Publications by authors named "QinLong Liu"

Article Synopsis
  • The study investigates the effects of a partial hepatectomy (PH) on liver regeneration, focusing on mitochondrial structure and function in a mouse model.
  • Changes observed post-surgery included mitochondrial swelling, a reduction in cristae, and an increase in cell proliferation as indicated by PCNA positivity.
  • A total of 30 differentially expressed genes (DEGs) linked to crucial processes like oxidative phosphorylation and nonalcoholic fatty liver disease (NAFLD) were identified, along with six key hub genes for further study.
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Background: Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors in the world, characterized by high incidence, high malignancy, and low survival rate. Currently, 1/4 of adults in the world suffer from Non-Alcoholic Fatty Liver Disease (NAFLD), with an incidence rate of 27% in Asia.

Methods: We used TCGA and GEO public database data sets to conduct weighted gene coexpression network analysis to identify relevant gene modules, defined the intersection of tumorigenesis-related modules and NASH development-related modules as shared genes, and then used single-factor Cox, LASSO, and multivariate Cox regression analysis screened out core shared genes and verified their prognostic value.

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Improving liver regeneration (LR) remains a medical issue, and there is currently a lack of safe and effective drugs for LR. Rhizoma Dioscoreae (SanYak, SY) is a traditional Chinese medicine. However, the underlying action mechanism of SY treatment for LR is yet to be fully elucidated.

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In the realm of obesity and overweight, the risk of chronic diseases significantly escalates, closely intertwined with inflammatory factors. Research suggests that specific exercise interventions, particularly aerobic exercise and resistance exercise, can have beneficial effects on inflammation levels. However, debates persist regarding the actual impact of exercise in the obese and overweight population.

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Perineural invasion (PNI) is an essential form of tumor metastasis in multiple malignant cancers, such as pancreatic cancer, prostate cancer, and head and neck cancer. Growing evidence has revealed that pancreatic cancer recurrence and neuropathic pain positively correlate with PNI. Therefore, targeting PNI is a proper strategy for pancreatic cancer treatment.

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Water in the nanometer to micrometer-sized pores of calcium silicate hydrate (C-S-H) is essential for the binding process of cementitious materials. The quantity, location, and physical state of water in C-S-H pores under extreme conditions significantly influence the strength and durability of cementitious materials. The present study employed ReaxFF and molecular dynamics (MD) simulation to evaluate the effects of water ultra-confined in the nanopores on the structure, bonds, dynamics, and tensile mechanism of the C-S-H grains at elevated temperatures.

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Aristolochic acid (AA), extracted from Aristolochiaceae plants, plays an essential role in traditional herbal medicines and is used for different diseases. However, AA has been found to be nephrotoxic and is known to cause aristolochic acid nephropathy (AAN). AA-induced acute kidney injury (AKI) is a syndrome in AAN with a high morbidity that manifests mitochondrial damage as a key part of its pathological progression.

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A better understanding of tumor metastasis is urgently required for the treatment and prognosis of hepatocarcinoma patients. Current work contributes a novel ceRNA feedback regulation pathway composed of epiregulin (EREG), microRNA-330-3p (miR-330-3p) and long non-coding RNA 021545 (lncRNA021545) in regulating hepatocarcinoma malignancy via epithelial-mesenchymal transition (EMT) process. Closely correlated, the deficiencies of EREG and lncRNA021545 and the overexpression of miR-330-3p were involved in the clinical progression of hepatocarcinoma.

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Vascular remodeling due to hypertension is one of the major health challenges facing countries around the world. Neohesperidin, a flavonoid glycoside found in citrus fruits, is an antioxidant. Neohesperidin has been studied for a variety of diseases in addition to hypertension.

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Article Synopsis
  • Hepatocellular carcinoma (HCC) is a major global health issue, ranking as the sixth most common cancer with high mortality rates, and microRNAs, particularly miR-4521, are crucial in understanding its development and progression.
  • This study focuses on the relationship between miR-4521 and the protein FAM129A in HCC, discovering that FAM129A is overexpressed in HCC tissues and correlates with increased markers for cancer progression (MMP9) and decreased inhibitors (TIMP-1).
  • Results show that enhancing miR-4521 while silencing FAM129A reduces HCC cell migration, invasion, and proliferation by triggering cell death pathways, highlighting the potential of targeting this regulatory
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In mouse models, the recovery of liver volume is mainly mediated by the proliferation of hepatocytes after partial hepatectomy that is commonly accompanied with ischemia-reperfusion. The identification of differently expressed genes in liver following partial hepatectomy benefits the better understanding of the molecular mechanisms during liver regeneration (LR) with appliable clinical significance. Briefly, studying different gene expression patterns in liver tissues collected from the mice group that survived through extensive hepatectomy will be of huge critical importance in LR than those collected from the mice group that survived through appropriate hepatectomy.

