Publications by authors named "Qing Wei"

Background: Maternal colonization with Group B Streptococcus (GBS) disrupts the vaginal microbiota, potentially affecting infant microbiota assembly and growth. While the gut microbiota's importance in infant growth is recognized, the specific effects of maternal GBS on growth remain unclear. This study aimed to explore the effects of maternal vaginal GBS during pregnancy on early infant growth, microbiome, and metabolomics.

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  • Chronic lymphocytic leukemia (CLL) is a slow-growing B-cell cancer that typically responds well to treatments, but some cases can be complicated by genetic rearrangements.
  • This report highlights a specific case of CLL that developed an IGH::CCND1 rearrangement along with mutations linked to treatment resistance during disease progression.
  • The findings indicate that these mutations are secondary changes within the CLL cells, showcasing how treatment can lead to adaptive changes in the cancer, ultimately resulting in resistance to therapy.
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The adaptation of lung cells to high-altitude environments represents a notable gap in our understanding of how animals cope with hypoxic conditions. Alveolar epithelial cells type II (AEC II) are crucial for lung development and repair. However, their, specific role in the adaptation of yaks to high-altitude environments remains unclear.

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To investigate the protective mechanism of dexmedetomidine (DEX) on adipose-derived stromal cells (ADSCs) under oxidative stress model and its promotion effect on the retention rate of adipose granule transplantation by and experiments. The experiment was divided into control group, model group (ADSCs + HO+normal serum), DEX group (ADSCs + H0+DEX drug-containing serum), autophagy agonist group (ADSCs + HO+rapamycin (RAP)+normal serum), RAP + DEX group (ADSCs + HO+normal serum), RAP + DEX drug-containing serum), autophagy inhibitor group (ADSCs + HO+chloroquine (CQ)+normal serum), CQ + DEX group (ADSCs + HO+CQ + DEX drug-containing serum). HO-1, GSH-PX, SOD and CAT in ADSCs under oxidative stress model were measured.

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  • - The study highlights the urgent issue of antibiotic resistance gene (ARG) spread in the environment, focusing on the impact of the herbicide napropamide (NAP) on plasmid transfer between bacteria.
  • - It found that R-NAP significantly enhances plasmid transfer efficiency from E. coli to Bacillus subtilis compared to its S-enantiomer, particularly at a concentration of 5 mg/L, while also affecting bacterial structures and increasing membrane permeability.
  • - The research identifies specific genes involved in this transfer and suggests that careful management of herbicides like R-NAP is necessary in agricultural settings to prevent the spread of ARGs, particularly in fields treated with livestock manure.
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To improve the management level of general anesthesia during bronchoscopy in the children with diffuse alveolar hemorrhage (DAH). A retrospective study was conducted in the children with DAH who had performed bronchoscopy under general anesthesia with spontaneous respiration by face mask ventilation initially from June 2021 to June 2022 in our hospital. (1) Thirty-four children who had underwent 38 bronchoscopy procedures were included.

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  • The study investigates how poultry (specifically laying hens) adapt their metabolism in response to energy deprivation caused by fasting and refeeding practices.
  • Ninety hens were divided into three groups: a control group with constant feeding, a fasting group, and a refeeding group, with various analyses of their bodily responses conducted after the treatment.
  • Findings revealed that fasting led to significant changes in body weight, gut microbiota composition, and liver gene expression, all of which were reversed by refeeding, indicating a complex interaction between the gut, liver, and metabolic processes.
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Background: Ureaplasma spp. can be classified into different serovars. It is unknown whether distinct serovars are associated with clinical signs and symptoms.

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  • Long-axis PET technology improves the sensitivity and counting performance for low-dose, rapid, and whole-body imaging in research settings.
  • The study presents a new long-axis PET system designed for rats, with a specific focus on measuring its performance following established NEMA standards.
  • Results show that this PET system has high sensitivity and excellent image quality, demonstrating its potential for effective whole-body dynamic imaging in animal studies.
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The link between benzene, toluene, ethylbenzene, xylene, and styrene (BTEXS) exposure and hearing loss (HL) is not well-established. This study investigated 1694 petrochemical workers in southern China to examine the effects of BTEXS urinary metabolites on auditory function, considering oxidative stress (OS) as a potential cause. Using generalized linear models, elastic net regression, and quantile g-computation, we evaluated the single and combined effects of BTEXS, OS indicators, and HL.

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Collagen is crucial for tissue structure, functional maintenance, and cellular processes such as proliferation and differentiation. However, the specific changes in collagen expression and its associated genes in the lung tissues of yaks at high altitudes and their relationship with environmental adaptation remain poorly understood. Studying differences in the content of collagen fibers and gene expression between yaks at high (4,500 m) and low (2,600 m) altitudes, as well as between cattle at low altitudes (2,600 m).

