Publications by authors named "Qing Hui Wu"
Article Synopsis
- - Over the last 30 years, miniaturized percutaneous nephrolithotomy (mPCNL) has gained popularity due to its potential to reduce complications compared to standard procedures, but there's still debate over best practices and management strategies that hinders wider use.
- - An international panel of urology experts developed a consensus document on mPCNL to provide a comprehensive framework for practice, which included reviewing literature, identifying research gaps, and conducting surveys to gather expert opinions.
- - The study revealed 58 key questions on mPCNL practices, and consensus was achieved on 30 questions, affirming mPCNL as an effective technique for treating upper urinary tract stones in both adults and children.
Article Synopsis
- This study investigates how the cancer treatment drug abiraterone affects the liver transport proteins OATP1B1 and OATP1B3, focusing on the use of coproporphyrin I (CP-I) as a biomarker to measure these effects.
- The results showed that abiraterone inhibits the uptake of CP-I through OATP1B3 but not OATP1B1, with in vitro tests revealing a moderate inhibition constant and clinical simulations indicating no significant drug interaction.
- Overall, the findings suggest that the risk of interaction between abiraterone and other drugs that rely on OATP1B transporters is low, meaning that OATP1B3 does
Cardiovascular risks of androgen receptor targeted agents in prostate cancer: a systematic review and meta-analysis.
Prostate Cancer Prostatic Dis
September 2024
Article Synopsis
- Androgen receptor targeted agents (ARTA) are increasingly used in prostate cancer treatments, leading to improved survival but also heightened concerns over cardiovascular side effects.
- A meta-analysis revealed that ARTA significantly increases the incidence of cardiac-related issues, such as hypertension, ischaemic heart disease, and arrhythmia, but does not seem to raise the rates of cardiac arrests or deaths.
- Understanding these risks helps inform better management strategies for patients on ARTA, potentially involving cardiologists to monitor heart health closely.
Background: Magnetic resonance imaging (MRI) scans are increasingly first-line investigations for suspected prostate cancer, and essential in the decision for biopsy. 5-alpha reductase inhibitor (5-ARI) use has been shown to reduce prostate size and prostate cancer risk. However, insufficient data exists on how 5-ARI use affects MRI findings and yield of biopsy.
View Article and Find Full Text PDFPurpose: Cxbladder tests are urinary biomarker tests for detection of urothelial carcinoma. We developed enhanced Cxbladder tests that incorporate DNA analysis of 6 single nucleotide polymorphisms for the and genes, in addition to the current 5 mRNA biomarkers and clinical risk factors.
Materials And Methods: Two multicenter, prospective studies were undertaken in: (1) U.
Quantifiable erectile dysfunction (ED) diagnosis involves the monitoring of rigidity and tumescence of the penile shaft during nocturnal penile tumescence (NPT). In this work, we introduce Erectile Dysfunction SENsor (EDSEN), a home-based wearable device for quantitative penile health monitoring based on stretchable microtubular sensing technology. Two types of sensors, the T- and R-sensors, are developed to effectively measure penile tumescence and rigidity, respectively.
View Article and Find Full Text PDFWithin the heterogeneous population of patients with bacillus Calmette-Guérin failure, there are clear differences in prognosis and therapy with regard to the timeline when bacillus Calmette-Guérin failure occurred. There are a variety of classifications which include bacillus Calmette-Guérin refractory disease, relapsing, unresponsive, and intolerant. Further profiling of these patients may help to shed light on other forms of therapy that are less radical.
View Article and Find Full Text PDFIntra-abdominal pressure (IAP) is closely correlated with intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) diagnoses, indicating the need for continuous monitoring. Early intervention for IAH and ACS has been proven to reduce the rate of morbidity. However, the current IAP monitoring method is a tedious process with a long calibration time for a single time point measurement.
View Article and Find Full Text PDFObjectives: To investigate plasma and urinary kynurenine (KYN)-tryptophan (TRP) ratios in bladder cancer, expression of indoleamine 2,3-dioxygenase 1 (IDO1) in relation to tryptophan 2,3-dioxygenase (TDO2) in bladder tumour, and the correlation of KYN-TRP ratio with bladder tumour burden.
Methods: Metabotyping of the TRP-KYN metabolic axis was performed via a clinical case-control study. Expression of IDO1 and TDO2 was measured in human biopsied tissues.
To develop a strategy to improve response to bacillus Calmette-Gueri (BCG) using cytokine gene therapy ( + ). MB49-PSA tumor-bearing C57BL/6N mice were assigned into four groups: control; + therapy; BCG therapy or combined therapy ( + and BCG). In schedule 1, cytokine gene therapy was delivered before BCG therapy (eight instillations).
View Article and Find Full Text PDFCystoscopy is considered the gold standard for the clinical diagnosis of human bladder cancer (BC). As cystoscopy is expensive and invasive, it may compromise patients' compliance and account for the failure in detecting recurrent BC in some patients. In this paper, we investigated the role of urinary metabonomics in the diagnosis of human BC.
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