LmCHS1 mediates pro-nymphal cuticle formation in Locusta migratoria embryogenesis.

The pro-nymphal cuticle, serving as a protective structure that facilitates environmental adaptation, is critical for insect embryonic development. However, the mechanisms governing its formation remain poorly understood. In this study, we investigated the important role of chitin synthase (LmCHS1) in the formation of the pro-nymphal cuticle during embryonic development in Locusta migratoria.

Development and evaluation of the digital PCR-based method for clinical monitoring of viral loads during severe fever with thrombocytopenia syndrome virus infection.

Background: Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) represents a novel bunyavirus that poses significant public health challenges. As a key prognostic indicator of clinical outcome, the viral load determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is relatively inaccurate and incomparable across different studies. Digital PCR (dPCR) has recently proved to be a more ideal tool for viral load assessment.

Effect of Ulva prolifera fragment size on the biomass of developing green algae.

Green tides are on the rise in the world's ocean recently, and Ulva is one of the most important genera to develop this marine disaster. However, the rapid biomass accumulation of this genus is quite complex, so in this study we utilized the different sizes of U. prolifera fragments (0.

MedFILIP: Medical Fine-Grained Language-Image Pre-Training.

Medical vision-language pretraining (VLP) that leverages naturally-paired medical image-report data is crucial for medical image analysis. However, existing methods struggle to accurately characterize associations between images and diseases, leading to inaccurate or incomplete diagnostic results. In this work, we propose MedFILIP, a fine-grained VLP model, introduces medical image-specific knowledge through contrastive learning, specifically: 1) An information extractor based on a large language model is proposed to decouple comprehensive disease details from reports, which excels in extracting disease deals through flexible prompt engineering, thereby effectively reducing text complexity while retaining rich information at a tiny cost.

Remaining Useful Life Prediction Method for Stochastic Degrading Devices Considering Predictive Maintenance.

Predictive maintenance, recognized as an effective health management strategy for extending the lifetime of devices, has emerged as a hot research topic in recent years. A general method is to execute two separate steps: data-driven remaining useful life (RUL) prediction and a maintenance strategy. However, among the numerous studies that conducted maintenance and replacement activities based on the results of RUL prediction, little attention has been paid to the impact of preventive maintenance on sensor-based monitoring data, which further affects the RUL for repairable degrading devices.

Prevalence and genotypic identification of Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in farmed ostriches (Struthio camelus) by the Yellow River in Zhengzhou city, central China.

Background: Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi are significant zoonotic protozoa causing gastrointestinal diseases in humans and animals. However, their prevalence and genotypic characterization in ostriches (Struthio camelus) remain poorly understood.

Association of body weight and serum uric acid with Alzheimer's disease biomarkers and cognitive impairment.

BackgroundGiven the limited effective treatments for Alzheimer's disease (AD), obesity and serum uric acid (SUA) levels which are considered modifiable risk factors for dementia are of interest. However, research indicates conflicting results.ObjectiveWe aimed to further investigate the association of body weight (BW) and SUA with AD biomarkers and cognitive impairment.

Targeted mutation of / combined with the RUBY reporter enables an efficient two-line system for hybrid seed production in .

The recessive genic male sterility (RGMS) method has several benefits in hybrid seed production; however, it is seldom employed in industrial hybrid seed production owing to the difficulty of producing an ample number of pure male-sterile seeds. In this study, we present an efficient methodology for developing a two-line strategy to produce hybrid seed through targeted mutation of and in conjunction with the reporter in . In this method, male-sterile lines were successfully created directly from different elite rapeseed breeding lines through CRISPR/Cas9-mediated mutagenesis and enhanced -mediated transformation.

Reducing radiation-induced hypothyroidism by modified delineation of cervical lymphatic drainage area for nasopharyngeal carcinoma treated by intensity-modulated radiation Therapy: 3 years' experience.

