[Lenthening and reconstruction progress of achondroplastic short arm deformity].

Objective: To describe the characteristics of short arm deformity in patients with achondroplasia, and summarize the progress of its lenthening and reconstruction, so as to provide reference for clinical diagnosis and treatment.

Methods: The literature on the lenthening of upper limb with achondroplastic short arm deformity at home and abroad in recent years was reviewed, and the characteristics, extension methods, postoperative management, effectiveness evaluation, and related complications of short arm deformity were summarized.

Results: Achondroplastic short arm deformity affect the patient's daily perineal hygiene activities.

Impact of glioma metabolism-related gene ALPK1 on tumor immune heterogeneity and the regulation of the TGF-β pathway.

Background: Recent years have seen persistently poor prognoses for glioma patients. Therefore, exploring the molecular subtyping of gliomas, identifying novel prognostic biomarkers, and understanding the characteristics of their immune microenvironments are crucial for improving treatment strategies and patient outcomes.

Methods: We integrated glioma datasets from multiple sources, employing Non-negative Matrix Factorization (NMF) to cluster samples and filter for differentially expressed metabolic genes.

Characterization of feeding damage by tea mosquito bug, Waterhouse (Hemiptera: Miridae) on Hainan Dayezhong tea cultivar.

The tea mosquito bug, Waterhouse (Hemiptera: Miridae), is a devastating piercing-sucking pest in tropical tea plantations. The Hainan Dayezhong (HNDYZ) is a large-leaf tea cultivar widely cultivated around the Hainan tea region in South China. However, information regarding the feeding damage of on the HNDYZ tea plant remains scarce.

Effects of rosemary extract and its residue on production, immune performance, and gut microbiota in geese.

Introduction: To explore the effects of rosemary extract (RE) and its residue (RR) on the production, immune performance, and gut microbiota of geese.

Methods: We treat 28-day-old Sichuan white geese ( = 180) with three diets: (1) basal diet (control), (2) basal diet supplemented with 0.02% RE, and (3) basal diet supplemented with 15% RR for 42 days.

Multi-dimensional bio mass cytometry: simultaneous analysis of cytoplasmic proteins and metabolites on single cells.

Single-cell multi-dimensional analysis enables more profound biological insight, providing a comprehensive understanding of cell physiological processes. Due to limited cellular contents, the lack of protein and metabolite amplification ability, and the complex cytoplasmic environment, the simultaneous analysis of intracellular proteins and metabolites remains challenging. Herein, we proposed a multi-dimensional bio mass cytometry platform characterized by protein signal conversion and amplification through an orthogonal exogenous enzymatic reaction.

Halogen-Bearing Peptide Liquid Crystals to Elicit Molecular Alignments for Residual Dipolar Coupling Measurement.

Residual dipolar coupling (RDC) not only contributes to the dynamic analysis of proteins but also provides a robust route for the structure determination of small organic compounds. An essential prerequisite for this methodology is the availability of alignment media. Herein, a series of novel peptide-based alignment media are generated by introducing D-type or halogen-bearing amino acids for RDC measurements.

The effect of blood glucose levels on serum triglyceride clearance in patients with hyperlipidemic acute pancreatitis.

Preventing moderately severe and severe acute pancreatitis (MSAP & SAP) is the primary goal of the management of hyperlipidemic acute pancreatitis (HLAP). The main aim of this study was to investigate the factors affecting serum triglyceride (TG) clearance, particularly blood glucose (GLU) levels, which could potentially help to prevent the development of MSAP & SAP. The clinical data from 177 patients with MSAP & SAP and 195 patients with mild acute pancreatitis (MAP) on days 1-6 after the onset were collected and analyzed by multivariate logistic regression to identify the factors that have an impact on the severity of HLAP, especially TG.

Role of metabolic characteristics in the co-occurrence of insomnia, Alzheimer's disease, and Parkinson's disease: a Mendelian randomization study.

Objective: There reportedly exists a significant comorbidity between insomnia and neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), indicative of a potential link to serum metabolic dysregulation.

