The interdependence of mid-trimester blood pressure and glucose levels in shaping fetal growth and neonatal outcomes: implications for risk-benefit assessment and co-management.

Background: Maternal hypertension and hyperglycemia are closely related but have distinct impacts on fetal growth and are managed independently. How the interdependence of blood pressure (BP) and glucose levels quantitatively influences risk patterns for abnormal fetal growth and neonatal complications remains unexplored.

Methods: Maternal BP and fasting plasma glucose (FPG) levels were measured between 20 and 28 weeks of gestation in a cohort including 56,881 singleton pregnancies.

Unravelling the key flavor components of beer based on a new online recombination olfactometry of mixed targeted compounds.

Molecular sensory science provides a powerful methodology to uncover the relationships between chemical components and sensory attributes, identify key aroma compounds and develop food flavor profiles. However, this approach is labor-intensive and resource-demanding due to the need for off-line aroma extraction, dilution and recombination tests using standard references. This complexity causes unsatisfactory recombination results, particularly when identifying certain compounds is challenging.

Low-Level Viremia Impairs Efficacy of Immune Checkpoint Inhibitors in Unresectable Hepatocellular Carcinoma.

Background And Aims: The impact of low-level viremia(LLV) on the efficacy of immune checkpoint inhibitors (ICIs) in unresectable hepatocellular carcinoma(uHCC) patients remains unclear. This study aims to investigate the effect of LLV on the outcomes of ICIs-based therapy in patients with uHCC.

Methods: In this multicenter retrospective study, we included patients with uHCC who received ICIs-based therapy at four centres between January 2019 and December 2022.

Genome-Wide Association Study and Genomic Prediction of Soybean Mosaic Virus Resistance.

Soybean mosaic virus (SMV), a pathogen responsible for inducing leaf mosaic or necrosis symptoms, significantly compromises soybean seed yield and quality. According to the classification system in the United States, SMV is categorized into seven distinct strains (G1 to G7). In this study, we performed a genome-wide association study (GWAS) in GAPIT3 using four analytical models (MLM, MLMM, FarmCPU, and BLINK) on 218 soybean accessions.

Characterization of Klebsiella pneumoniae Carbapenemase (KPC)-14, a KPC Variant Conferring Resistance to Ceftazidime-Avibactam in the Extensively Drug-resistant ST463 Pseudomonas aeruginosa Clinical Isolate.

Objectives: We studied two Klebsiella pneumoniae carbapenemase (KPC)-14 variants from clinical Pseudomonas aeruginosa isolates (C137 and C159) to better understand the genomic diversity, mechanisms, and genes that confer antibiotic resistance and pathogenicity.

Methods: Genomic DNA from C137/159 was subjected to Illumina and Oxford Nanopore sequencing. Horizontal transmission of the plasmid was evaluated using cloning experiments.

Impacts of Naphthenic Acids (NAs) Exposure on Soil Bacterial Community and Antibiotic Resistance Genes (ARGs) Dissemination.

Naphthenic acids (NAs) are indigenous and complex components in petroleum. In the context of increasing global energy demand, the increasing extraction of fossil resources leads to increased environmental release of NAs, resulting in various environmental risks. However, the impact of NAs exposure on soil microorganisms remains still unclear.

Evaluation of elite table tennis players' comprehensive technical and tactical performance.

Background: Game performance analysis has been playing a significant role in sports events which has reached an international consensus. In the field of technical and tactical analysis of table tennis, many studies conducted the segmented evaluation of players based on the phased-theory. The present study proposed the concepts of "competitive technical and tactical performance" of elite table tennis players.

Catalytic Mechanism of Gut Benzyl Ether Reductase for Efficient Bioconversion of Furofuran Lignans into Enterolignan Precursors.

Enterolignan is a vital anticancer compound, and benzyl ether reductase (BER) plays a key role in its biosynthesis by facilitating lignan biotransformation. Using virtual alanine scanning and site-directed mutagenesis, we identified critical residues influencing BER activity in DSM 2243. Mutations Y214A, K383A, and K395A led to a near-complete loss of enzymatic activity, highlighting their essential roles.

Clinical Outcomes and Prognostic Factors in Bullous Pemphigoid Patients: A 15-Year Review in China.

Background: There are limited data on clinical outcomes and prognosis factors for bullous pemphigoid (BP) at long-term follow-up.

