Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.

Diabetic kidney disease (DKD), a leading cause of end-stage renal disease (ESRD), poses a serious threat to global health. Aseptic inflammation and pyroptosis of podocytes are crucial factors contributing to the pathogenesis and progression of DKD. Sodium-glucose cotransporter 2 inhibitors (SGLT2i), a novel class of antidiabetic agents widely used in clinical settings, may exert a protective effect on podocyte injury, although the underlying mechanisms remain poorly understood.

Circulating cyclophilin A levels elevate in animal models and can predict mortality in patients with acute pancreatitis.

Background/objectives: Cyclophilin A (CypA) is released into the blood following cellular injury and correlates with acute pancreatitis (AP) severity, however, investigations into circulating CypA in experimental AP and hypertriglyceridaemia-associated AP (HTG-AP) prevalent cohorts are lacking.

Methods: C57Bl/6 mice received 4, 8, and 12 caerulein injections to induce escalating severity of AP models (CER-AP). Mice were sacrificed 1 h after the last injection of caerulein to assess severity of CER-AP through biochemical and histopathological analyses, and serum CypA levels were also measured.

Resveratrol in animal models of pancreatitis and pancreatic cancer: A systematic review with machine learning.

Background: Resveratrol (RES), a common type of plant polyphenols, has demonstrated promising therapeutic efficacy and safety in animal models of pancreatitis and pancreatic cancer. However, a comprehensive analysis of these data is currently unavailable. This study aimed to systematically review the preclinical evidence regarding RES's effects on animal models of pancreatitis and pancreatic cancer via meta-analyses and optimised machine learning techniques.

[Clinical features and surgical treatment strategies of hip arthroplasty for unhealed old femoral intertrochanteric fractures].

Objective: To explore the surgical method and clinical efficacy of hip arthroplasty in the treatment of old non-union femoral intertrochanteric fractures.

Methods: Fifteen unoperated patients suffering from old non-union femoral intertrochanteric fractures from Feburary 2013 to Feburary 2023 were treated with hip arthroplasty including 9 males and 6 females, aged 71 to 82 years old. Eleven cases detected deep venous thrombosis(DVT), 9 cases received lower vena cava filter implantation.

Slice2Mesh: 3D Surface Reconstruction from Sparse Slices of Images for the Left Ventricle.

Cine MRI is a widely used technique to evaluate left ventricular function and motion, as it captures temporal information. However, due to the limited spatial resolution, cine MRI only provides a few sparse scans at regular positions and orientations, which poses challenges for reconstructing dense 3D cardiac structures, which is essential for better understanding the cardiac structure and motion in a dynamic 3D manner. In this study, we propose a novel learning-based 3D cardiac surface reconstruction method, Slice2Mesh, which directly predicts accurate and high-fidelity 3D meshes from sparse slices of cine MRI images under partial supervision of sparse contour points.

Discovery of Novel Pyrazole/Thiazole Derivatives Containing Cyano/Thiocyanato Groups as Fungicide Candidates.

The introduction of groups with high drug activity is an effective strategy for discovering novel succinate dehydrogenase inhibitor (SDHI) fungicides, providing insights for the future design of SDHI fungicides with higher efficacy and resistance. In this study, we designed and synthesized a series of novel pyrazole/thiazole derivatives containing cyano/thiocyanato groups and evaluated them for antifungal activity. Some of the designed compounds exhibited promising antifungal activities against tested fungi, among them, compounds and displayed excellent activity against with EC values of 1.

Pentraxin3 exacerbates acute pancreatitis injury by inhibiting oxidative phosphorylation pathway.

Local pancreatic necrosis and systemic inflammatory response caused by acute pancreatitis (AP) are closely related to the disease prognosis and severity. This study aimed to explore whether pentraxin 3 (PTX3) regulates AP pancreatic necrosis and reveals the underlying mechanism. By using AP time gradient transcriptomics, proteomics and liquid phase chip analysis, we found a close association between PTX3 and AP.

Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalk.

Background: Stem cell-derived secreted factors could protect neurons in neurodegenerative disease or after injury. The exact neuroprotective components in the secretome remain challenging to discover. Here we developed a cell-to-cell interaction model to identify a retinal ganglion cell (RGC)-protective factor derived from induced pluripotent stem cells (iPSCs).

Background-Free Mid-Infrared Photothermal Microscopy via Single-Shot Measurement of Thermal Decay.

Mid-infrared photothermal (MIP) microscopy is an emerging tool for biological imaging, offering high sensitivity, subcellular resolution, and rapid image acquisition. However, the MIP signal of low concentration molecules in biological systems is often hindered or masked by background absorption, largely contributed by water, resulting from the H-O-H scissors-bending band in the fingerprint window or the bend-libration combination band in the cell-silent window. To preserve all desired signals while suppressing the background, we report a single-shot time-resolved MIP measurement that allows differentiation between the background and analyte signal based on their distinct photothermal dynamics.

Recovery trajectories after a serious injury or illness: a longitudinal evaluation of health-related quality of life in an Australian cohort.

Purpose: Serious injuries or illnesses impose a significant burden on the affected individuals. This study examined the long-term recovery of health-related quality of life (HRQoL) after a serious injury or illness and quantified the economic costs attributable to the quality-adjusted life-years (QALYs) lost to serious injury or illness.

Methods: Data were sourced from the Household, Income and Labour Dynamics in Australia (HILDA) database.

Histones are critical toxic factors in gut lymph of severe acute pancreatitis: Neutralization by baicalin and baicalein for protection.

Background: Whether circulating histones in gut lymph contribute to organ failure and impact of chaiqin chengqi decoction (CQCQD) on histones in severe acute pancreatitis (SAP) remain elusive.

Purpose: To verify the role of histones in gut lymph of SAP and evaluate the effect of the CQCQD on them.

Methods: Sodium taurocholate was retrogradely infused into pancreatobiliary duct to induce SAP in rodents.

Improving our understanding of the longitudinal relationship between health-related quality of life and multimorbidity: The role of personality traits.

It is well known that multimorbidity negatively impacts health-related quality of life (HRQoL). However, how psychosocial factors moderate this relationship remains unclear. The present study investigated the moderating effects of personality traits on the relationship between multimorbidity and HRQoL.

Evaluation of the effects on the tensile properties of medical gloves after repeated disinfection.

This study was aimed to explore the effects of the disinfectants commonly used in the hospitals on the tensile properties of the medical gloves with the different materials. Three types of medical gloves, composed of latex, nitrile, and polyvinyl chloride (PVC), were exposed to common chemical disinfectants to analyze the effects on the tensile properties. Ethanol-based hand rub(EBHR) and chlorine antiseptic were selected for testing.

Multi-omics profiles reveal immune microenvironment alterations associated with PD-L1 checkpoint in acute pancreatitis in the early phase.

Background: Acute pancreatitis (AP) initiates as primarily sterile local inflammation that triggers pro-inflammatory response, which is subsequently counterbalanced by an anti-inflammatory response. Immune checkpoints, such as PD-1/PD-L1, play a pivotal role in modulating these responses to prevent excessive immune activation and associated inflammatory damage. This study aimed to investigate the underlying mechanisms of these processes in both murine and human AP.

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU-EMRE Assembly.

The mitochondrial calcium uniporter (MCU) complex mediates Ca entry into mitochondria, which plays a crucial role in regulating cellular energy metabolism and apoptosis. Dysregulation of MCU is implicated in various diseases, such as neurodegenerative disorders, cardiac diseases, and cancer. Despite its importance, developing specific and clinically viable MCU inhibitors is challenging.

The characterization of Herbaspirillum huttiense isolated from a uremic patient: virulence and antimicrobial efficacy in the Galleria mellonella model.