Method: To elucidate shared pathophysiological mechanisms between insomnia and AD/PD, we performed comprehensive two-sample Mendelian randomization (MR) analyses, investigating 1,400 serum metabolic characteristics for their causal relationships with the risks of insomnia, AD, widely defined AD (WDAD), and PD. We employed publicly available genetic data; the primary estimate was determined using inverse-variance weighting, supplemented by weighted median, simple mode, weighted mode, and the MR-PRESSO and MR-Egger methods to evaluate heterogeneity and pleiotropy.

Fractionated radiotherapy initiated at the early stage of bone metastasis is effective to prolong survival in mouse model.

Background And Purpose: Bone metastasis is common for breast cancer and associated with poor prognosis. Currently, radiotherapy (RT) serves as the standard treatment for patients exhibiting symptoms of bone metastasis to alleviate pain. Whether earlier application of RT will better control bone metastasis remains unclear.

Endoscopic ultrasonography-based intratumoral and peritumoral machine learning ultrasomics model for predicting the pathological grading of pancreatic neuroendocrine tumors.

Objectives: The objective is to develop and validate intratumoral and peritumoral ultrasomics models utilizing endoscopic ultrasonography (EUS) to predict pathological grading in pancreatic neuroendocrine tumors (PNETs).

Methods: Eighty-one patients, including 51 with grade 1 PNETs and 30 with grade 2/3 PNETs, were included in this retrospective study after confirmation through pathological examination. The patients were randomly allocated to the training or test group in a 6:4 ratio.

Polarized pectin accumulation regulates differential hypocotyl elongation at the dark-to-light transition.

As one of the most influential environmental factors, light fundamentally shapes plant physiology and growth traits. The hypocotyl is critical for the morphological establishment of the seedling, and its length displays remarkable plasticity upon perception of changes in the light conditions. Although remodeling of the primary cell walls is well-documented to play an important role in hypocotyl growth, how the hypocotyl elongation rate is swiftly repressed at the dark-to-light transition remains elusive.

Polybutylene succinate/lignin composites with tunable optical, mechanical, and thermal properties based on fractionation treatment.

The inherent heterogeneity, poor compatibility with polymers, and dark color of lignin limit its application in composites. In this study, original lignin (OL) was fractionated sequentially using four green organic solvents to obtain lignin fractions with different chemical structures. These well-defined lignin fractions were then blended with polybutylene succinate (PBS) to fabricate biocomposites.

Parent-child relationship and junior high academic performance: Differentiated impacts of fathers and mothers with self - efficacy as a mediator.

This study aimed to address the overlooked differences in the effects of father-child and mother-child relationships on junior high school students' academic performance. Utilizing data from the China Education Panel Survey, it explored these relationships' impacts on overall and subject-specific academic achievements and the mediating role of self-efficacy. Findings revealed both relationships had positive effects, with the mother-child relationship being more prominent.

IINS Vs CALLY Index: A Battle of Prognostic Value in NSCLC Patients Following Surgery.

Objective: This research sought to assess the predictive potential of the inflammation-immunity-nutrition score (IINS) and the high-sensitivity C-reactive protein-albumin-lymphocyte (CALLY) index in individuals with NSCLC post-surgery.

Methods: The study enrolled 506 patients with NSCLC undergoing R0 resection at the First Affiliated Hospital of Xi'an Jiaotong University. The training cohort was analyzed utilizing X-tile software to identify the ideal threshold values for categorizing high-sensitivity C-reactive protein, albumin, lymphocyte count, and the CALLY index.

Safety and efficacy of mecapegfilgrastim in preventing neutropenia in patients with head and neck cancer: a multicenter, prospective, observational, real-world study.

Background: Mecapegfilgrastim, a long-acting granulocyte colony-stimulating factor, is approved in China for neutropenia prevention. However, data on its safety and efficacy in patients with head and neck cancer remain limited. This study aimed to evaluate the safety and efficacy of mecapegfilgrastim in preventing neutropenia among these patients undergoing chemotherapy, particularly those receiving chemoradiotherapy or chemoimmunotherapy.

