Tuning Transition Metal 3d Spin state on Single-atom Catalysts for Selective Electrochemical CO Reduction.

Tuning transition metal spin states potentially offers a powerful means to control electrocatalyst activity. However, implementing such a strategy in electrochemical CO reduction (COR) is challenging since rational design rules have yet to be elucidated. Here we show how the addition of P dopants to a ferromagnetic element (Fe, Co, and Ni) single-atom catalyst (SAC) can shift its spin state.

Electricity-Efficient On-Demand Photothermal Activation for Tunable Thermochromic Windows.

Thermochromic (TC) windows with passively controlled sunlight regulation have demonstrated significant building energy conservations. Realizing the active control of the TC window can expand its popularity while remaining an intractable challenge. Herein, a low-power-dissipative strategy that endows TC windows with an actively tunable transmittance is presented through the electro-induced tunable photothermal conversions (ETPCs).

Primary gingival diffuse large B‑cell lymphoma with muscle invasion: A case report.

Primary gingival diffuse large B-cell lymphoma (DLBCL) with muscle invasion is rare and accounts for ~0.5% of all reported cases of extranodal lymphoma. The present study describes the case of a 49-year-old man that initially presented at Yingshan County People's Hospital (Nanchong, China) in August 2017 with a chief complaint of tenderness and swelling of the jaw.

Structural evaluation and formation regularities of garlic clove-like meat in prefabricated grass carp.

Moderately marinated fish meat forms a garlic clove-like structure after cooking. However, this structure's formation mechanism and influencing factors are unclear. Therefore, this study explored the changes in protein components and potential protein markers during the formation of garlic clove-like structure.

Channels and Transporters in Ischemic Brain Edema.

Brain edema is one of the most devastating consequences of acute ischemic stroke, but an effective and preventive therapy targeting the formation of ischemic brain edema has not yet to be validated. Ischemic brain edema is primarily caused by damage to the blood-brain-barrier, leading to the leakage of ions and water into the brain tissue. Ion channels and transporters play a crucial role in ischemic brain edema.

Different types of cell death and their interactions in myocardial ischemia-reperfusion injury.

Myocardial ischemia-reperfusion (I/R) injury is a multifaceted process observed in patients with coronary artery disease when blood flow is restored to the heart tissue following ischemia-induced damage. Cardiomyocyte cell death, particularly through apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis, is pivotal in myocardial I/R injury. Preventing cell death during the process of I/R is vital for improving ischemic cardiomyopathy.

Lysine 2-hydroxyisobutyrylation of HXK1 alters energy metabolism and K channel function in the atrium from patients with atrial fibrillation.

Background: Atrial fibrillation (AF) is the most common form of arrhythmia and is a growing clinical problem. Post-translational modifications (PTMs) constitute crucial epigenetic mechanisms but modification of lysine 2-hydroxyisobutyrylation (K) in AF is still unknown. This study aimed to investigate the role and mechanism of K in AF.

Gut-X axis.

Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, including the liver, heart, brain, lungs, kidneys, bone, skin, reproductive, and endocrine systems. In this review, we applied the "gut-X axis" concept to describe the linkages between the gut and other organs and discussed the latest findings related to the "gut-X axis," including the underlying modulatory mechanisms and potential clinical intervention strategies.

End Group-Induced Ultrafast Exciton Dissociation of Supramolecular Perylene Monoimide Nanoribbons for Efficient Photocatalytic Hydrogen Evolution.

Achieving fast exciton dissociation is a critical factor for optimizing the performance of organic photocatalysts in solar energy conversion. This work demonstrates the end-group-dependent ultrafast exciton dissociation in supramolecular perylene monoimide (PMI) nanostructures. A series of PMI molecules are designed by connecting the amide site with methylene carboxyl (─CH─COOH), methylene phosphonic acid (─CH─POH), and methylene sulfonic acid (─CH─SOH) to increase the dipole moment and built-in electric field, thereby effectively diminishing exciton binding energy.

Surgical treatment of infectious severe calcaneal bone defects in children by the Ilizarov technique.

