Publications by authors named "Qing-Lan Lyu"
MicroRNA Profiling of Transgenic Mice with Myocardial Overexpression of Nucleolin.
Chin Med J (Engl)
February 2018
Article Synopsis
- - Nucleolin (NCL) is an essential RNA-binding protein involved in various cellular functions like chromatin stability and ribosome assembly, but its specific actions on microRNA (miRNA) expression are not well understood.
- - The study created transgenic mice that overexpress NCL in the heart to analyze changes in miRNA profiles, revealing 11 miRNAs were upregulated and 4 downregulated compared to wild-type mice, confirmed by further testing.
- - The findings suggest that the protective effects of NCL on heart cells may be linked to the miRNAs identified, indicating a potential regulatory role for NCL in cardiac health.