Long-term exposure to PM and its constituents and visual impairment in schoolchildren: A population-based survey in Guangdong province, China.

Background: Exposure to fine particulate matter (PM) has been linked to visual impairment. Nevertheless, evidence associating PM constituents with visual impairment in schoolchildren is sparse.

Objectives: To explore the effects of long-term exposure to PM and its constituents on visual impairment.

Complete genome sequence of GL-4.

A cellulase-producing was previously isolated from the intestinal tract of domestic bamboo rat and identified as GL-4. In this study, we present the complete genome sequence of GL-4. The genome is 4,271,214 bp long, with a guanine-cytosine content of 43.

Oral Administration of Hydrogen-rich Water: Biomedical Activities, Potential Mechanisms, and Clinical Applications.

Molecular hydrogen (H2) is considered a biological antioxidant. Hydrogen-rich Water (HRW) is regular water that contains dissolved H2 and has become more widely used in recent years. This review summarizes the basic research and clinical applications of HRW consumption to support its use for daily health and clinical treatment.

In-Plane Polarization-Triggered WS-Ferroelectric Heterostructured Synaptic Devices.

To date, various kinds of memristors have been proposed as artificial neurons and synapses for neuromorphic computing to overcome the so-called von Neumann bottleneck in conventional computing architectures. However, related working principles are mostly ascribed to randomly distributed conductive filaments or traps, which usually lead to high stochasticity and poor uniformity. In this work, a heterostructure with a two-dimensional WS monolayer and a ferroelectric PZT film were demonstrated for memristors and artificial synapses, triggered by in-plane ferroelectric polarization.

Understanding the phase structure evolution and charge storage mechanism of FeCoNi-MOFs as electrodes for asymmetric supercapacitors.

Metal-organic frameworks (MOFs) due to abundant apertures, adjustable components, and multi-purpose structures have broad application prospects in supercapacitors. However, its low conductivity, poor stability, and difficulty growing evenly on the conductive substrate limit the electrochemical energy storage performance. Herein, with FeCoNi-OH nanosheets serving as the precursors, the trimetallic FeCoNi-MOF (FCNM) multilayer structure is successfully synthesized on activated carbon cloth (AC), and its optimal growth state (FCNM/AC-12 h) is achieved by regulating the reaction time.

Bioinspired Electrostatic Capture-and-Release System for Precise Microdroplet Manipulation.

The application of physical fields is crucial for droplet generation and manipulation, underpinning technologies like printing, microfluidic biochips, drug delivery, and flexible sensors. Despite advancements, precise micro/nanoscale droplet generation and accurate microfluidic reactions remain challenging. Inspired by the liquid ejection mechanisms in microscopic organisms, an electrostatic manipulator for the precise capture, emission, and transport of microdroplets is proposed.

MHCI trafficking signal-based mRNA vaccines strengthening immune protection against RNA viruses.

The major histocompatibility complex class I (MHCI) trafficking signal (MITD) plays a pivotal role in enhancing the efficacy of mRNA vaccines. However, there was a lack of research investigating its efficacy in enhancing immune responses to RNA virus infections. Here, we have developed an innovative strategy for the formulation of mRNA vaccines.

Advancements of astaxanthin production in Haematococcus pluvialis: Update insight and way forward.

The global market demand for natural astaxanthin (AXT) is growing rapidly owing to its potential human health benefits and diverse industry applications, driven by its safety, unique structure, and special function. Currently, the alga Haematococcus pluvialis (alternative name H. lacustris) has been considered as one of the best large-scale producers of natural AXT.

Supportive care needs of the family caregivers of urostomy patients: a qualitative study.

Family caregivers play a vital role during the home care of urostomy patients by providing direct care and support. The role of family caregivers may extend to several years, even over ten years, in certain cases. In this process, the caregivers are impacted in various ways due to the patient's conditions and may not be able to identify and address their own needs, which often get ignored and remain unfulfilled.