Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity.

Docetaxel is an adjuvant chemotherapy drug widely used to treat multiple solid tumors; however, its toxicity and side effects limit its clinical efficacy. Herein, docetaxel-loaded solid lipid nanoparticles (DSNs) were developed to reduce systemic toxicity of docetaxel while still keeping its anticancer activity. To evaluate its anticancer activity and toxicity, and to understand the molecular mechanisms of DSNs, different cellular, molecular, and whole genome transcription analysis approaches were utilized.

Overexpression of adenylate cyclase-associated protein 1 may predict brain metastasis in non-small cell lung cancer.

This study was designed to establish a biomarker risk model for predicting brain metastasis (BM) in non-small cell lung cancer (NSCLC). The model comprises 120 cases of NSCLC that were treated and followed up for 4 years. The patients were divided into the BM (n=50) and non-BM (other visceral metastasis and those without recurrence) (n=70) groups.

[On connotation of Jin's three-needle technique].

Jin's three-needle technique is named after Professor JIN Rui. The connotation of Jin's three-needle technique is summarized by his followers through long-term teaching and clinical practice. His principle and method of point combination are based on syndrome differentiation of acupuncture.

[Correlation between pelvic indices, pelvic spatial orientation and lumbar vertebrate instability].

Objective: To explore the correlation between the stability of lumbar vertebrate and pelvic indices of pelvic incidence (PI), lumber lordosis (LL), pelvic tilt (PT) and sacrum slope (SS).

Methods: The preoperative imaging data were analyzed retrospectively for 78 patients with lumbar disc protrusion. The values of PI, PT, SS and LL were measured and compared between lumbar vertebrate stability and lumbar vertebrate instability groups.

The association between C-159T polymorphism in CD14 gene and susceptibility to tuberculosis: a meta-analysis.

The association between CD14 gene C-159T polymorphism and tuberculosis (TB) susceptibility remains inconclusive. To derive a more precise estimation of the correlation, we performed a meta-analysis summarize the possible at a systematic manner. PubMed, HighWire and ScienceDirect databases covering all papers (up to November 2012) were searched.

The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity.

Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level which allows the tumor cell apoptosis to occur in a Au dose dependent manner.

Diversity and recombination of human parechovirus in children with acute gastroenteritis in Guangzhou, China.

Human parechovirus (HPeV), a member of Picornaviridae family, is a widespread pathogen causing a wide spectrum of diseases. Like other picornaviruses, HPeV genome recombination has been detected. A total of 322 fecal samples were collected from children outpatients in Guangzhou, China, including 42 (13.

Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles.

Although chemotherapeutic drugs are widely applied for clinic tumor treatment, severe toxicity restricts their therapeutic efficacy. In this study, we reported a new form of selenium, selenium nanoparticles (Nano Se) which have significant lower toxicity and acceptable bioavailability. We investigated Nano Se as chemotherapy preventive agent to protect against toxicities of anticancer drug irinotecan and synergistically enhance the anti-tumor treatment effect in vitro and in vivo.

Intercalated graphitic carbon nitride: a fascinating two-dimensional nanomaterial for an ultra-sensitive humidity nanosensor.

We develop a novel humidity nanosensor based on intercalated graphitic carbon nitride (g-C(3)N(4)) nanosheets fabricated by a facile thermal polymerization of common urea in the presence of LiCl as the intercalated guest under air and ambient pressure. The response and recovery times of an optimal nanosensor can reach ∼ 0.9 s and ∼ 1.

Schedule-dependent synergistic interaction between docetaxel and gefitinib in NSCLC cell lines regardless of the mutation status of EGFR and KRAS and its molecular mechanisms.

Background: Tyrosine-kinase inhibitors (TKIs) and chemotherapy had different pharmacological mechanisms and therefore combined administration of TKIs and chemotherapy agents may have synergy. Our research aimed at exploring the cytotoxic interactions between gefitinib and docetaxel with different concentrations for non-small-cell lung cancer cell lines, and furthermore, the mechanisms underlying the cytotoxic synergism.

Methods: NCI-H1650 [epidermal growth factor receptor (EGFR) mutation and KRAS wild-type], NCI-H292 (EGFR wild-type and KRAS wild-type) and A549 (EGFR wild-type and KRAS mutation) cell lines were treated with docetaxel and/or gefitinib.

Facile fabrication and enhanced photosensitized degradation performance of the g-C3N4-Bi2O2CO3 composite.

Flower-like Bi2O2CO3 and g-C3N4-Bi2O2CO3 microspheres with a high adsorption ability were synthesized using a facile method, and their dye-induced photosensitized degradation activity under visible light irradiation was evaluated. The as-synthesized samples were characterized by XRD, FT-IR, FESEM, TEM (HRTEM), UV-vis DRS and nitrogen adsorption-desorption techniques. It was found that the activity of Bi2O2CO3 was significantly enhanced due to the generation of g-C3N4-Bi2O2CO3 heterostructures.

Geometric distortion in diffusion-weighted MR imaging of the prostate-contributing factors and strategies for improvement.

Rationale And Objectives: Image distortion on diffusion-weighted imaging (DWI) of the prostate in 3T endorectal magnetic resonance imaging (MRI) examinations is common. The aim of this study was to determine the degree of distortion on DWI using a state-of-the-art clinical protocol and to explore the main contributors to geometric distortion.

