Spatial proteomics landscape and immune signature analysis of renal sample of lupus nephritis based on laser-captured microsection.

Objective: We aimed to reveal a spatial proteomic and immune signature of kidney function regions in lupus nephritis (LN).

Material And Methods: The laser capture microdissection (LCM) was used to isolate the glomerulus, tubules, and interstitial of the kidney from paraffin samples. The data-independent acquisition (DIA) method was used to collect proteomics data.

Clinical findings, diagnosis and therapy of patent ductus venosus in children: a case series.

Background: Patent ductus venosus (PDV) is a rare form of congenital portosystemic shunt. Because of the diversity of clinical symptoms and insufficient knowledge of this condition, clinicians often fail to perform targeted examinations, resulting in missed diagnoses and misdiagnoses. This study summarized the clinical and radiological findings, as well as surgical methods, of PDV with the aim of improving early diagnosis and guiding treatment.

Cranial fasciitis in children: clinicoradiology features and management.

Background: Cranial fasciitis (CF) is a rare benign fibroproliferative lesion of the skull. To date, the summarized radiologic characteristics and the subtype of the disease have not been reported. our purpose was to summarize the characteristic clinicoradiology features and management of CF and to improve the knowledge of radiologists and clinicians.

Echocardiographic evaluation of total anomalous pulmonary venous connection: Comparison of obstructed and unobstructed type.

This study aims to compare the differences between obstructed and unobstructed total anomalous pulmonary venous connection (TAPVC) using echocardiography, and to evaluate the clinical and echocardiographic parameters associated with pulmonary venous obstruction (PVO).We conducted a retrospective study of 70 patients with TAPVC between 2014 and 2019. The morphologic and hemodynamic echocardiographic parameters of patients were observed and measured, and the parameters between obstructed and unobstructed TAPVC were compared.

Differential Expression Study of Lysine Crotonylation and Proteome for Chronic Obstructive Pulmonary Disease Combined with Type II Respiratory Failure.

Introduction: The modification of lysine crotonylation (Kcr) is another biological function of histone in addition to modification of lysine acetylation (Kac), which may play a specific regulatory role in diseases.

Objectives: This study compared the expression levels of Kcr and proteome between patients with chronic obstructive pulmonary disease (COPD) combined with type II respiratory failure (RF) to study the relationship between Kcr, proteome, and COPD.

Methods: We tested the Kcr and proteome of COPD combined with type II RF and normal control (NC) using croton acylation enrichment technology and liquid chromatography tandem mass spectrometry (LC-MS/MS) with high resolution.

Proteomic analysis of differentially expressed proteins in the serum of patients with acute renal allograft rejection using iTRAQ labelling technology.

Transplantation is currently the best treatment for patients with end‑stage renal disease. However, acute rejection (AR) is the major source of failure in renal transplantation. The current best practice for the diagnosis of AR involves renal biopsy, but it is invasive, time‑consuming, costly and inconvenient.

Dynamic Metabolomics Study of the Bile Acid Pathway During Perioperative Primary Hepatic Carcinoma Following Liver Transplantation.

BACKGROUND There are many situations of abnormal metabolism influencing liver graft function. This study aims to provide data for the development of liver function recovery after liver transplantation by dynamically analyzing metabolites of bile acids pathway in serum. MATERIAL AND METHODS A comprehensive metabolomics profiling of serum of 9 liver transplantation patients before transplantation, on the 1st, 3rd, and 7th days after liver transplantation, and healthy individuals were performed by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS).

Differential expression profile study and gene function analysis of maternal foetal-derived circRNA for screening for Down's syndrome.

Recent studies have shown that circular RNAs (circRNAs) exhibit differential expression in certain diseases. However, to the best of our knowledge, maternal fetal-derived circRNAs and mRNAs associated with Down's syndrome (DS) have not yet been investigated. A total of 12 umbilical cord blood samples were collected from pregnant women, including six women carrying fetuses with DS (diagnosed by G-banding karyotype analysis), and six women carrying fetuses without DS.

The impact of target dosimetry on patients' locoregional recurrence in nasopharyngeal carcinoma: A propensity score-matched analysis.

Purpose: To analyze the impact of target dosimetry using propensity score matching (PSM) on patients' locoregional recurrence for nasopharyngeal carcinoma (NPC) and to find significant dose-volume factors of recurrence.

Methods: Sixty-eight nasopharyngeal carcinoma (NPC) patients with recorded locoregional recurrence were enrolled in this study. These patients were treated with IMRT in 2009-2010 in our department.

Case Report: Rare Presentation of Multivisceral Echinococcosis.

Cystic echinococcosis (CE) is a common, chronic, and endemic zoonotic disease usually localized in a single organ; multivisceral cases are rare, especially outside the liver or lung. Here, we describe an unusual case of a 43-year-old Tibetan man with echinococcosis of the infratemporal fossa, heart, liver, pancreas, abdomen, and pelvic cavity. He only presented with diminished vision of the left eye, especially when chewing.

The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma.

Recent studies have shown that circular ribonucleic acids have differential expression in some diseases. This study compared the expression levels of five circular ribonucleic acids between patients of primary hepatic carcinoma following liver transplantation and healthy individuals for searching a new diagnostic biomarker about primary hepatic carcinoma. We chose differentially expressed targeted circular ribonucleic acids according to fold change ≥2.

Radiomic features of pretreatment MRI could identify T stage in patients with rectal cancer: Preliminary findings.

Background: Recent studies have shown that magnetic resonance (MR) radiomic analysis is feasible and has some value in identifying tumor characteristics, but there are few data regarding the role of MR-based radiomic features in rectal cancer.

Purpose: The aim of this study was to determine whether radiomic features extracted from T -weighted imaging (T WI) can identify pathological features in rectal cancer.

Study Type: Retrospective study.

[A Non-Destructive Study of Printing Materials of an Imperial China Green Engraved Coiling Dragon Stamp].

Non-destructive measurement methods including video microscopy (VM), Raman spectrometer (RS), and scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS) were employed to analyze the printing materials of a green curled-up dragon stamp sample from the late Qing Dynasty in terms of the paper and ink. The results indicated that the plate-making process of the sample belonged to handcrafted gravure while the slender and dense paper fiber with no coating, watermark, or gumming. Elements of Al and Si were inspected in fillers of paper, therefore, it could be inferred that kaolin (Al2O3·2SiO2·2H2O) was the filler of paper.

[Non-Destructive Identification of Pigments Printed on the Bank Bill Issued in 1945].

Three-dimensional video microscopy, Raman spectrometer and scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS) were employed to analyze the pigments of various colors on a sample of bank bill issued in 1945. The results indicated that organic pigments including C. I.