Objective: We aimed to investigate the clinical outcomes and prognostic factors in BP patients.

Methods: This retrospective study was performed between January 1, 2009 and December 31, 2023 in Shandong Province, China.

Early β-Blocker Use and Clinical Outcomes in Acute Myocardial Injury: A Retrospective Cohort Study.

Background: Acute myocardial injury is defined by elevated cardiac troponin (cTn) levels with a rising and/or falling pattern, and is associated with increased mortality risk compared to patients without myocardial injury. The role of β-blockers in patients with acute myocardial injury remains unclear.

Methods: This multicenter, retrospective cohort study used data from the Tianjin Health and Medical Data Platform to assess the impact of early β-blocker use on 1-year all-cause mortality and major adverse cardiovascular events (MACE) in acute myocardial injury patients, employing a new user and target trial emulation design.

The carcinogenic metabolite acetaldehyde impairs cGAS activity to negatively regulate antiviral and antitumor immunity.

The cGAS-MITA/STING pathway plays critical roles in both host defense against DNA virus and intrinsic antitumor immunity by sensing viral genomic DNA or dis-located mitochondrial/cellular DNA. Whether carcinogenic metabolites can target the cGAS-MITA axis to promote tumorigenesis is unknown. In this study, we identified acetaldehyde, a carcinogenic metabolite, as a suppressor of the cGAS-MITA pathway.

Discovery of multi-chitinase inhibitors cinnamyl thiazolidinone compounds as candidates for insect growth regulators via ligand-based optimization strategies.

Chitinases are recognized as potential targets to develop novel insecticides to control lepidopteran pests. However, the design and development of effective multi-chitinase inhibitors remains a huge challenge. Based on the backgrounds, in this study, we designed and synthesized a series of cinnamyl-thiazolidinedione compounds as potential inhibitors against OfChtI, OfChtII and OfChi-h, for the first time, by integrating strategies including fragment replacement, 3D QSAR-guided design, and bioelectronic isosteric replacement.

Early warning method for charging thermal runaway of electric vehicle lithium-ion battery based on charging network.

New energy vehicles are becoming a new trend in global transportation development due to the renewable and environmentally friendly nature of the fuel they consume. At the same time, the charging safety of electric vehicle (EV) lithium-ion battery limits the development of the industry. This paper obtains charging data through the EV charging network, takes the lithium-ion battery charging temperature as the observation value, and proposes an early warning method for EV lithium-ion battery based on the charging network according to the nonlinear relationship between the temperature and the charging voltage, current, and battery status.

Multi-omics insights into the molecular signature and prognosis of hypopharyngeal squamous cell carcinoma.

Approximately two-thirds of hypopharyngeal squamous cell carcinoma (HPSCC) cases are diagnosed at advanced stages, with the worst prognosis among head and neck squamous cell carcinomas (HNSCCs). Identifying biomarkers for high-risk patients requiring aggressive treatment is crucial. We present mutational, transcriptomic, and proteomic studies of 103 Chinese HPSCC patients and observe a higher prevalence and poorer prognosis in males.

Alzheimer's disease (AD) in multiple sclerosis (MS): A systematic review of published cases, mechanistic links between AD and MS, and possible clinical evaluation of AD in MS.

: Alzheimer's disease (AD) and multiple sclerosis (MS) are two neurological disorders that can pose enormous burden to a person's quality of life. Due to new therapeutic advancements that significantly extend the lifespan, there may be an increased prevalence of AD in elderly MS patients. Building on a previous review on MS-AD coexistence, this review not only aimed to broaden the pool of literature searched, but also investigated possible mechanistic links between clinical markers for MS and AD.

A portable chip-based Overhauser DNP platform for biomedical liquid sample analysis.

Low-field nuclear magnetic resonance (NMR) instruments are an indispensable tool in industrial research and quality control. However, the intrinsically low spin polarization at low magnetic fields severely limits their detection sensitivity and measurement throughput, preventing their widespread use in biomedical analysis. Overhauser dynamic nuclear polarization (ODNP) effectively addresses this problem by transferring the spin polarization from free electrons to protons, significantly enhancing sensitivity.

Isolating Astrocyte-Derived Extracellular Vesicles From Urine.

