Publications by authors named "Qing Yun Tong"
Article Synopsis
- * This study combined short- and long-read scRNA-seq to create a detailed transcriptomic atlas of CRC, revealing 394 dysregulated transcript structures and identifying specific genes and isoforms linked to different tumor cell subpopulations with varied prognoses.
- * An algorithm was developed to link novel peptides from these recurrent tumor-specific transcripts with mass spectrometry data, leading to the discovery of recurring neoepitopes that could potentially inform the creation of new cancer vaccines.
Article Synopsis
- Aberrant post-transcriptional regulation, particularly through RNA-binding proteins (RBPs) like LARP1, plays a significant role in cancer development, specifically colorectal cancer (CRC).
- LARP1 is shown to be upregulated in CRC and interacts with the 3'UTR of the proto-oncogene MYC, enhancing its expression and promoting tumor growth.
- This study highlights a feedback loop where MYC also regulates LARP1 expression, creating a cycle that contributes to CRC tumorigenesis.
3'UTR shortening in cancer has been shown to activate oncogenes, partly through the loss of microRNA-mediated repression. This suggests that many reported microRNA-oncogene target interactions may not be present in cancer cells. One of the most well-studied oncogenes is the transcription factor MYC, which is overexpressed in more than half of all cancers.
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