Publications by authors named "Qing-Hu Mo"
Phloroglucinol derivatives rhotomensones A-G from Rhodomyrtus tomentosa.
Phytochemistry
October 2021
Undescribed phloroglucinol derivatives, rhotomensones A-G, and a known derivative rhodomyrtosone B, were isolated from the leaves of Rhodomyrtus tomentosa. Rhotomensones A-D and G have unreported structural characteristics, in which rhotomensone A substitutes a benzene ring, rhotomensones B-D are bonded with a 2-methylbutanoyl group, and rhotomensone G has two fewer carbons. The structures of these compounds were determined by NMR spectroscopy, circular dichroism (CD) spectroscopy and X-ray crystallography.
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- Coumarins, which are found in various plants, possess several pharmacological properties, including antiviral effects.
- This study isolated a specific coumarin, esculetin, identified through spectroscopy, and tested its anti-hepatitis B virus (HBV) activity in both lab cell lines and infected ducklings.
- Results showed that esculetin significantly reduced HBV antigen expression and DNA levels in vitro, and lowered several viral markers in vivo, indicating its potential as a future antiviral drug.