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Article Synopsis
  • Annexin A3 (ANXA3) has two isoforms, with the role of the 33-kDa isoform in cancer, specifically hepatocarcinoma, being the focus of this study.
  • The research found that 33-kDa ANXA3 is significantly upregulated in tumor tissues and contributes to cancer cell growth, metastasis, apoptosis, and drug resistance through various molecular pathways.
  • The study concluded that targeting 33-kDa ANXA3 could be a potential therapeutic approach for managing hepatocarcinoma, as its knockdown led to reduced tumor malignancy and growth in experiments.
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Background: Tumor metastasis is one of the main causes of the high mortality of hepatocellular carcinoma (HCC). E-Twenty Six variant gene 6 (ETV6) is a strong transcriptional repressor, associated with the development and progression of tumors. However, the exact role and underlying mechanism of ETV6 in HCC remain unclear.

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Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), a long non-coding RNA transcribed from the antisense strand of protein coding gene AFAP1, has attracted attention in cancer research. Despite, its biological function and regulatory mechanism in hepatocellular carcinoma still unknown. The present study revealed AFAP1-AS1 mediated hepatocarcinoma progression through targeting CRKL.

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Pulmonary complications frequently occur after liver transplantation and are often life-threatening. Thus, we investigated whether hepatic ischemic preconditioning (IP) attenuates acute lung injury (ALI) after small-for-size liver transplantation. Rat livers were explanted after 9-min ischemia plus 5-min reperfusion, reduced to 50% of original size , and implanted into recipients with approximately twice the donor body weight, resulting in quarter-size liver grafts (QSG).

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Objectives: The goal of this research was to develop a mouse orthotopic liver transplantation (LTx) model from donor-after-cardiac-death (DCD) grafts.

Materials And Methods: Mice were randomly assigned to the experimental group or the sham group. The mice in the experimental group were divided into three groups according to the warm ischemia time (WIT) of liver graft: normal LTx, WIT 30 minute (min) +LTx and WIT 45 min +LTx.

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Permeant cGMP analogs prevent the mitochondria permeability transition (MPT) . In this study, we explored whether 8-pCPT-cGMP prevents the MPT and decreases post-transplant damage to fatty partial liver grafts (FPG) . Rats were fed a control or high-fat, high-fructose diet for 2-week.

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Objective: Annexin A5 (Anxa5) is associated with the progression of some cancers, while its role and regulation mechanism in tumor lymphatic metastasis is rarely reported. This study aims to investigate the influence of Anxa5 knockdown on the malignant behaviours of murine hepatocarcinoma Hca-F cell line with high lymph node metastatic (LNM) potential and the underlying regulation mechanism.

Methods: RNA interfering was performed to silence Anxa5 in Hca-F.

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Oxidative stress plays an essential role in liver fibrosis. This study investigated whether MitoQ, an orally active mitochondrial antioxidant, decreases liver fibrosis. Mice were injected with corn oil or carbon tetrachloride (CCl4, 1:3 dilution in corn oil; 1 µl/g, ip) once every 3 days for up to 6 weeks.

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Article Synopsis
  • Growing teratoma syndrome (GTS), first noted in 1982, is a rare condition primarily affecting adolescents, and in this case, an adolescent girl underwent surgery for an immature teratoma in her ovary, followed by chemotherapy.
  • Nine years later, a giant mass was discovered, diagnosed as a mature teratoma, leading to the identification of ovarian GTS.
  • Analysis of 101 documented GTS cases indicated a median diagnosis age of 22, with right ovary involvement more common, and highlighted the need for complete surgical resection as the best treatment due to possible recurrence and insensitivity to chemotherapy, while also suggesting fertility-sparing options for young women.
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Article Synopsis
  • The Nogo-B receptor (NgBR) is a receptor that plays a role in breast cancer metastasis by promoting epithelial mesenchymal transition (EMT).
  • Increased NgBR expression has been linked to greater resistance to chemotherapy in a specific 5-FU resistant liver cancer cell line.
  • Targeting NgBR could potentially enhance the effectiveness of chemotherapy treatments like 5-FU for patients with hepatocellular carcinoma (HCC), particularly those with poor prognoses.
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Background: Suppressed mitochondrial biogenesis (MB) contributes to acute kidney injury (AKI) after many insults. AKI occurs frequently after liver transplantation (LT) and increases mortality. This study investigated whether disrupted mitochondrial homeostasis plays a role in AKI after LT.

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Background: The mouse model of arterialized orthotopic liver transplantation (AOLT) has played an important role in biomedical research. The available methods of sutured anastomosis for reconstruction of the hepatic artery are complicated, resulting in a high incidence of complications and failure. Therefore, we developed and evaluated a new model of AOLT in mice.

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Article Synopsis
  • Mixed acinar-endocrine carcinoma (MAEC) of the pancreas is a rare cancer, as highlighted by a case study of a 65-year-old Chinese female who presented with jaundice and abdominal pain.
  • Imaging revealed a significant pancreatic mass and liver lesions, leading to surgical intervention (Whipple operation and partial liver resection).
  • The patient's recovery was smooth, and after 12 months, there were no signs of cancer recurrence, indicating that early detection and complete removal of the tumor may improve outcomes, despite the generally poor prognosis for MAEC.
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