Synthesis and bioactive evaluation of a novel series of coumarinazoles.

A series of novel coumarinazoles were designed, synthesized, and characterized by IR, NMR, MS and HRMS spectra. The bioactive assay for the newly prepared compounds against six bacteria and five fungi manifested that most new compounds exhibited good or even stronger antibacterial and antifungal activities in comparison with reference drugs Chloromycin, Norfloxacin and Fluconazole. Bis-azole alcohols 7a and 7d-e showed better anti-Candida utilis activity than mono-azole derivatives 4a and 4d-e at the tested concentrations, and they were more potent than the clinical Fluconazole.

catena-Poly[[trans-bis-(cyclo-hexane-1,2-diamine-κ²N,N)cadmium]-μ-iodido-(diiodidocadmium)-μ-iodido].

In the title compound, [Cd₂I₄(C₆H₁₄N₂)₂](n), there are two independent Cd(II) ions. One Cd(II) ion is coordinated in a slightly distorted octa-hedral coordination environment by four N atoms from two cyclo-hexane-1,2-diamine ligands and two iodido ligands. The other Cd(II) ion is coordinated by four iodido ligands in a slightly distorted tetra-hedral coordination environment.

N'(2),N'(5)-Bis[(E)-2-hy-droxy-benzyl-idene]-3,4-dimethyl-thio-phene-2,5-dicarbohydrazide.

In the title mol-ecule, C(22)H(20)N(4)O(4)S, both C=N bonds are in an E conformation. The benzene rings form dihedral angles of 12.10 (13) and 25.

(Z)-1-[4-Fluoro-2-(pyrrolidin-1-yl)phen-yl]-3-phenyl-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one.

In the title mol-ecule, C(21)H(19)FN(4)O, the triazole ring forms dihedral angles of 67.0 (1) and 59.6 (1)° with the phenyl and fluoro-substituted benzene rings, respectively.