Background And Purpose: Radiation-induced hypothyroidism (RIHT) is a late complication of intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC). We evaluated thyroid protection in NPC patients receiving IMRT using modified delineation (MD) of cervical lymphatic drainage areas, sparing the common carotid artery within the clinical target volume (CTV), to assess its impact on thyroid function and survival outcomes.

Materials And Methods: This retrospective cohort study included patients without metastatic lymph nodes at levels III and IV who received neck irradiation.

Enhanced Phytoextraction Technologies for the Sustainable Remediation of Cadmium-Contaminated Soil Based on Hyperaccumulators-A Review.

Heavy metal pollution in soil is a significant challenge around the world, particularly cadmium (Cd) contamination. In situ phytoextraction and remediation technology, particularly focusing on Cd hyperaccumulator plants, has proven to be an effective method for cleaning Cd-contaminated agricultural lands. However, this strategy is often hindered by a long remediation cycle and low efficiency.

Convergent-Diffusion Denoising Model for multi-scenario CT Image Reconstruction.

A generic and versatile CT Image Reconstruction (CTIR) scheme can efficiently mitigate imaging noise resulting from inherent physical limitations, substantially bolstering the dependability of CT imaging diagnostics across a wider spectrum of patient cases. Current CTIR techniques often concentrate on distinct areas such as Low-Dose CT denoising (LDCTD), Sparse-View CT reconstruction (SVCTR), and Metal Artifact Reduction (MAR). Nevertheless, due to the intricate nature of multi-scenario CTIR, these techniques frequently narrow their focus to specific tasks, resulting in limited generalization capabilities for diverse scenarios.

Association of Reduced Folate Carrier G80A Polymorphism With Lung Cancer Susceptibility in a Hypertensive Population: A Nested Case-Control Study.

Background: Polymorphisms of the folate-associated one-carbon metabolism (OCM) pathway genes may regulate certain susceptibilities to cancer. G80A, a polymorphism in the reduced folate carrier (RFC) gene, may be associated with cancer risk, although the results obtained from previous studies have been inconsistent.

Objectives: This study aimed to evaluate the association of G80A with lung cancer among a Chinese population and to examine the potential effect modifiers.

Dyslipidemia in severe fever with thrombocytopenia syndrome patients: A retrospective cohort study.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is a rapidly progressive infectious disease triggered by a novel bunyavirus (SFTSV). Despite the critical role of host lipid metabolism in viral infections, research on dyslipidemia in SFTS remains limited.

Methods: This retrospective study included 433 SFTS patients, who were stratified into survival group (n = 365) and death group (n = 68) and who were treated at the Shandong Public Health Clinical Center from September 2021 to December 2023.

Adaptive Wiener process-based remaining useful life prediction method considering multi-source variability.

Existing remaining useful life (RUL) prediction methods considering multi-source variability were not applicable to the situation that the uneven measurement interval distribution and inconsistent measurement frequency of degrading equipment. This type of method also has ignored the variability of adaptive drift in the future degradation process. In view of this, based on adaptive Wiener process, the paper proposes a new nonlinear degradation method of the RUL prediction.

Effects of herbal formula on growth performance, apparent digestibility, antioxidant capacity, and rumen microbiome in fattening lambs under heat stress.

Heat stress (HS) causes severe economic losses in sheep industry worldwide. The objective of the present study was to investigate the effects of a herbal formula (HF) supplement on growth, digestibility, antioxidant capacity, and rumen microbes in fattening lambs under HS. The HF composed of four herbs was prepared based on the theory of compatibility of Chinese medicine "Jun-Chen-Zuo-Shi".

Lower serum LDL-C levels are associated with poor prognosis in severe fever with thrombocytopenia syndrome: a single-center retrospective cohort study.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease triggered by a novel bunyavirus (SFTSV). Characterized by fever, thrombocytopenia, leukocytopenia, and multiple organ dysfunction manifestations, its primary mode of transmission is through tick bites. Despite the critical role of lipid metabolism in viral infections, the role of lipids in SFTS remains unclear.

