Publications by authors named "Qing Guan"

Cuproptosis represents a new type of cell death that intricately associated with copper homeostasis and protein lipoylation. The cuproptosis suppression has been characterized in the hypoxic tumor microenvironment (TME). Here we reveal that hypoxia inducible factor-1α (HIF-1α) is a driver of cuproptosis resistance in solid tumor.

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Tuberculosis (TB) is one of the ten major factors threatening human life and health. At present, many factors limit the application of existing anti-tuberculosis drugs, such as a small range of available drug options, poor treatment compliance, and severe toxic and side effects. It is extremely urgent to develop novel anti-tuberculosis drugs.

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Resistant starch (RS) refers to starch varieties that resist digestion by human digestive enzymes. Owing to its distinctive physicochemical attributes and functional capabilities, RS has gained a wide range of applications as a dietary fiber and prebiotic. In terms of structure and functions, RS can be categorized into five distinct types: RS1 through RS5.

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Background: Perimenopausal women are a high-risk group for gynecological cancers; however, the spatiotemporal heterogeneity in prevalence and its association with socioeconomic development have not been fully explored. This study aimed to analyze the global burden of cervical, ovarian, and uterine cancers among perimenopausal women, examine health inequalities, and investigate their relationship with socioeconomic levels.

Methods: We assessed the disease burden of gynecological cancers in perimenopausal women using the 2019 Global Burden of Disease study (GBD2019) data, utilizing prevalence and Years of Life Lost (YLL) rates.

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Objective: To explore the knowledge-action gap regarding health behaviors and their influencing factors among patients with metabolic dysfunction-associated fatty liver disease (MAFLD), using the Health Belief Model as a theoretical framework.

Design: A qualitative approach was adopted, involving semistructured interviews with individuals with MAFLD.

Setting: Participants were recruited from a community hospital and a tertiary hospital in Nanjing, China, between July and October 2022.

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Postdoctoral training is a career stage often described as a demanding and anxiety-laden time when many promising PhDs see their academic dreams slip away due to circumstances beyond their control. We use a unique dataset of academic publishing and careers to chart the more or less successful postdoctoral paths. We build a measure of academic success on the citation patterns two to five years into a faculty career.

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Aim: This study examined the diabetes burden in Fujian Province, China, from 1990 to 2019, comparing it with China and global levels to inform policymakers.

Materials And Methods: We used data from GBD 2019 to analyse diabetes prevalence, death, and disability-adjusted life-years (DALYs). We assessed the average annual percentage change (AAPC) and estimated the impact of 17 risk factors.

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Previous research using the Attention Network Test (ANT) paradigm has indicated that older adults with mild cognitive impairment (MCI) experience declines in attentional performance across the three core networks: alerting, orienting, and executive control, primarily focusing on main effects. The present study sought to expand these findings by exploring whether interactions between these networks are also affected in the presence of MCI. To achieve this, we used the Revised Attention Network Test (ANT-R) to examine both the individual attentional networks and their interactions in 21 older adults with MCI and 27 healthy controls (HCs) matched on demographic variables.

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Anaplastic thyroid cancer (ATC) is the most lethal tumor arising from thyroid follicular epithelium. Lenvatinib is an off-label use option for ATC patients in many countries but an approved prescription in Japan. However, lenvatinib resistance is a substantial clinical challenge.

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The preclinical stage of Alzheimer's Disease (AD) holds great potential for intervention, therefore, it is crucial to elucidate the neural mechanisms underlying the progression of subjective cognitive decline (SCD). Previous studies have predominantly focused on the neural changes in the cerebrum associated with SCD, but have relatively neglected the cerebellum, and its functional relationship with the cerebrum. In the current study, we employed dynamic functional connectivity and large-scale brain network approaches to investigate the pathological characteristics of dynamic brain states and cerebro-cerebellar collaboration between SCD (n = 32) and the healthy elderly (n = 29) using resting-state fMRI.

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Article Synopsis
  • * Researchers sequenced the sika deer genome and analyzed gene expression and chromatin accessibility to identify key transcription factors involved in antler regeneration.
  • * A new model, cTOP, was developed to integrate various data types, revealing critical factors for stem cell activation and differentiation during the regeneration process.
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Extensive behavioral and pedagogical studies emphasize the negative impact of foreign language reading anxiety on foreign language reading. This study investigated whether foreign language reading anxiety is correlated with dysregulation of attentional allocation while foreign language reading. We used event-related potential (ERP) indices as biomarkers to examine attention allocation between groups with high foreign language reading anxiety (HFLRA) and low foreign language reading anxiety (LFLRA) using a cue-target paradigm under conditions that posed high (valid condition) or low (invalid condition) expectations on target location.

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Background: Healthcare organizations are under pressure to improve services because of an aging population and increasing healthcare demands. Lean healthcare management focuses on improving service quality and efficiency under the condition of limited resources, but it may overlook patients' emotional needs and experiences, especially in developing countries. This study advocates integrating medical humanities with lean healthcare to develop a patient-centered service model.

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Objectives: Citrate, oxalate and cystine in 24-h urine are considered to be associated with the incidence and recurrence risk of urinary stone disease (USD). An evaluation of the LC-MS/MS kit for simultaneous quantification of the three analytes was undertaken.