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  • Younger premenopausal women show a higher likelihood of developing ovarian metastases from gastric cancer compared to other cancers, but the exact biological processes are not fully understood.
  • Researchers used single-cell RNA sequencing on tumor samples from gastric cancer patients with ovarian metastases, discovering that ovarian fibroblasts express high levels of estrogen receptors and midkine, which facilitates communication with tumor cells through a specific signaling pathway.
  • The study suggests that estrogen influences ovarian fibroblasts to secrete midkine, which promotes gastric cancer cell migration and invasion, potentially leading to new treatment approaches for ovarian metastases in gastric cancer.
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This work proposed an approach to multi-component non-metallic materials, namely regular polygonal paper honeycomb sandwich tubes filled with polyethylene (PE) foam, and focused on the influence of drop impact parameters and structural parameters on the deformation characteristics and energy absorption of the filled tubes. Axial drop impact tests were employed to exert drop impact loading on cross-sections of the specimens with a square drop weight. The results showed that the X-direction filled tube (X-DFT) had a higher crushing strength and yield strength than that of the Y-direction filled tube (Y-DFT).

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  • MSS/pMMR colorectal cancer patients typically do not respond to PD-1/PD-L1 blockade, and understanding why could improve immunotherapy outcomes.* -
  • This study used a mouse model of subcutaneous CRC to investigate the tumor microenvironment through single-cell RNA sequencing, revealing distinct immune cell compositions and potential resistance mechanisms.* -
  • Findings suggest that enhancing immune cell presence in the tumor may improve effectiveness of PD-L1 blockade, indicating strategies to alter tumor cell diversity could mitigate resistance to immunotherapy.*
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  • Hepatocellular carcinoma (HCC) is a serious cancer associated with high rates of morbidity, and its progression is influenced by the epithelial-mesenchymal transition (EMT) linked to tumor-associated macrophages (TAMs).
  • The study investigated the relationship between a specific circular RNA (has_circ_0000092), various proteins, and how they interact within the immune environment of HCC to enhance the EMT process.
  • Results showed that has_circ_0000092 is highly expressed in HCC cells, promoting M2 polarization of macrophages through the regulation of IL24 via SMC1A, suggesting a potential mechanism for HCC metastasis and recurrence.
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A new scoring system termed sepsis-induced coagulopathy (SIC) has been proposed to diagnose early sepsis-induced disseminated intravascular coagulation (DIC). This study performed DIC-related analyses in patients with confirmed SIC. Data from the intensive care unit (ICU) departments of the three hospitals between 2020 and 2022 were retrospectively analyzed.

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Lanthanide-doped upconversion nanoparticles (Ln-UCNPs) have been considered promising materials for various fields, such as biomedical and industrial applications. However, data and reports regarding its toxicity and environmental risks are scarce. Under these circumstances, data must be obtained to fully understand potential toxicity and adverse outcome pathways.

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  • Anti-interferon-γ autoantibodies (AIGAs) syndrome increases susceptibility to opportunistic infections, and a study was conducted to analyze clinical characteristics and treatment responses over a two-year period.
  • Among 238 patients, those positive for AIGAs exhibited higher rates of infections, shorter progression-free survival, and elevated inflammatory markers compared to those negative for AIGAs.
  • Three subtypes of AIGAs-positive patients were identified, with glucocorticoid treatment effectively reducing AIGAs levels and immune indices in a significant number of cases, indicating potential benefits of treatment for specific groups.
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  • Metastatic colorectal cancer (mCRC) is increasingly linked to various genomic alterations beyond known factors, and this study focuses on identifying targetable changes for personalized treatment in a Chinese mCRC patient cohort.
  • A total of 500 patients underwent genomic profiling using targeted sequencing across 520 genes, revealing significant prevalence of mutations, including ones associated with potential therapy implications.
  • The findings indicated specific mutations and alterations correlated with prognosis, highlighting that some mutations lead to poorer survival rates, emphasizing the need for tailored therapies based on genomic profiling.
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  • Cytogenomic characterization is essential for diagnosing and treating acute myeloid leukemia (AML), and this study evaluated the effectiveness of optical genome mapping (OGM) among 159 AML patients.
  • OGM demonstrated over 99% sensitivity in detecting clinically relevant cytogenetic abnormalities, and it revealed additional genetic alterations in nearly half of the patients studied, including new fusion genes and chromosomal rearrangements.
  • The findings suggest that OGM could significantly improve AML classification and risk assessment, influencing treatment decisions and trial eligibility, especially by identifying diagnostic information that traditional methods may miss.
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Transition metal phosphide/sulfide (TMP/TMS) heterostructures are attractive supercapacitor electrode materials due to their rapid redox reaction kinetics. However, the limited active sites and weak interfacial interactions result in undesirable electrochemical performance. Herein, based on constructing the NiCo-LDH template on Ni-MOF-derived NiP/NC, NiP/NC@CoNiS with a porous heterostructure is fabricated by sulfurizing the intermediate and is used for supercapacitors.

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