Introduction: The soft tissue of the heel is weak, and calcaneal bone defects occur easily post-infection, resulting in the inability of paediatric patients to walk normally. Calcaneal reconstruction is challenging. We aimed to evaluate the methodology and clinical effects of the Ilizarov technique in the treatment of calcaneal infectious bone defects.

Single-molecule measurements of bacteriophage lambda DNA packaging using purified terminase motor proteins and E. coli integration host factor.

Biomotor-driven DNA packaging is a key step in the life cycle of many viruses. We previously developed single-molecule methods using optical tweezers to measure packaging dynamics of the bacteriophage lambda motor. The lambda system is more complex than others examined via single-molecule assays with respect to the packaging substrate and ancillary proteins required.

Fast and stable NH storage in multielectron H-bonding-acceptor organic molecules for aqueous zinc batteries.

High-capacity small organic compounds are easily dissolved in aqueous electrolytes, resulting in limited cycling stability of Zn-organic batteries (ZOBs). To address this issue, we proposed constructing superstable lock-and-key hydrogen-bonding networks between the 2,7-dinitrophenanthraquinone (DNPQ) cathode and NH charge carriers to achieve ultrastable ZOBs. DNPQ, with its sextuple-active carbonyl/nitro motifs (H-bonding acceptors), was found to be uniquely prone to redox-coupling with tetrahedral NH ions (H-bonding donors) while excluding sluggish Zn ions, owing to a lower activation energy (0.

Contributing role and molecular basis of Vitamin D/Vitamin D receptor deficiency in hyperhomocysteinemia-induced cardiac hypertrophy.

Hyperhomocysteinemia and vitamin D deficiency are known to promote cardiac hypertrophy, however, whether vitamin D signaling is involved in hyperhomocysteinemia-induced cardiac hypertrophy remains unexplored. This study aimed to address this question by clarifying the effect of homocysteine on vitamin D and vitamin D receptor (VDR), with further elucidation of the regulatory mechanisms. Methionine diet-induced hyperhomocysteinemic (HHcy) rats and homocysteine-incubated cardiomyocytes were used as in vivo and in vitro models of cardiac hypertrophy.

Effects of virtual reality technology on early mobility in critically ill adult patients: a systematic review and meta-analysis.

Objective: The study aimed to explore the effects of virtual reality (VR) technology on motor function rehabilitation in critically ill patients.

Methods: Adhering to the PRISMA systematic evaluation method for developing the literature ranking criteria and search strategy, the following databases were systematically searched: PubMed, Embase, Web of Science, the Cochrane Library, CNKI, Wanfang Data, Chinese Medical Journal Full-Text Database, and SINOMED. The search focused on the impact of virtual reality technology on limb function rehabilitation in critically ill patients, covering the period from the database's inception to 6 December 2024.

Vagus nerve stimulation inhibits PANoptosis and promotes neurofunctional recovery of cerebral ischemic stroke in a Sirt1-dependent manner.

Vagus nerve stimulation (VNS) can promote neurofunctional recovery following cerebral ischemic stroke (CIS), but the underlying mechanism remains unclear. PANoptosis, a novel form of inflammatory programmed cell death, may play a role in the progression of CIS. Our previous studies have indicated that Sirt1 exerts neuroprotection against CIS by modulating various programmed cell death pathways.

The analysis of factors influencing patient choice of healthcare providers between tertiary hospitals and community clinics.

Background: The uneven distribution of medical resources in China has led to persistently low utilization rates of primary healthcare institutions. The tiered healthcare delivery system aims to optimize resource allocation and strengthen primary care, yet patient preferences for tertiary hospitals hinder its effective implementation. Understanding the factors influencing healthcare-seeking behaviors is crucial for improving policies and promoting system efficiency.

Esketamine reduces postoperative depression in breast cancer through TREK-1 channel inhibition and neurotransmitter modulation.

Postoperative depression significantly affects the quality of life of breast cancer patients. This study explores the potential therapeutic effects of esketamine on postoperative depression through modulation of the TREK-1 two-pore domain potassium channel. We analyzed data from 54 female breast cancer patients who underwent surgery at our hospital between 2019 and 2023, dividing them into experimental and control groups based on esketamine treatment.

