Association between multimorbidity and having less than 20 natural teeth among Chinese older adults: a cross-sectional study.

Understanding the impact of multimorbidity on having less than 20 natural teeth is crucial for safeguarding the oral health of older adults with multimorbidity. This study aimed to analyze the association between multimorbidity and having less than 20 natural teeth in older Chinese adults. The data for this analysis were obtained from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), which covers 23 provinces, municipalities, and autonomous regions throughout China.

Mussel Foot Protein Membrane-Enclosed Crystalline Drug with Zero-Order Release Kinetics for Long-Acting Therapy.

Injectable formulations with sustained and steady release capabilities are critically required to treat diseases requiring temporary or lifelong continuous therapy, especially for drugs with a short half-life. Additionally, achieving a sufficiently high drug loading in a single dose remains a persistent challenge. Herein, by mimicking the formation principles of mussel adhesive plaques, we have developed membrane-enclosed crystalline systems of insulin and progesterone as model macro- and small-molecular crystalline drugs.

Chronic inflammation response as a key factor in polycystic ovary syndrome among patients with bipolar disorder.

Background: This study aimed to investigate serum inflammatory factor levels of polycystic ovary syndrome (PCOS) in female patients with bipolar disorder (BD) to explore the related inflammatory molecular mechanisms preliminarily.

Methods: The study recruited 72 female drug-naïve patients with BD and 98 female healthy controls (HCs). Demographic information, menstrual cycles, sex hormone levels, and ovarian ultrasound data were collected from them.

Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancers.

Genes involved in the regulation of chromatin structure are frequently disrupted in cancer, contributing to an aberrant transcriptome and phenotypic plasticity. Yet, therapeutics targeting mutant forms of chromatin-modifying enzymes have yielded only modest clinical utility, underscoring the difficulty of targeting the epigenomic underpinnings of aberrant gene regulatory networks. Here, we sought to identify novel epigenetic vulnerabilities in diffuse large B-cell lymphoma (DLBCL).

Positive charging effect in quantum-dot light-emitting diodes.

It is widely accepted that there are significantly more electrons than holes in ZnO-based quantum-dot light-emitting diodes (QLEDs) due to the outstanding electrical properties of the ZnO film. However, here we found that holes but not electrons are stored in the quantum dots (QDs) after turning off the driving voltage. This unexpected hole storage (positive charging) behavior is attributed to the strong confinement effect caused by the wide bandgap shell outside the QDs.

Ultrahigh piezoelectricity and temperature stability in piezoceramics by synergistic design.

Piezoceramics with both high piezoelectric properties and broad temperature usage range are highly in demand for sensor and actuator applications. Unfortunately, the trade-off relationship between two properties poses a significant challenge that remains unresolved. Herein, through combined phase boundary engineering and process engineering, we report the simultaneous achievements of substantially enhanced piezoelectric coefficient d (from 784 pC/N to 855 pC/N) and piezoelectric strain d* (from 620 pm/V to 860 pm/V), and ultrahigh temperature stability (i.

Light Weight Organic Composites with High Thermal Management Capability.

With the advancement of science and technology, effectively addressing the issue of heat dissipation in electronic equipment has become a key research topic. Polymers have attracted attention due to their low price, excellent flexibility, and lightweight characteristics, but thermal conductivity has a limitation. In this work, aiming for all-polymer composites with lightweight and high thermal conductivity, poly(p-phenylene benzobisoxazole) (PBO) fibers were used to construct a long-range ordered heat transfer path in the organosilicon matrix, and an all-organic composite material with a low density of 1.

Construct ZnSeTe/ZnTe Nanostructures with the Tunable Emission from 450 to 760 nm.

Developing heavy-metal-free materials with wide tunable emission is important to light-emitters. The alloying method is utilized in ZnSe magic size clusters (MSCs) with Te to form ZnSeTe and manipulate the band gap structure in ZnSe. The growth of ZnTe on alloyed ZnSeTe quantum dots (QDs) forms ZnSeTe/ZnTe core/shell nanostructures, showing the tunable photoluminescence emission peak from 450 to 760 nm with the different thicknesses of ZnTe shell.

Unraveling climate change-induced compound low-solar-low-wind extremes in China.

China's pursuit of carbon neutrality targets hinges on a profound shift towards low-carbon energy, primarily reliant on intermittent and variable, yet crucial, solar and wind power sources. In particular, low-solar-low-wind (LSLW) compound extremes present a critical yet largely ignored threat to the reliability of renewable electricity generation. While existing studies have largely evaluated the impacts of average climate-induced changes in renewable energy resources, comprehensive analyses of the compound extremes and, particularly, the underpinning dynamic mechanisms remain scarce.

Endothelial-secreted Endocan activates PDGFRA and regulates vascularity and spatial phenotype in glioblastoma.

Extensive neovascularization is a hallmark of glioblastoma (GBM). In addition to supplying oxygen and nutrients, vascular endothelial cells provide trophic support to GBM cells via paracrine signaling. Here we report that Endocan (ESM1), an endothelial-secreted proteoglycan, confers enhanced proliferative, migratory, and angiogenic properties to GBM cells and regulates their spatial identity.

Evaluation of Hypoglycemic Polyphenolic Compounds in Blueberry Extract: Functional Effects and Mechanisms.

Blueberries are rich in polyphenols, which exhibit significant anti-diabetic activity. In this study, polyphenolic compounds with potential hypoglycemic activity were identified from blueberry polyphenol extract (BPE). This research focused on assessing the hypoglycemic effects of BPE and its polyphenolic compounds (dihydroquercetin and gallic acid) on diabetic mice induced by streptozotocin (STZ) and high-fat diet (HFD), as well as the related fundamental mechanisms.

