Close functional coupling between Ca2+ release-activated Ca2+ channels and reactive oxygen species production in murine macrophages.

Aim: To investigate the role of Ca(2+) release-activated Ca(2+) (CRAC) channels in the ROS production in macrophages.

Methods: The intracellular [Ca(2+)](i) was analyzed by confocal laser microscopy. The production of ROS was assayed by flow cytometry.

Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in mice: the role of heme oxygenase-1.

Background: We hypothesized that posttreatment with 15-epi-16-parafluoro-phenoxy lipoxin A4 (ATL) could attenuate lipopolysaccharide (LPS)-induced acute lung injury in mice.

Methods: All the animals were randomly assigned to one of six groups (n = 6 per group). In the sham-vehicle group, mice were treated with 0.