Publications by authors named "Qing Dai"

Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC). We established radiotherapy-resistant cell lines to explore the molecular mechanisms of radiotherapy resistance in CRC. HT29 and HCT116 cells were subjected to repeated irradiation at 2 Gy to establish these lines.

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Background: This study aimed to develop a new ultrasonographic dating formula to estimate gestational age (GA) based on fetal crown-rump length (CRL) in a Chinese population, evaluate model accuracy and compare its performance with established dating formulas.

Methods: A prospective, multicenter study was conducted across mainland China. Participants included healthy, low-risk women with spontaneously conceived singleton pregnancies and a regular menstrual cycle in the preceding year.

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The pathophysiology of primary open-angle glaucoma (POAG), the most prevalent glaucoma type, is poorly understood. Although it is well known that epigenetic factors affect the progression of POAG, the impact of β-hydroxybutyrylation (Kbhb) on POAG remains unknown. Based on POAG-related datasets (GSE27276, GSE4316, and GSE231749) retrieved from the Gene Expression Omnibus (GEO) database, four biomarkers (FABP5, GLS, PDLIM1, and TAGLN) with a diagnostic value for POAG were identified by combining differential expression analysis, machine learning algorithms, and receiver operating characteristic (ROC) analysis.

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Ultrafast plasmonics represents a cutting-edge frontier in light-matter interactions, providing a unique platform to study electronic interactions and collective motions across femtosecond to picosecond timescales. In the infrared regime, where energy aligns with the rearrangements of low-energy electrons, molecular vibrations, and thermal fluctuations, ultrafast plasmonics can be a powerful tool for revealing ultrafast electronic phase transitions, controlling molecular reactions, and driving subwavelength thermal processes. Here, the evolution of ultrafast infrared plasmonics, discussing the recent progress in their manipulation, detection, and applications is reviewed.

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Angio-based microvascular resistance (AMR) as a potential alternative to the index of microcirculatory resistance (IMR) and its relationship with microvascular obstruction (MVO) and other cardiac magnetic resonance (CMR) parameters still lacks comprehensive validation. This study aimed to validate the correlation between AMR and CMR-derived parameters and to construct an interpretable machine learning (ML) model, incorporating AMR and clinical data, to forecast MVO in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI). We enrolled 452 STEMI patients from Nanjing Drum Tower Hospital between 2018 and 2022, who received both PPCI and CMR.

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Fitting rate constants to Hyperpolarized [1-C]Pyruvate (HP C13) MRI data is a promising approach for quantifying metabolism in vivo. Current methods typically fit each voxel of the dataset using a least-squares objective. With these methods, each voxel is considered independently, and the spatial relationships are not considered during fitting.

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Objective: The objective of this study is to evaluate the efficacy and safety of jaktinib hydrochloride tablets (jaktinib), a Janus kinase inhibitor, in patients with active radiographic axial spondyloarthritis (r-axSpA).

Methods: Adults with active r-axSpA who met modified New York criteria and had an inadequate response to non-steroidal anti-inflammatory drugs were randomised 1:1:1 to receive jaktinib 75 mg two times per day, 100 mg two times per day, or placebo. The primary and key secondary endpoints were Assessment of SpondyloArthritis international Society 20 (ASAS 20) and ASAS 40 responses, respectively, at week 16.

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Ultrafast thermal switches are pivotal for managing heat generated in advanced solid-state applications, including high-speed chiplets, thermo-optical modulators, and on-chip lasers. However, conventional phonon-based switches cannot meet the demand for picosecond-level response times, and existing near-field radiative thermal switches face challenges in efficiently modulating heat transfer across vacuum gaps. To overcome these limitations, we propose an ultrafast thermal switch design based on pump-driven transient polaritons in asymmetric terminals.