Tantalum-stabilized ruthenium oxide electrocatalysts for industrial water electrolysis.

The iridium oxide (IrO) catalyst for the oxygen evolution reaction used industrially (in proton exchange membrane water electrolyzers) is scarce and costly. Although ruthenium oxide (RuO) is a promising alternative, its poor stability has hindered practical application. We used well-defined extended surface models to identify that RuO undergoes structure-dependent corrosion that causes Ru dissolution.

Core-Shell Magnetic Particles: Tailored Synthesis and Applications.

Core-shell magnetic particles consisting of magnetic core and functional shells have aroused widespread attention in multidisciplinary fields spanning chemistry, materials science, physics, biomedicine, and bioengineering due to their distinctive magnetic properties, tunable interface features, and elaborately designed compositions. In recent decades, various surface engineering strategies have been developed to endow them desired properties (e.g.

The 2023 report of the synergetic roadmap on carbon neutrality and clean air for China: Carbon reduction, pollution mitigation, greening, and growth.

The response to climate change and air pollution control demonstrates strong synergy across scientific mechanisms, targets, strategies, and governance systems. This report, based on a monitoring indicator system for coordinated governance of air pollution and climate change, employs an interdisciplinary approach combining natural and social sciences. It establishes 20 indicators across five key areas: air pollution and climate change, governance systems and practices, structural transformation and technologies, atmospheric components and emission reduction pathways, and health impacts and co-benefits.

[Historical evolution and modern research on co-production and processing method of "solid-liquid excipients"].

"Solid-liquid excipients" co-production is one of the typical processing methods of excipients used from ancient times to the present day, and is widely applied in various processing schools and regional specialty varieties. This method significantly reduces the toxicity of traditional Chinese medicine(TCM), moderates medicinal properties, and enhances clinical efficacy. However, modern scientific research has given it limited attention, and many co-production methods of "solid-liquid excipients" have not been applied in production and practice.

Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening.

Stimulator of interferon genes (STING) traffics across intracellular compartments to trigger innate responses. Mutations in factors regulating this process lead to inflammatory disorders. To systematically identify factors involved in STING trafficking, we performed a genome-wide optical pooled screen (OPS).

Pulsed radiofrequency alleviates neuropathic pain by upregulating MG53 to inhibit microglial activation.

Background: Patients with neuropathic pain (NP) have significantly lower quality of life. Because the pathophysiology of NP is not fully understood, there is a lack of effective treatment for it in clinic. This study set out to investigate the precise mechanism by which pulsed radiofrequency (PRF) alleviated NP.

Ultrafast Intelligent Sensor for Integrated Biological Fluorescence Imaging and Recognition.

Fluorescence imaging and recognition are core technologies in targeted medicine, pathological surgery, and biomedicine. However, current imaging and recognition systems are separate, requiring repeated data transfers for imaging and recognition that lead to delays and inefficiency, hindering the capture of rapidly changing physiological processes and biological phenomena. To address these problems, we propose an integrated intelligent sensor for biological fluorescence imaging and ultrafast recognition.

pH-responsive hydrogel with gambogic acid and calcium nanowires for promoting mitochondrial apoptosis in osteosarcoma.

Calcium (Ca) overload therapy gained significant attention in oncology. However, its therapeutic efficacy remained limited due to insufficient Ca accumulation at the tumor site and suboptimal intracellular Ca influx. In this study, gambogic acid (GA), a natural phenolic compound known to promote Ca influx, was encapsulated within an enzyme-triggered, pH-responsive hydrogel (GM@Lip@CHP-Gel) containing Ca hydrogen phosphate nanowires (CHP) to achieve a synergistic approach for bone tumor therapy.

Narrowband absorption far-red organic photodetector for photoplethysmography.

Narrowband absorption organic semiconductors are highly attractive for spectrally selective photodetection applications requiring lightweight and customizable devices. Although narrowband absorption photodetectors have achieved success in the visible range, far-red (650-750 nm) devices are scarce. The far-red wavelength range is relevant for applications in medical diagnostics, such as photoplethysmography for blood oxygen saturation detection.

Improved alternate wetting and drying irrigation increases global water productivity.

Rice is the staple food for half of the world's population but also has the largest water footprint among cereal crops. Alternate wetting and drying (AWD) is a promising irrigation strategy to improve paddy rice's water productivity-defined as the ratio of rice yield to irrigation water use. However, its global adoption has been limited due to concerns about potential yield losses and uncertainties regarding water productivity improvements.

A high-speed infrared tellurium photodetector on a silicon nitride platform.

The hybrid integration of two-dimensional (2D) materials on various photonic integration platforms has attracted widespread research interest because of the new functionalities enabled by the 2D materials for applications in photodetection, optical modulation and nonlinear optical signal processing. Tellurium is known to have high mobility, and quasi-2D tellurium is stable in air and has a small bandgap that may make it suitable for platform-independent scalable integration of high-performance photodetectors in the infrared band. In this work, we propose and implement a new structure for integrating tellurium with silicon nitride (SiN) waveguides, adding photodetector capability to an otherwise passive waveguide platform.

Plausible Colloidal Methods to Synthesize Semiconductor Nanowires: Deep Study From ZnSe Nanorods.

When the diameter of semiconductor nanowires is below the Bohr radius, confined excitons in the radial direction can freely move along the elongated axis direction, highlighting their potential for applications in quantum information and optoelectronic devices. Controlled anisotropic growth and oriented attachment are viable strategies for producing ultra-long semiconductor nanowires with precisely controlled lengths and diameters. Anisotropic ZnSe nanorods are used as the initial seeds for the controlled anisotropic growth and oriented attachment methods.