Diabetic kidney disease is an important microvascular complication of diabetes and the leading cause of end-stage renal disease. Its pathological characteristics mainly include epithelial mesenchymal transition(EMT) in glomerulus, podocyte apoptosis and autophagy, and damage of glomerular filtration barrier. Transforming growth factor-β(TGF-β)/Smad signaling pathway is specifically regulated by a variety of mechanisms, and is a classic pathway involved in physiological activities such as apoptosis, proliferation and differentiation.
View Article and Find Full Text PDFGraphitic carbon nitride (g-CN) has aroused broad interest in the field of photocatalysis and luminescence as a kind of metal-free semiconductor with a suitable band gap of ∼2.7 eV. The properties largely depend on the polymerization degree of g-CN.
View Article and Find Full Text PDFCsPbX (X = Cl, Br, I) perovskite quantum dots (QDs) have emerged as competitive candidate luminescent materials in the photoelectric fields due to their superior luminescence properties. However, the major drawback such as poor resistance to temperature, moisture, and irradiation of light, especially for the red QDs with I, hinders their practical applications. Herein, we synthesized Mn-doped CsPbCl embedded in the cage of zeolite-Y as a new orange-red phosphor for the white light-emitting diode (WLED).
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2018
With unique and efficient narrow-band red emission and broadband blue light absorption characteristics, Mn-activated fluoride red phosphors have gained increasing attention in warm white LEDs (WLEDs) and liquid crystal display (LCD) backlighting applications, whereas the intrinsic hygroscopic nature of these phosphors have inevitably limited their practical applications. Herein, a waterproof narrow-band fluoride phosphor KTiF:Mn (KTF) has been demonstrated via a facile superhydrophobic surface-modification strategy. With the use of superhydrophobic surface modification with octadecyltrimethoxysilane (ODTMS) on KTF surfaces, the moisture-resistance performance and thermal stability of the phosphor KTF can be significantly improved.
View Article and Find Full Text PDFUpconversion (UC) luminescence of lanthanide ions (Ln) has been extensively investigated for several decades and is a constant research hotspot owing to its fundamental significance and widespread applications. In contrast to the multiple and fixed UC emissions of Ln, transition metal (TM) ions, e.g.
View Article and Find Full Text PDFNitric oxide (NO) is an important mediator in cardiovascular system to regulate vascular tone and maintain tissue homeostasis. Its role in vascular cell regulation makes it promising to address the post-surgery restenosis problem. However, the application of NO is constrained by its high reactivity.
View Article and Find Full Text PDFGeometric cues have been used for a variety of cell regulation and tissue regenerative applications. While the function of geometric cues is being recognized, their stability and degradation behaviors are not well known. Here, we studied the influence of degradation on uniaxial-stretch-induced poly(ε-caprolactone) (UX-PCL) ridge/groove arrays and further cellular responses.
View Article and Find Full Text PDFAnisotropic geometries are critical for eliciting cell alignment to dictate tissue microarchitectures and biological functions. Current fabrication techniques are complex and utilize toxic solvents, hampering their applications for translational research. Here, we present a novel simple, solvent-free, and reproducible method via uniaxial stretching for incorporating anisotropic topographies on bioresorbable films with ambitions to realize stem cell alignment control.
View Article and Find Full Text PDF