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  • * In mice subjected to 48 hours of sleep deprivation, cTBS treatment was found to reduce oxidative stress and inflammation in hippocampal tissues by lowering malondialdehyde levels and increasing superoxide dismutase activities.
  • * cTBS also mitigated excessive autophagy and promoted antioxidant capacity through the activation of the Nrf2 pathway, demonstrating its potential in reversing cognitive impairments caused by sleep deprivation.
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  • The study is an observational cohort aimed at identifying different classes of disability trajectories over a six-month period for individuals with spinal cord injuries (SCI) after hospitalization and examining predictive factors like psychosocial resources.
  • Conducted across three Class III hospitals in China, the study utilized the WHO Disability Assessment Schedule (WHO-DAS 2.0) and gathered data on personal factors, levels of hope, PTSD, and social support by master's students.
  • Results revealed two main disability trajectories: a majority in the continuous high disability group and a small fraction in the low starting point stabilization group, with findings suggesting that factors like complete injury classification and depression are significant, while occupation and social support don't predict trajectory classification.
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Laser-lubricant interaction has been a critical reliability issue in a thermo-tribological system named heat-assisted magnetic recording, one of the next generation hard disk drive solutions to increasing data storage. The lubricant response under laser irradiation and the subsequent lubricant recovery are crucial to the system's reliability and longevity, however, they cannot be diagnosed locally and timely so far. Here, we propose a thermal scheme to in-situ characterize the mechanical laser-lubricant interaction.

