMA-11 PET/CT using phantom and patient data.

Methods: Images of a phantom with small hot sphere inserts and 20 prostate cancer patients were acquired with a digital PET/CT using list-mode and reconstructed with ordered subset expectation maximization (OSEM) and TVREM with seven penalisation factors between 0.01 and 0.

A preliminary study of imaging paclitaxel-induced tumor apoptosis with (99)Tc(m)-His10-Annexin V.

Background: In tumors the process of apoptosis occurs over an interval of time after chemotherapy. It is important to determine the best time for detecting apoptosis by in vivo imaging. In this study, we evaluated the dynamics and feasibility of imaging non-small cell lung cancer (NSCLC) apoptosis induced by paclitaxel treatment using a (99)Tc(m)-labeled Annexin V recombinant with ten consecutive histidines (His10-Annexin V) in a mouse model.

[Technetium-99m labeled synaptotagmin I C2A detection of paclitaxel-induced apoptosis in non-small cell lung cancer].

Unlabelled: Objective To evaluate the efficacy of 99mTc-labeled C2A probe in detection of apoptosis of non-small cell lung cancer (NSCLC) cells after chemotherapy.

Methods: Imaging studies were performed in NSCLC H460-bearing mice. The mice were divided into 2 groups: the paclitaxel-treated group and control group.

[Application of technetium-99m labelled sandostatin Somatostatin receptor imaging in the detection of lung cancer].

Objective: To evaluate the clinical value of (99)Tc(m)-sandostatin receptors imaging ((99)Tc(m)-sandostatin) in detection of lung tumors in comparison with fludeoxyglucose F18 dual head coincidence imaging ((18)F-FDG DHC).

Methods: Fifty-six consecutive patients (40 men, 16 women; mean age: 62 years, range 35 - 80 years) with pulmonary neoplasm were referred for evaluation. All underwent sandostatin scintigraphy using hybrid SPECT/CT.