Background: Conflicting results have been reported about the association between the Ki67 labeling index (Ki67-Li) and clinical outcome in patients with colorectal cancer (CRC).
Patients And Methods: Ki67 expression was assessed by immunohistochemistry (IHC) in 2,233 consecutive CRC cases.
Results: We determined 992 cases to have a low and 1,241 cases to have a high Ki67-Li (representing an approximately 44-56% breakdown in distribution between low versus high patients designated by phenotype).