Materials And Methods: Forty consecutive patients underwent 3T MRI of the prostate with an endorectal coil filled with air (n = 20) or barium sulfate (n = 20).

[Comparison of anxiety and depression state among patients with different type of vestibular peripheral vertigo].

Objective: To investigate and analyze the status of anxiety and depression among patients with four types of peripheral vertigo.

Method: The clinical data of patients with one of the four types of peripheral vertigo, namely benign paroxysmal positional vertigo (BPPV), vestibular migraine (VM), Menière's disease (MD), and vestibular neuritis (VN), were collected. Thorough otological and neuro-otological examinations were performed on these patients, and their status of anxiety and depression were assessed using self-rating anxiety scale (SAS) and self-rating depression scale (SDS).

Preparation of a nano emodin transfersome and study on its anti-obesity mechanism in adipose tissue of diet-induced obese rats.

Objective: To describe the preparation of nano emodin transfersome (NET) and investigate its effect on mRNA expression of adipose triglyceride lipase (ATGL) and G0/G1 switch gene 2 (G0S2) in adipose tissue of diet-induced obese rats.

Methods: NET was prepared by film-ultrasonic dispersion method. The effects of emodin components at different ratios on encapsulation efficiency were investigated.

Active hydrogen species on TiO2 for photocatalytic H2 production.

Photocatalytic H2 production over TiO2 has attracted tremendous attention and achieved great progress, but the active hydrogen species is still unknown. Employing a rutile TiO2(110) surface as a model catalyst we report here for the first time the direct observation of photocatalytic H2 production under ultrahigh vacuum conditions during UV-light irradiation at 115 K and the identification of negatively-charged hydride-type H-Ti species as the corresponding photoactive surface species by means of thermal desorption spectroscopy, photon-stimulated desorption spectroscopy, X-ray photoelectron spectroscopy and DFT calculations. The formation and stability of H-Ti species are closely related to available surplus electrons on the rutile TiO2(110) surface that can be created by the formation of surface BBO vacancies or by the formation of surface hydroxyls via the adsorption of atomic H or molecular H2 on O sites.

Silencing of DLGAP5 by siRNA significantly inhibits the proliferation and invasion of hepatocellular carcinoma cells.

Background: The dysregulation of oncogenes and tumor suppressor genes plays an important role in many cancers, including hepatocellular carcinoma (HCC), which is one of the most common cancers in the world. In a previous microarray experiment, we found that DLGAP5 is overexpressed in HCCs. However, whether the up-regulation of DLGAP5 contributes to hepatocarcinogenesis remains unclear.

Compression of left common iliac vein is independently associated with left-sided deep vein thrombosis.

Objective: Left-sided lower extremity deep vein thrombosis (DVT) is more common than right-sided DVT. This difference was found to be caused by the compression of the left iliac common vein (LCIV). To evaluate and compare LCIV compression in unilateral DVT patients and the normal population and investigate the association of LCIV compression with the risk of left-sided DVT.

Magnetically separable Fe3O4@SiO2@TiO2-Ag microspheres with well-designed nanostructure and enhanced photocatalytic activity.

Major efforts in modern material chemistry are devoted to the design and fabrication of nanostructured systems with tunable physical-chemical properties for advanced catalytic applications. Here, a novel Fe3O4@SiO2@TiO2-Ag nanocomposite has been synthesized and characterized by a series of techniques including SEM, TEM, XRD, XPS as well as magnetization measurement and subsequently tested for the photocatalytic activities. The well-designed nanocomposite exhibits significantly superior activity to that of the commercial Degussa P25 thanks to the suppression of electron-hole pairs from recombination by Ag nanoparticles, and can be easily recycled by applying an external magnetic field while maintaining the catalytic activity without significant decrease even after running 10 times.

Room-temperature synthesis of flower-like BiOX (X═Cl, Br, I) hierarchical structures and their visible-light photocatalytic activity.

A simple method for facile synthesis of three-dimensional (3D) bismuth oxyhalide (BiOX, X═Cl, Br, I) hierarchical structures at room temperature has been developed. Under the influence of L-lysine surfactant, the bismuth and halogen (Cl, Br, I) sources hydrolyze and self-assemble into flower-like hierarchical architectures within 10 min. The resulted materials were characterized by XRD, FESEM, TEM, UV-vis DRS, and N2 adsorption-desorption techniques.

[Treatment of autism children: observation on efficacy of behavior training with retention of needles on head].

Objective: To observe the effect difference of behavior training with head needling retention and behavior training after acupuncture for autism children.

Methods: Sixty qualified autism children were divided randomly into simultaneous head needling retention and behavior training group (trial group) and behavior training after acupuncture treatment group (control group) with 30 case in each group. Retention needles on the head with simultaneous behavior training was applied for the trial group.

Tripterygium wilfordii Hook F (a traditional Chinese medicine) for primary nephrotic syndrome.

Background: Tripterygium wilfordii Hook F (TwHF), a traditional Chinese herbal medicine used as an immunosuppressive agent, has been prescribed in China for patients with primary nephrotic syndrome (NS) for more than two decades. Although patients with primary NS in China have benefited from TwHF treatment, its properties have not yet been fully understood.

Objectives: To assess the benefits and harms of TwHF for patients with primary NS.