Publications by authors named "Qing-He Peng"
To guide individualized intensity-modulated radiotherapy (IMRT), we developed and prospectively validated a multiview radiomics risk model for predicting radiation-induced hypothyroidism in patients with nasopharyngeal carcinoma. And simulated radiotherapy plans with same dose-volume-histogram (DVH) but different dose distributions were redesigned to explore the clinical application of the multiview radiomics risk model. The radiomics and dosiomics were built based on selected radiomics and dosiomics features from planning computed tomography and dose distribution, respectively.
View Article and Find Full Text PDFArticle Synopsis
- * A total of 273 patients were treated, with those receiving both immunochemotherapy and radiotherapy showing significantly better progression-free survival (80.6% vs. 65.1%) and overall survival (98.3% vs. 89.5%) compared to those on immunochemotherapy alone.
- * The research highlights that the most benefit is seen in patients with oligometastases, lower levels of EBV DNA, and positive responses to immunochemotherapy, while also noting the presence of some treatment-related side effects.*
Article Synopsis
- Radiotherapy is the main treatment for nasopharyngeal carcinoma, but radiation-induced temporal lobe injury (TLI) can become irreversible if not detected early; this study aimed to create a risk-based follow-up schedule for better early detection of TLI.
- A deep learning model was developed and tested on 6065 patients to stratify risk groups; it significantly outperformed traditional prediction methods and suggested follow-up schedules that could detect TLI 1.9 months earlier than the typical guidelines.
- The results indicated that the model improved planning evaluations by identifying better treatment plans that reduced the risk of TLI, achieving high concordance indexes in the process.
Purpose: We aimed to assess the value of dose distribution-based dosiomics and planning computed tomography-based radiomics to predict radiation-induced temporal lobe injury (TLI) and guide individualized intensity modulated radiation therapy.
Methods And Materials: A total of 5599 nasopharyngeal carcinoma patients were enrolled, including 2503, 1072, 988, and 1036 patients in the training, validation, prospective test, and external test cohorts, respectively. The concordance index (C-index) was used to compare the performance of the radiomics and dosiomics models with that of the quantitative analyses of normal tissue effects in the clinic and Wen's models.
Benefit of [F] FDG PET/CT in the diagnosis and salvage treatment of recurrent nasopharyngeal carcinoma.
Eur J Nucl Med Mol Imaging
February 2023
Article Synopsis
- The study compared the effectiveness of PET/CT, MRI, and ultrasonography in detecting nasopharyngeal carcinoma recurrence and their impact on patient outcomes.
- Results showed that PET/CT was more sensitive than MRI for local recurrence and lymph node diagnosis, and it offered more accurate staging.
- Patients who received staging with both PET/CT and MRI had a significantly higher 3-year overall survival rate compared to those who were staged with MRI alone.
The aims of this study were to investigate the short-term and long-term efficacies and chronic radiotoxicity of concurrent chemoradiotherapy (CCRT) combined with image-guided adaptive brachytherapy (IGABT) in patients with locally advanced cervical cancer (LACC) and identify prognostic factors in this patient population. The clinical data of 204 patients with cervical cancer who completed CCRT and subsequent brachytherapy in our hospital between February 2015 and March 2017 were retrospectively analyzed. Short-term and long-term outcomes, chronic radiotoxicity, and prognostic factors were assessed.
View Article and Find Full Text PDFBackground: We evaluated the prognostic value of serum bilirubin in advanced nasopharyngeal carcinoma (NPC) patients.
Methods: Seven-hundred fifty-nine advanced NPC patients treated with definitive chemoradiotherapy were retrospectively analyzed. Serum indirect bilirubin (IBIL) and direct bilirubin (DBIL) were measured before treatment.
To investigate the ATP-sensitive potassium channel (KATP channel) protein expressions during different periods under hypoxia condition and explore the effect of Qibai Pingfei capsule medicated serum (hereinafter referred to as QBPF) on the correlation between the protein expressions of KATP channel and nitric oxide in rat pulmonary arterial smooth muscle cells(PASMCs). Qibai Pingfei capsules were given to SD rats via continuous gavage for 10 days to obtain QBPF. Primary rats PASMCs were cultured by the direct adherent culture method.
View Article and Find Full Text PDFResearch on frequency of application with modern Chinese herbal medicine.
Chin J Integr Med
January 2011
Objective: To study the relationship between 500 kinds of commonly used Chinese herbal medicine and the classification of their efficacies in Chinese Materia Medica in relation to the common diseases listed in Internal Medicine.
Methods: Database retrieval frequency of the quantitative statistical method was adopted. First, the 8 980 kinds of Chinese herbal medicine recorded in Chinese Materia Medica were used as the original search objects, and 4 493 kinds which were cited in more than five articles were picked out and then rechecked for further title citations.