Calcium-Activated Chloride Channel A4 (CLCA4) Plays Inhibitory Roles in Invasion and Migration Through Suppressing Epithelial-Mesenchymal Transition via PI3K/AKT Signaling in Colorectal Cancer.

BACKGROUND Calcium-activated chloride channel A4 (CLCA4) is known as a tumor suppressor which contributes to the progression of a number of types of malignant tumors. However, little is known about the functional roles of CLCA4 in colorectal cancer (CRC). MATERIAL AND METHODS In this study, the expression patterns and dysregulation of mRNAs in CRC tissues were profiled by analyzing GSE21510 datasets from Gene Expression Omnibus database which contains 104 primary hepatocellular carcinoma tissues and 24 normal liver tissues, and by performing Kaplan-Meier analysis of TCGA data.

[Testbed-Based Exhaust Emission Factors for Marine Diesel Engines in China].

Water-borne transportation plays an important role in the economic and social development and contributes greatly to air pollution in China as well. An effective regulating policy is dependent on accurate estimation in terms of sorts, quantification and location of emissions. However, there is insufficient real and reliable data source for China's marine diesel engines and vessels.