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  • - TET2 gene mutations lead to myeloid malignancies by causing an open chromatin state, activating stem cell self-renewal genes, and disrupting normal DNA methylation processes.
  • - The study highlights how TET2 interacts with chromatin-associated retrotransposon RNA 5-methylcytosine (mC) and the protein MBD6 to control histone modifications that influence chromatin structure.
  • - Depleting MBD6 in TET2-deficient cells can block malignant cell proliferation and reverse some of the harmful effects of TET2 loss, indicating a potential target for therapies aimed at TET2 mutation-related cancers.
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  • Direct visualization of electron-electron interactions is crucial for enhancing the surface properties of graphene-based quantum materials.
  • The study uses scanning tunneling microscopy and spectroscopic techniques to analyze wave function distributions in twisted double bilayer graphene, confirming the presence of symmetry-breaking states.
  • A new localized electronic state with rotational symmetry breaking is discovered, showcasing increased anisotropy across different energy bands, providing deeper insights into the behavior of these materials under electric fields.
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  • - Nonlinear physics is a crucial area of research in modern physics and materials science, providing new ways to investigate unique physical phenomena and innovative applications beyond traditional linear methods.
  • - The review focuses on the nonlinear properties of synthetic quantum moiré superlattices, emphasizing effects like the nonlinear anomalous Hall effect, harmonic generation, and optical solitons.
  • - The article discusses future opportunities and challenges in this dynamic field, highlighting its potential impacts on fundamental physics and technological advancements.
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  • Recent studies highlight the connection between mRNA internal mG modifications and cell metabolism, particularly regarding cancer regulation, with the METTL1 protein playing a key role.
  • The IGF2BP family, specifically IGF2BP3, preferentially binds to mG modifications in mRNA, influencing transcript stability and degradation in cancer cells.
  • The TP53 transcript is shown to be mG-modified in glioblastoma, and adjusting IGF2BP3 levels or targeting mG modifications can affect cancer progression and how cells respond to chemotherapy.
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  • Patients with spinal cord injury (SCI) often experience challenges in sensory and motor recovery, leading to reliance on caregivers and decreased quality of life, which can be addressed through dyadic coping interventions for couples.
  • The study is a pilot randomized controlled trial involving 72 couples with SCI, comparing an intervention group receiving dyadic coping support alongside usual care to a control group receiving only usual care.
  • Primary outcomes will assess the feasibility and acceptability of the intervention, while secondary outcomes will measure quality of life, psychological distress, caregiver burden, marital satisfaction, and dyadic coping at three intervals: baseline, post-intervention, and after 8 weeks.
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  • Glaucoma, particularly primary open-angle glaucoma (POAG), is a major cause of vision loss, yet its underlying mechanisms remain unclear.
  • This study analyzed data from the GEO database to identify potential biomarkers for POAG through various methods, including machine learning and Mendelian randomization, ultimately finding three significant light stimulation-related biomarkers (RAB8A, PRG3, and SMAD3).
  • The findings not only reveal these biomarkers' diagnostic potential but also suggest connections between DNA methylation and POAG, paving the way for future research on the disease.
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  • Rheumatoid arthritis (RA) is a chronic autoimmune disease leading to joint inflammation and destruction, and iguratimod (IGU) is a new treatment option showing promise in China and Japan.
  • A clinical trial with 911 patients tested the efficacy of IGU alone, methotrexate (MTX) alone, and a combination of both over 52 weeks, assessing various disease activity indices and bone destruction.
  • Results indicated that IGU monotherapy achieved a similar effectiveness to MTX monotherapy, with a higher percentage of patients demonstrating improved symptoms at week 52, confirming IGU's potential as an effective alternative treatment for active RA.
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  • Pseudouridine (Ψ) is a common RNA modification found in various types of RNA, and understanding its function requires accurate detection methods.
  • A traditional method uses N-cyclohexyl-'-β-(4-methylmorpholinium)ethylcarbodiimide (CMC), but it has drawbacks like RNA degradation and time-consuming processes.
  • The new BIHIND method allows for efficient detection and quantification of Ψ sites in RNA, and can be integrated with quantitative PCR and next-generation sequencing for enhanced analysis.
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  • The quaternion cubature Kalman filter (QCKF) is widely used for attitude determination and positioning in UAV applications, but relies on the assumption of white Gaussian noise, which is not always present in real-world data.
  • Actual GNSS/SINS-IADPS data often involves non-Gaussian noise and has constraints related to quaternion normalization, leading to potential inaccuracies in the QCKF's estimates.
  • The proposed Gaussian sum quaternion constrained cubature Kalman filter (GSQCCKF) addresses these issues by using a Gaussian mixture model for noise approximation and a two-step projection method for quaternion normalization, resulting in improved estimation accuracy under non-Gaussian noise conditions.
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  • - The study focuses on understanding the assembly process of silk nanofibrils (SNFs), which are crucial for creating artificial silk fibers, but the mechanisms involved are not fully understood.
  • - Researchers utilize a graphene plasmonic infrared sensor and multi-scale molecular dynamics (MD) to analyze the secondary structure and evolution of silk fibroin (SF) at the nanoscale.
  • - Key findings reveal that silk fibroin transitions from an amorphous state to β-sheet-rich oligomers on graphene, which then combine to form SNFs, offering important insights for future silk-spinning technologies.
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Polaritons are well-established carriers of light, electrical signals, and even heat at the nanoscale in the setting of on-chip devices. However, the goal of achieving practical polaritonic manipulation over small distances deeply below the light diffraction limit remains elusive. Here, we implement nanoscale polaritonic in-plane steering and cloaking in a low-loss atomically layered van der Waals (vdW) insulator, α-MoO, comprising building blocks of customizable stacked and assembled structures.

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In this protocol, we present a facile nanoscale thermal mapping technique for electronic devices by use of atomic force microscopy and a phase change material GeSbTe. We describe steps for GeSbTe thin film coating, GeSbTe temperature calibration, thermal mapping by varying heater power, and thermal mapping by varying heating time. The protocol can be applied for resolving surface temperatures of various operational microelectronic devices with a nanoscale precision.

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  • The study aims to enhance the quality of MRI images and reduce biases in measuring liver fat content through a new method that allows for free-breathing scans instead of traditional breath-hold techniques.
  • Researchers developed a multi-echo, radial MRI method using advanced compressed sensing and performed tests on motion phantoms and patients with liver disease to validate its effectiveness.
  • Results showed that the new method significantly decreased measurement variations and required less scanning time compared to existing protocols, indicating it could be a more efficient approach for assessing liver health.
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