Glycation gap is associated with macroproteinuria but not with other complications in patients with type 2 diabetes.

Objective: We investigated whether glycation gap (G-Gap), an index of intracellular glycation of proteins, was associated with diabetes complications.

Research Design And Methods: We measured concomitantly HbA1c and fructosamine in 925 patients with type 2 diabetes to calculate the G-Gap, defined as the difference between measured HbA1c, and fructosamine-based predicted HbA1c. Patients were explored for retinopathy, nephropathy, peripheral neuropathy, cardiac autonomic neuropathy (n = 512), and silent myocardial ischemia (n = 506).