Design: & Methods: The analytical performance of the kit was investigated based on FDA, EMA and CLSI guidelines.

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Background: Abnormal arachidonic acid metabolism in the tumor microenvironment is closely related to cancer progression; however, thyroid cancer was rarely researched.

Methods: Through lipidomic analysis, we disclosed that dysregulated arachidonic acid metabolism plays dual effects on thyroid cancer. The promoting role of arachidonic acid in the progression of thyroid cancer cells was evaluated utilizing cell viability (CCK-8 assay) and transwell invasion assays, confirmed by corresponding inhibitors.

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Article Synopsis
  • The study investigates how changes in high-density lipoprotein cholesterol (HDL-C) levels are linked to the risk of developing metabolic dysfunction-associated fatty liver disease (MAFLD).
  • Researchers analyzed data from 1507 participants to identify different patterns of HDL-C levels and their correlation with the onset of MAFLD over time.
  • Results indicated that individuals with persistently low HDL-C levels had a significantly higher risk of developing MAFLD, highlighting the importance of monitoring HDL-C as a preventive measure.
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Aims: Age is a major risk factor for differentiated thyroid cancer (DTC); however, the mechanisms underlying aging-regulated progression of DTC remains unclear.

Methods: Based on multi-omics data (transcriptional files, somatic mutation files, methylation files) derived from the TCGA database, we comprehensively investigated the genomic and biological features associated with aging in patients with DTC.

Results: We confirmed that age was an independent risk factor for overall survival and progression-free survival of patients with DTC, and confirmed that 55 years of age (adopted in the 8th AJCC staging system) is an appropriate cutoff for patients with DTC rather than 45 years (adopted in the 7th AJCC staging system).

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Background: A deep convolutional neural network (DCNN) model was employed for the differentiation of thyroid nodules diagnosed as atypia of undetermined significance (AUS) according to the 2023 Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The aim of this study was to investigate the efficiency of ResNeSt in improving the diagnostic accuracy of fine-needle aspiration (FNA) biopsy.

Methods: Fragmented images were used to train and test DCNN models.

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Attention control is the common element underlying different executive functions. The backward Masking Majority Function Task (MFT-M) requires intensive attention control, and represents a diverse situation where attentional resources need to be allocated dynamically and flexibly to reduce uncertainty. Aiming to train attention control using MFT-M and examine the training transfer effects in various executive functions, we recruited healthy young adults (n = 84) and then equally randomized them into two groups trained with either MFT-M or a sham program for seven consecutive days.

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Article Synopsis
  • * Results show that lower foreign language reading anxiety (LFLRA) correlates positively with better reading performance, while those with high anxiety (HFLRA) demonstrate notable differences in brain activity, particularly in the N170 component which is linked to language processing.
  • * LFLRA individuals exhibit faster and more efficient processing of foreign languages compared to HFLRA individuals, who struggle with lexical processing, suggesting that anxiety negatively impacts their ability to read in a foreign language.
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24-hour urinary free cortisol (UFC) is considered as the first-line test for screening and diagnosis of Cushing's syndrome. Although 24-hour UFC assay has been extensively studied by liquid chromatography-tandem mass spectrometry (LC-MS/MS), an accurate assay coupled with a reliable sample preparation procedure and a method-specific reference interval would be very important for reasonable diagnosis. In this study, a simple dilute and shoot method has been proposed for UFC determination by LC-MS/MS.

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Trust propensity (TP) relies more on social than economic rationality to transform the perceived probability of betrayal into positive reciprocity expectations in older adults with normal cognition. While deficits in social rationality have been observed in older adults with mild cognitive impairment (MCI), there is limited research on TP and its associated resting-state functional connectivity (RSFC) mechanisms in this population. To measure TP and related psychological functions (affect, motivation, executive cognition, and social cognition), MCI (n = 42) and normal healthy control (NHC, n = 115) groups completed a one-shot trust game and additional assessments of related psychological functions.

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Fairness plays a crucial role in children's social life and has garnered considerable attention. However, previous research and theories primarily examined the development of children's fairness behaviors in the conflict between self-interest motivation and fairness-complying motivation, neglecting the influence of advantage-seeking motivation. Moreover, despite the well-established role of gain/loss frame in human decision-making, it remains largely unclear whether the framing effect modulates fairness behaviors in children.

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The low detection rate of primary tumors by current diagnostic techniques remains a major concern for patients with head and neck cancer of unknown primary (HNCUP). Therefore, in this study, we aimed to investigate the potential role of Ga-labeled fibroblast activation protein inhibitor (Ga-FAPI) PET/CT compared with F-FDG PET/CT for the detection of primary tumors of HNCUP. In this prospective comparative imaging trial conducted at Fudan University Shanghai Cancer Center, 91 patients with negative or equivocal findings of a primary tumor by comprehensive clinical examination and conventional imaging were enrolled from June 2020 to September 2022.

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Background: Limited understanding exists regarding the influences of engagement, persistence and adherence on the efficacy of cognitive training for age-related cognitive decline and neurodegenerative cognitive impairment.

Methods: This study conducted a meta-analysis of randomised controlled trials (RCTs). We systematically searched MEDLINE, PubMed, Web of Science, Embase and CINAHL databases from 1 January 2012 to 13 June 2023, and included RCTs assessing the effects of cognitive training in older adults, both with and without cognitive impairment.

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