Publications by authors named "Qin-Lei Fan"
Front Immunol
October 2020
Article Synopsis
- The human body hosts a complex community of microbes known as commensal microbiota, which plays a crucial role in influencing overall health and disease processes.
- Recent studies show that viral infections, a significant public health concern, interact closely with this microbiota, affecting both the body and the viruses.
- The balance of commensal microbiota can be disrupted by viruses, leading to dysbiosis, which may further impact viral infectivity and the host's health.
Article Synopsis
- - Organisms have developed mechanisms to protect their DNA, but damage can occur, necessitating DNA repair pathways, especially for double-strand breaks in eukaryotes like mammals.
- - There are two main repair pathways: nonhomologous DNA end joining, which can lead to errors, and homologous recombination, which is more precise but less efficient.
- - The text discusses strategies to enhance the efficiency of homologous directed repair by manipulating the cell cycle, boosting key proteins for homologous recombination, and choosing suitable donor DNA.
Article Synopsis
- Contagious pustular dermatitis is a zoonotic disease linked to the orf virus, causing major economic issues during pandemic outbreaks.
- A study tested blood samples from 628 healthy goats in China and found the orf virus present in some of them.
- The virus from these asymptomatic goats was shown to be infectious, causing typical symptoms in uninfected goats, indicating that healthy-looking animals can still carry the virus and contribute to the disease's spread.