The role of exosome-shuttled miRNAs in heavy metal-induced peripheral tissues and neuroinflammation in Alzheimer's disease.

Heavy metal-induced neuroinflammation is a significant pathophysiologic mechanism in Alzheimer's disease (AD). Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of AD. Multiple miRNAs are differentially expressed in peripheral tissues after heavy metal exposure, and increasing evidence suggests that they are involved in AD progression by regulating microglial homeostasis.

Development and validation of a preoperative CT‑based radiomics nomogram to differentiate tuberculosis granulomas from lung adenocarcinomas: an external validation study.

Background: An accurate and non-invasive approach is urgently needed to distinguish tuberculosis granulomas from lung adenocarcinomas. This study aimed to develop and validate a nomogram based on contrast enhanced-compute tomography (CE-CT) to preoperatively differentiate tuberculosis granuloma from lung adenocarcinoma appearing as solitary pulmonary solid nodules (SPSN).

Methods: This retrospective study analyzed 143 patients with lung adenocarcinoma (mean age: 62.

Initiating PeriCBD to probe perinatal influences on neurodevelopment during 3-10 years in China.

Adverse perinatal factors can interfere with the normal development of the brain, potentially resulting in long-term effects on the comprehensive development of children. Presently, the understanding of cognitive and neurodevelopmental processes under conditions of adverse perinatal factors is substantially limited. There is a critical need for an open resource that integrates various perinatal factors with the development of the brain and mental health to facilitate a deeper understanding of these developmental trajectories.

Synthesis of 2,3-Dialkyl-5-hydroxybenzofurans via a One-pot, Three-step Reaction Sequence of 2-Monosubstituted 1,3-Diketones and 1,4-Benzoquinones.

An economical one-pot, three-step reaction sequence of readily available 2-monosubstituted 1,3-diketones and 1,4-benzoquinones has been explored for the facile access of 2,3-dialkyl-5-hydroxybenzofurans. By using cheap KCO and conc. HCl as the reaction promoters, the reaction occurs smoothly via sequential Michael addition, aromatization, retro-Claisen, deacylation, hemiketalization, and dehydration processes under mild conditions in a practical manner.

Conserved DNA sequence analysis reveals the phylogeography and evolutionary events of Akebia trifoliata in the region across the eastern edge of the Tibetan Plateau and subtropical China.

Background: The eastern edge of the Qinghai‒Tibet Plateau (QTP) and subtropical China have various regions where plant species originate and thrive, but these regions have been the focus of very few integrative studies. Here, we elucidated the phylogeographic structure of a continuous and widespread Akebia trifoliata population across these two regions.

Results: Sixty-one populations consisting of 391 genotypes were examined to assess population diversity and structure via network distribution analysis, maximum likelihood phylogenetic tree reconstruction, divergence time estimation, demographic history inference, and ancestral area reconstruction of both conserved internal transcribed spacer (ITS) and chloroplast (rps16) DNA sequences.

Influences of tobacco straw return with lime on microbial community structure of tobacco-planting soil and tobacco leaf quality.

Soil amendment is an important strategy for improving soil quality and crop yield. From 2014 to 2019, we conducted a study to investigate the effects of tobacco straw return with lime on soil nutrients, soil microbial community structure, tobacco leaf yield, and quality in southern Anhui, China. A field experiment was conducted with four treatments: straw removed (CK), straw return (St), straw return with dolomite (St + D), and straw return with lime (St + L).

Association between 19 medication use and risk of common cancers: A cross-sectional and Mendelian randomisation study.

Background: Previous studies have yielded inconsistent results concerning drug use and the risk of cancers. We conducted a large-scale cross-sectional study and a two-sample Mendelian randomisation (MR) study to reveal the causal effect between the use of 19 medications and the risk of four common cancers (breast, lung, colorectal, and prostate).

Methods: We obtained information on medication use and cancer diagnosis from National Health and Nutrition Examination Survey participants.