Development and application of a nomogram model for predicting the risk of central precocious puberty in obese girls.

Objective: The purpose of this study is to develop and assess a nomogram risk prediction model for central precocious puberty (CPP) in obese girls.

Methods: We selected 154 cases of obese girls and 765 cases of non-obese girls with precocious puberty (PP) who underwent the gonadotropin-releasing hormone stimulation test at the Jiangxi Provincial Children's Hospital. Univariate analysis and multivariate analysis were conducted to identify predictors of progression to CPP in girls with PP.

Tip60-FOXO regulates JNK signaling mediated apoptosis in .

The JNK signaling pathway plays crucial roles in various physiological processes, including cell proliferation, differentiation, migration, apoptosis, and stress response. Dysregulation of this pathway is closely linked to the onset and progression of numerous major diseases, such as developmental defects and tumors. Identifying and characterizing novel components of the JNK signaling pathway to enhance and refine its network hold significant scientific and clinical importance for the prevention and treatment of associated cancers.

Cardiomyocyte peroxisome proliferator-activated receptor α is essential for energy metabolism and extracellular matrix homeostasis during pressure overload-induced cardiac remodeling.

Peroxisome proliferator-activated receptor α (PPARα), a ligand-activated nuclear receptor critical for systemic lipid homeostasis, has been shown closely related to cardiac remodeling. However, the roles of cardiomyocyte PPARα in pressure overload-induced cardiac remodeling remains unclear because of lacking a cardiomyocyte-specific Ppara-deficient (Ppara) mouse model. This study aimed to determine the specific role of cardiomyocyte PPARα in transverse aortic constriction (TAC)-induced cardiac remodeling using an inducible Ppara mouse model.

Shikonin attenuates hyperhomocysteinemia-induced CD4 T cell inflammatory activation and atherosclerosis in ApoE mice by metabolic suppression.

T cell metabolic activation plays a crucial role in inflammation of atherosclerosis. Shikonin (SKN), a natural naphthoquinone with anti-inflammatory activity, has shown to exert cardioprotective effects, but the effect of SKN on atherosclerosis is unclear. In addition, SKN was found to inhibit glycolysis via targeting pyruvate kinase muscle isozyme 2 (PKM2).

One-pot fabrication of durable antibacterial cotton fabric coated with silver nanoparticles via carboxymethyl chitosan as a binder and stabilizer.

In this article, durable antimicrobial cotton fabric was prepared by a one-pot modification process using a colloidal solution of silver nanoparticles (Ag NPs) stabilized by carboxymethyl chitosan (CMC). Due to coordination bonds between the amine groups of CMC and the Ag NPs and the ester bonds present between the carboxyl groups of CMC and the hydroxyl groups of cellulose, the Ag NPs were tightly immobilized onto the cotton fiber surface. As a result, the Ag NPs that were adhered on the cotton fabrics have uniform dispersion and small size, ranging from 10 nm to 80 nm.

Surface modification by carboxymethy chitosan via pad-dry-cure method for binding Ag NPs onto cotton fabric.

To obtain durably antimicrobial cotton fabric, carboxymethyl chitosan (CMC) was covalently linked to cotton fibers via an esterification with the cellulose hydroxyl groups, and the silver nanoparticles (Ag NPs) were adhered to the fiber surface by the coordination bonds with the amino groups of CMC. The finished cotton fabrics have an excellent antibacterial function and outstanding laundering durability. Even after 50 consecutive laundering tests, the modified cotton fabrics still show satisfactory bacterial reduction rates (BR) against both S.

DKK3 overexpression attenuates cardiac hypertrophy and fibrosis in an angiotensin-perfused animal model by regulating the ADAM17/ACE2 and GSK-3β/β-catenin pathways.

Aims: Cardiac pressure and humoral factors induce cardiac hypertrophy and fibrosis, which are characterized by increased stiffness, reduced contractility and altered perfusion. Angiotensin II (AngII) is well known to promote this pathology. Angiotensin-converting enzyme (ACE) 2, which cleaves AngII and forms Ang-(1-7), exerts protective anti-hypertrophy and anti-fibrosis effects.

Antibacterial cotton fabric with enhanced durability prepared using silver nanoparticles and carboxymethyl chitosan.

Carboxymethyl chitosan (CMCTS) and silver nanoparticles (Ag NPs) were successfully linked onto a cotton fabric surface through a simple mist modification process. The CMCTS binder was covalently linked to the cotton fabric via esterification and the Ag NPs were tightly adhered to the fiber surface by coordination bonds with the amine groups of CMCTS. As a result, the coating of Ag NPs on the cotton fabric showed excellent antibacterial properties and laundering durability.

Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode.

Background: Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF.

Method: In this study, we present a "system to system" (S2S) mode.

Rheological effects of blood in a nonplanar distal end-to-side anastomosis.

This study investigates rheological effects of blood on steady flows in a nonplanar distal end-to-side anastomosis. The shear-thinning behavior of blood is depicted by a Carreau-Yasuda model and a modified power-law model. To explore effects of nonplanarity in vessel geometry, a curved bypass graft is considered that connects to the host artery with a 90 deg out-of-plane curvature.

Endothelial progenitor cells in angiogenesis.

Circulating blood contains a subtype of progenitor cells that have the capacity to differentiate into mature endothelial cells in vitro and in vivo. These cells have been termed endothelial progenitor cells (EPCs). The isolation of EPCs by adherence culture or magnetic microbeads has been described.