Publications by authors named "Qing-Feng Xiang"
Application of Transparent Cap-assisted Choledochoscopy in Endoscopic Gallbladder-preserving Surgery.
Surg Laparosc Endosc Percutan Tech
August 2020
Background: The gold standard treatment for cholecystolithiasis is laparoscopic cholecystectomy. However, the complications of cholecystectomy have led to adoption of gallbladder-preserving surgery. The study was to investigate significance of transparent cap-assisted choledochoscopy in gallbladder-preserving surgery.
View Article and Find Full Text PDFActivation of MET promotes resistance to sorafenib in hepatocellular carcinoma cells via the AKT/ERK1/2-EGR1 pathway.
Artif Cells Nanomed Biotechnol
December 2019
Sorafenib is an oral multikinase inhibitor that has become an established therapeutic approach in advanced hepatocellular carcinoma (HCC). However, the benefit of sorafenib in clinical therapy is often affected by drug resistance. Therefore, it is important to explore the mechanisms underlying sorafenib resistance and to develop individualized therapeutic strategies for coping with this problem.
View Article and Find Full Text PDFArticle Synopsis
- Cabozantinib is a multitargeted tyrosine kinase inhibitor currently undergoing phase III trials for hepatocellular carcinoma (HCC), focusing on reversing drug resistance caused by P-glycoprotein (P-gp).
- The study found that cabozantinib increased the effectiveness of P-gp substrate drugs without affecting non-P-gp substrates or altering the expression levels of P-gp itself; instead, it enhanced the activity of P-gp ATPase.
- Ultimately, cabozantinib may aid in overcoming multidrug resistance in HCC and improving chemotherapy outcomes by directly inhibiting P-gp's function.
Currently, available methods for diagnosis of acute pancreatitis (AP) are mainly dependent on serum enzyme analysis and imaging techniques that are too low in sensitivity and specificity to accurately and promptly diagnose AP. The lack of early diagnostic tools highlights the need to search for a highly effective and specific diagnostic method. In this study, we synthesized a conditionally activated, gadolinium-containing, nanoparticle-based MRI nanoprobe as a diagnostic tool for the early identification of AP.
View Article and Find Full Text PDFEffect of BIBF 1120 on reversal of ABCB1-mediated multidrug resistance.
Cell Oncol (Dordr)
February 2011
Background: The overexpression of ATP-binding cassette (ABC) transporters is one of the main causes of multi-drug resistance (MDR) which represents a major obstacle to the success of cancer chemotherapy. In this study, we examined the effect of BIBF 1120, an inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) tyrosine kinases, on the reversal of multidrug resistance in vitro.
Methods: The doxorubicin and rhodamine 123 retention assay was performed by flowcytometry.