Introduction: Brain-derived extracellular vesicles (BDEVs) can cross the blood-brain barrier and enter the periphery. Therefore, quantifying and analyzing peripherally circulating BDEVs offer a promising approach to directly obtain a window into central nervous system (CNS) pathobiology in vivo. Rapidly evolving CNS diseases require high-frequency sampling, but daily venipuncture of human subjects is highly invasive and usually unfeasible.

Ginsenoside Reshapes Intestinal Microecology to Alleviate Microgravity Stress.

Background: During medium- to long-duration spaceflights, real-time microgravity can increase the health risks of astronauts. In particular, the disruption of intestinal homeostasis is closely related to other health problems, and it is necessary to monitor related treatment strategies. Ginseng is a well-known Chinese herbal medicine often used to maintain health.

Interplay of gut microbiota in Kawasaki disease: role of gut microbiota and potential treatment strategies.

Kawasaki disease (KD) is an acute systemic immune vasculitis with predominant involvement of the medium and small arteries. It mostly affects pediatric patients, representing the most common form of pediatric vasculitis in children less than 5 years old. Numerous diseases, especially those related to the immune system, have established links with the intestinal flora.

Impact of Different Temperatures on Activity of the Pest Motschulsky (Coleoptera: Chrysomelidae).

(Motschulsky) (Coleoptera: Chrysomelidae) is widely distributed in China and is polyphorous, being a major pest to cash crops, such as corn, cotton, and millet. Given the increasing severity of the greenhouse effect in recent years, we aimed to investigate the adaptability of adults to varying temperatures. In this study, we assessed the survival, longevity, fecundity, feeding capacity, and antioxidant capacity of leaf beetle adults under laboratory conditions at 25-34 °C.

Advances in Ceramic-Carbonate Dual-Phase Membrane Reactors for Direct CO Separation and Utilization.

Excessive (carbon dioxide) CO emissions are a primary factor contributing to climate change. As one of the crucial technologies for alleviating CO emissions, carbon capture and utilization (CCU) technology has attracted considerable global attention. Technologies for capturing CO in extreme circumstances are indispensable for regulating CO levels in industrial processes.

Efficacy of natural killer T and gammadelta T cells in mesothelin-targeted immunotherapy of pancreatic cancer.

Current pancreatic cancer immunotherapy focused on alphabeta (αβ) T cells, either through CD3-engaged bispecific antibodies or CAR-T. Despite their promise, dose-limited toxicity (DLT) remains a challenge in clinical practice. In light of these concerns, there is a growing interest in exploring alternative T cell types, natural killer T (NKT) cells and gammadelta (γδ) T cells, that possess the capacity to lyse tumors while potentially offering a safer therapeutic profile with fewer side effects.

Scenario construction and evolutionary analysis of nonconventional public health emergencies based on Bayesian networks.

Objectives: The objective was to aggregate the various scenarios that occur during nonconventional public health emergencies (NCPHEs) and analyze the evolutionary patterns of NCPHEs to better avoid risks and reduce social impacts. The aim was to enhance strategies for handling NCPHEs.

Study Design: News reports were crawled to obtain the scenario elements of NCPHEs and categorized into the spreading stage or derivation stage.

Combined heavy metals (As and Pb) affects antioxidant status and lipid metabolism in zebrafish (Danio rerio).

The potential risk of coexistence of mixed heavy metals in the aquatic environment has increased with the development of technology. Lead (Pb) and arsenic (As) are among the most widely applied heavy metals, whose single toxicity has been extensively investigated, but their combined toxicity has been reported relatively rarely. In this study, different concentrations of Pb (40 μg/L, 4 mg/L), As (32 μg/L, 3.

A comprehensive investigation of the relationship between propulsion speed and water influx in coal mine TBM inclined shaft projects.

To explore the influence of water inflow on the safe and efficient tunneling construction of TBM in water-rich Luohe Formation sandstone. Based on the tunneling data at the main inclined shaft TBM construction site of Kekegai Coal Mine, a relationship model between tunneling speed and water inflow is established by using statistical analysis and machine learning theory; XRD and SEM tests on the microstructural components of Luohe Formation sandstone are carried out to analyze the mechanism of water inflow in argillaceous cemented sandstone affecting the tunneling speed of TBM. The Libsvm support vector machine (SVR) model is more effective than multiple regression and random forest (RF) models in evaluating nonlinear problems.