Publications by authors named "Qin-Yue Zheng"
Article Synopsis
- The study discusses the challenges in detecting N-acetylneuraminic acid (SA) and sialylated glycoproteins in biological samples, which are linked to diseases like cancer.
- A dual-capture system using molecular imprinting and post-imprinting modifications (PIM) was developed to enhance the binding efficiency and specificity of SA capture.
- The new magnetic polymers (Mag-MIPs-PIM) showed high specificity for both SA and sialylated glycoproteins, achieving a low detection limit and proving effective in human serum analysis.
A novel molecular-imprinted polymer (MIP)-based enzyme-free biosensor was created for the selective detection of glycoprotein transferrin (Trf). For this purpose, MIP-based biosensor for Trf was prepared by electrochemical co-polymerization of novel hybrid monomers 3-aminophenylboronic acid (M-APBA) and pyrrole on a glassy carbon electrode (GCE) modified with carboxylated multi-walled carbon nanotubes (cMWCNTs). Hybrid epitopes of Trf (C-terminal fragment and glycan) have been selected as templates.
View Article and Find Full Text PDFAim: To investigate the influence of esculentoside A (EsA) on immunological function and its mechanism of anti-inflammation.
Methods: Interleukin-1 production was measured by thymocyte co-stimulating assay; the radioactivity of [(3)H]arachidonic acid (AA) was used to evaluate the release of AA; prostaglandin E2 production was measured with radioimmunoassay (RIA); IL-2 and IFN-gamma were detected by ELISA method.
Results: EsA (3-12 micromol/L)could potently inhibit the production of IL-1 and PGE(2) from both silent and LPS induced macrophages.
Aim: To investigate the anti-inflammatory mechanism of esculentoside A (EsA) and to observe the effects of EsA on cellular adhesion between human umbilical vein endothelial cell (VEC304) and human neutrophil and to further observe the mRNA expression of intercellular adhesion molecule-1 (ICAM-1) and cluster of differentiation 18(CD18).
Methods: The hemocyte counting method was used for assaying the adhesion rate between VEC304 and neutrophil. The RT-PCR method was used for measuring the mRNA expression of ICAM-1 and CD18.
Aim: To investigate the influence of esculentoside A (EsA) on autoimmunity in mice and its possible mechanisms.
Methods: The level of anti-ds DNA antibody, proliferation of lymphoid cells, and inflammation by pathologic section of joint in mice were examined. The autoimmunity model is made through immunizing mice with formaldehyde treated Campylobacter jejuni strain CJ-S131 and Freund's complete adjuvant.