A Novel ZnCys Transcription Factor, TopC, Positively Regulates Trichodin A and Asperpyridone A Biosynthesis in .

Asperpyridone A represents an unusual class of pyridone alkaloids with demonstrated potential for hypoglycemic activity, primarily by promoting glucose consumption in HepG2 cells. Trichodin A, initially isolated from the marine fungus Trichoderma sp. strain MF106, exhibits notable antibiotic activities against .

Development of a New Heteropolyoxotantalate Cluster for Multidimensional Polyoxotantalate Materials.

A unique heteropolyoxotantalate (hetero-POTa) cluster [POTaO] (PTa) was first developed using pyrophosphate as a key to open the ultrastable skeleton of the classical Lindqvist-type [TaO] precursor. The PTa cluster can serve as a general and flexible secondary building unit to create a family of brand-new multidimensional POTa architectures. This work not only promotes the limited structural diversity of hetero-POTa but also provides a practical strategy for new extended POTa architectures.

Oxalate-assisted assembly of two polyoxotantalate supramolecular frameworks with proton conduction properties.

An oxalate-assisted strategy was first developed for creating new polyoxotantalates (POTas). With this strategy, two brand-new POTa supramolecular frameworks based on uncommon dimeric POTa secondary building units (SBUs) were constructed and characterized. Interestingly, the oxalate ligand can not only serve as a coordination ligand to form unique POTa SBUs but also act as a key hydrogen bond acceptor to construct supramolecular architectures.

3d-4f Heterometallic cluster incorporated polyoxoniobates with magnetic properties.

A series of 3d-4f heterometallic cluster incorporated polyoxoniobates (PONbs) with different magnetic properties were first made and characterized. This work not only provides a promising strategy to make new heterometallic cluster incorporated PONbs but also demonstrates an ideal model to probe how transition-metal ions influence the magnetic property of PONbs.

Atomically Dispersed Co to an End-Adsorbing Molecule for Excellent Biomimetically and Prime Sensitively Detecting O Released from Living Cells.

Single-atom catalysis efficiently exposes the catalytic sites to reactant molecules while rendering opportunity to investigate the catalysis mechanisms at atomic levels for scientific insights. Here, for the first time, atomically dispersed Co atoms are synthesized as biomimetic "enzymes" to monitor superoxide anions (O), delivering ultraordinary high sensitivity (710.03 μA·μM·cm), low detection limit (1.

High-dimensional Polyoxoniobates Constructed from Lanthanide-incorporated High-nuclear {[Ln(H O) ] [Nb O (H O) ] } Secondary Building Units.

In this work, two rare high-dimensional polyoxoniobates with formulas of H [Cu(en)(H O) ][Cu(en) ] [Dy(H O) ] [Nb -O (H O) ]  ⋅ 36H O (1) and H K[Cu(en) (H O)] [Cu(en) ] -[Eu(H O) ] [Nb O (H O) ]  ⋅ 2en ⋅ 45H O (2) have been obtained under hydrothermal conditions. These extended materials are constructed from lanthanide-incorporated triangular-prism-like polyoxoniobate secondary building units (SBUs) {[Ln(H O) ] [Nb O (H O) ] } (Ln=Dy, Eu). 1 and 2 represent the first examples of high-dimensional polyoxometalate materials based on such lanthanide-incorporated triangular-prism-like polyoxoniobate SBUs.

TRPM7 overexpression enhances the cancer stem cell-like and metastatic phenotypes of lung cancer through modulation of the Hsp90α/uPA/MMP2 signaling pathway.

Background: Waixenicin A, a bioactive extract of soft coral Sarcothelia edmondsoni, has been shown to be anti-neoplastic. However, its mechanisms of action remain unclear. Cancer stem cells (CSCs) and associated stemness factors are implicated in lung cancer.

Composite cluster-organic frameworks based on polyoxometalates and copper/cobalt-oxygen clusters.

Two rare mixed-cluster-organic frameworks (CHNH)[Cu-(μ-O)(L)][MnMoO(L)]·4NMF·5HO (1) and [(CH)NH][Co-(μ-O)(L)]-[MnMoO(L)]·5DMF (2) (L = 2-(hydroxymethyl)-2-(pyridin-4-yl)-1,3-propanediol; L = 4-(2-(4-pyridyl)ethenyl) benzoic acid; NMF = N-methylformamide; DMF = N,N-dimethylformamide) have been obtained, exhibiting the first two porous materials simultaneously integrating polyoxometalates and transition-metal-oxygen clusters as secondary building units (SBUs).