Development and validation of immune-based biomarkers and deep learning models for Alzheimer's disease.

Alzheimer's disease (AD) is the most common form of dementia in old age and poses a severe threat to the health and life of the elderly. However, traditional diagnostic methods and the ATN diagnostic framework have limitations in clinical practice. Developing novel biomarkers and diagnostic models is necessary to complement existing diagnostic procedures.

Effects of vegetation restoration and environmental factors on understory vascular plants in a typical karst ecosystem in southern China.

Understory vegetation is an important component in most forest ecosystems. It is very important for soil and water conservation in karst region, study on understory will provide valuable information for understanding the interaction mechanism between understory flora and karst environment. Thirty-two plots were sampled in three vegetation types along with a restoration gradient (shrubland, forest-shrub transition, and mixed-species broadleaf forest) in typical karst mountains in Southwest Guangxi, China.

[Impacts of digging Phascolosoma esculenta on the growth of mangrove Avicennia marina seedlings: a simulation study].

Digging Phascolosoma esculenta to increase income is one of the main causes leading to the degradation of China mangroves. In order to understand the impact mechanisms of digging P. esculenta on the mangrove growth and to select indicators to evaluate the mangrove health, a simulative study was conducted to clarify the impacts of digging depth, radian, and frequency on the growth of 1-year old Avicennia marina seedlings, with the indices seedling height, basal diameter, single leaf area, specific leaf area, total biomass, and dead root dry mass measured.

Highly diastereoselective enolate addition of O-protected alpha-hydroxyacetate to (S(R))-tert-butanesulfinylimines: synthesis of taxol side chain.

The taxol side chain (S(R),2R,3S)-N-tert-butanesulfinyl-O-Boc-3-phenylisoserine benzyl ester 4c was synthesized through a lithium enolate addition of O-Boc-alpha-hydroxyacetate benzyl ester 5c to benzylidene (S(R))-tert-butanesulfinamide 6a in excellent yield and diastereoselectivity. By similar approach, a series of enantiopure 3-substituted isoserine benzyl esters 4 useful for the semi-syntheses of taxol derivatives were also prepared in high to excellent yields and diastereoselectivities. The diastereoselective addition mechanism was discussed on the basis of the experimental observation.