Enhancement Effect of Low-Frequency Raman Modes in Graphene Nanoscrolls.

Graphene nanoscrolls (GNSs) are unique structures with interlayer coupling modes distinct from those in graphene and carbon nanotubes, exhibiting potential physical properties yet to be explored. Here we investigated the low-frequency Raman modes in GNSs formed from 1 to 3 layer graphene (1-3LG). The results of the Raman spectroscopy show that both shear (C) and layer breathing (LB) modes have appeared in monolayer graphene nanoscrolls (1L-GNSs), although these modes never exist in the flat 1LG.

A case report of successful treatment of advanced thymic squamous cell carcinoma with poor performance status using multimodal therapy.

Thymic squamous cell carcinoma (TSCC) is a rare yet aggressive tumor associated with a dismal prognosis. The patient, a 76-year-old male, presented with symptoms of fatigue, bloody sputum and dyspnea. Computed tomography (CT) and positron emission tomography/computed tomography (PET/CT) scans demonstrated a significant mass in the chest, accompanied by metastasis to adjacent lymph nodes.

Effects of extended working lives on depressive symptoms, physical, and cognitive health in middle and later life: Evidence from China.

Introduction: Many countries are extending working lives to counteract the shrinking labor force caused by population aging. However, the health implications of this approach for middle-aged and older adults remain unclear, particularly in low- and middle-income countries.

Methods: Data were drawn from the 2011-2020 China Health and Retirement Longitudinal Study to analyze the effect of labor force participation on multidimensional health, with a focus on activities of daily living disability, depressive symptoms, and cognitive impairment.

Study on lean production management of new energy vehicle body painting based on the dual perspectives of digital transformation and VSM.

The automobile body painting production system exists in the backward management concept of focusing on production and ignoring environmental protection, focusing on traditional technology and unwilling to innovate, etc., high production cost and environmental protection standards, which have had a negative impact on the industry's long-term growth. Based on the value stream mapping (VSM) analysis technology, the current situation of the value stream of the body spraying process of TJ Automobile Manufacturing Company is analyzed, the problem of waste in the production process of automobile body painting system affected by Eliminate Combine Rearrange Simplify (ECRS)a four-step problem-solving technique was studied and analyzed, a new method for the application of value stream graph analysis technology in the digital transformation environment is proposed, and a suitable production improvement scheme for the body painting system is formulated by using the new method, which increases the value-added operation time of the painting production process by 9.

Crystal Morphological Engineering of MFI Nanosheet Assisted by Pyrrolidone Compounds.

Nanosheet MFI zeolite with a shortened -axis length is highly desirable for industrial applications due to the predominant mass transfer pathway provided by its larger straight channels along the -axis. The introduction of specific additives into the precursor fluid of the zeolite can facilitate crystal anisotropic growth. However, the range of available additives is limited, and their role and underlying mechanisms remain poorly understood.

Effects of proteolysis pretreatment on the formation, structural changes and emulsifying properties of rice glutelin amyloid-like fibrils.

Enzymatic hydrolysis prior to fibrillation can improve the formation capacity of food protein fibrils, which further affects their functional properties. In this study, the effects of proteolysis pretreatment with trypsin on the formation, structural changes and emulsifying properties of rice glutelin (RG) fibrils were investigated. The results showed that the formation of protein fibrils was confirmed by Thioflavin T fluorescence spectra, and the fibril formation capacity was enhanced by trypsin proteolysis pretreatment.

Dysregulation of G6PD by HPV E6 exacerbates cervical cancer by activating the STAT3/PLOD2 pathway.

High-risk human papillomavirus (HPV) infection is strongly linked to the initiation and progression of cervical cancer, yet the precise molecular mechanisms involved remain partially understood. This investigation examined differential protein expression profiles in various cohorts, including healthy controls and HPV-positive cervical cancer patients with different expression levels of glucose-6-phosphate dehydrogenase (G6PD), shedding light on the dysregulation of oncogenic proteins by HPV. Proteomic analysis of cervical tissues revealed specific protein signatures, indicating significant upregulation of HPV E6, G6PD, STAT3, phosphorylated STAT3, and procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2) in HPV-infected cervical cancer tissues and cell lines.