Herbaspirillum species are typically isolated from plants and are known for their role in crop nitrogen fixation. Recently, they have been found to colonize humans and cause infections. This study aimed to identify and characterize two Herbaspirillum huttiense strains (CLJ01 and CLJ02) isolated from the blood of a uremic patient, with a focus on evaluating their pathogenicity and antibiotic efficacy.

An integrated zebrafish model and network pharmacology to investigate the mechanism of Chrysanthemum for treating metabolic dysfunction-associated fatty liver disease.

Chrysanthemum (Chrysanthemum morifolium Ramat) is a food, which serves both as a medicinal and culinary resource in China; however, its active ingredients and mechanisms underlying its hepatoprotective effects remain elusive. This study aimed to investigate the protective effect of water extract from chrysanthemum flowers (WEFC) against metabolic dysfunction-associated fatty liver induced by thioacetamide (TAA) in zebrafish and its underlying mechanisms. The protective effect of WEFC against TAA-induced liver injury was investigated using the liver-specific transgenic zebrafish line, Tg(fabp10a:DsRed).

Traditional Chinese medicine Chaiqinchengqi decoction for patients with acute pancreatitis: A randomized clinical trial.

Background: Chaiqinchengqi decoction, a traditional Chinese medicine, has shown promising effects in in vitro, animal and preliminary small human studies for acute pancreatitis, but evidence of clinical practice is limited.

Purpose: To investigate whether Chaiqinchengqi decoction could improve clinical outcomes in patients with acute pancreatitis.

Study Design: Prospective, pragmatic, randomized controlled trial.

Unveiling the Emerging Role of Xanthine Oxidase in Acute Pancreatitis: Beyond Reactive Oxygen Species.

Acute pancreatitis (AP) is a potentially fatal acute digestive disease that is widespread globally. Although significant progress has been made in the previous decade, the study of mechanisms and therapeutic strategies is still far from being completed. Xanthine oxidase (XO) is an enzyme that catalyzes hypoxanthine and xanthine to produce urate and is accompanied by the generation of reactive oxygen species (ROS) in purine catabolism.

Agingassociated challenges to persons living with HIV/AIDS in Vietnam: integrated perspectives from multiple stakeholders.

This study examined the aging-associated health and care needs among the HIV population in Vietnam, integrating perspectives from healthcare professionals, PLWH, and their caregivers. Qualitative data were collected through five focus group interviews involving ten PLWH, nine caregivers, and eight healthcare providers in Hanoi, Vietnam, in March 2023. Thematic analyses uncovered recurring patterns and themes across the three participant groups.

Exploring the experience of stigma among children and adolescents with epilepsy in China: A qualitative study.

Objective: Epilepsy-related stigma negatively affects the lives of children and adolescents. This study aims to explore the experience of stigma among children and adolescents with epilepsy in China.

Methods: This study used purposive sampling to select children and adolescents aged 10-18 diagnosed with epilepsy.

Pulsed Ultrasound-Mediated Drug Delivery Enhancement Through Human Sclera.

Purpose: The purpose of this study was to characterize whether pulsed ultrasound (PUS) affects transscleral drug delivery.

Methods: Fluorescein sodium (NaF, 376 Da) and fluorescein isothiocyanate-conjugated dextran 40 (FD-40, 40 kDa) were used as model drugs. Human sclera grafts were placed in modified Franz diffusion cells and were treated by PUS (1 megahertz [MHz], 0.

Control of a New Financial Risk Contagion Dynamic Model Based on Finite-Time Disturbance.

With the widespread application of chaotic systems in many fields, research on chaotic systems is becoming increasingly in-depth. This article first proposes a new dynamic model of financial risk contagion based on financial principles and discusses some basic dynamic characteristics of the new chaotic system, such as equilibrium points, dissipativity, Poincaré diagrams, bifurcation diagrams, etc. Secondly, with the consideration of privacy during data transmission, the method was designed to protect the privacy of controlled systems in finite time based on perturbation.