Genomics insights of candidiasis: mechanisms of pathogenicity and drug resistance.

Candidiasis, a prevalent class of human infections caused by fungi belonging to the genus, is garnering increasing attention due to its pathogenicity and the emergence of drug resistance. The advancement of genomics technologies has offered powerful tools for investigating the pathogenic mechanisms and drug resistance characteristics of . This comprehensive review provides an overview of the applications of genomics in candidiasis research, encompassing genome sequencing, comparative genomics, and functional genomics, along with the pathogenic features and core virulence factors of .

Genetic Diversity Assessment and Core Germplasm Screening of Blackcurrant () in China via Expressed Sequence Tag-Simple Sequence Repeat Markers.

Blackcurrant ( L.) has high nutritional value for human health due to its abundant vitamin C, flavonoids, and organic acids. However, its breeding and genetic research have been severely hindered by the lack of scientific tools such as molecular markers.

Carbon quantum dots from fallen leaves of Lonicera caerulea L.: An innovative plant growth promoter and fruit quality enhancer.

With increasing environmental pollution and resource wastage, utilizing waste for high-value applications has become crucial. This study explores the preparation of carbon dots (CDs) from blue honeysuckle leaves and their potential in enhancing plant photosynthesis. CDs derived from these leaves have a particle size of ∼2.

Phytochemicals Targeting Mitophagy to Treat Heart Diseases: Retrospective Insights and Prospective Directions.

Mitophagy is a process by which cells selectively eliminate damaged or dysfunctional mitochondria through the autophagy-lysosome pathway, thereby maintaining mitochondrial quality and cellular homeostasis. This process is closely linked to the onset and progression of various heart diseases. Modern pharmacological research has demonstrated that phytochemicals can regulate mitochondrial homeostasis in cardiomyocytes through multiple mechanisms, influencing mitophagy and protecting cardiomyocytes, which in turn exerts anti-cardiovascular effects.

Long non-coding RNA Malat1 modulates CXCR4 expression to regulate the interaction between induced neural stem cells and microglia following closed head injury.

Background: Closed head injury (CHI) provokes a prominent neuroinflammation that may lead to long-term health consequences. Microglia plays pivotal and complex roles in neuroinflammation-mediated neuronal insult and repair following CHI. We previously reported that induced neural stem cells (iNSCs) can block the effects of CXCL12/CXCR4 signaling on NF-κB activation in activated microglia by CXCR4 overexpression.

Establishment and validation of a nomogram for coronary artery lesions in children with Kawasaki disease.

Background: The nomogram is a powerful and robust tool in disease risk prediction that summarizes complex variables into a visual model that is interpretable with a quantified risk probability. In the current study, a nomogram was developed to predict the occurrence of coronary artery lesions (CALs) among patients with Kawasaki disease (KD). This is especially valuable in the early identification of the risk of CALs, which will lead to proper diagnosis and treatment to reduce their associated complications.

LcMYB5, an R2R3-MYB family gene from Lonicera caerulea L., enhances drought and salt tolerance in transgenic tobacco and blue honeysuckle.

MYB transcription factors exert crucial functions in enhancing plant stress tolerance, which is impacted by soil drought and salinity. In our study, the R2R3-type MYB transcription factor gene LcMYB5 from blue honeysuckle (Lonicera caerulea L.) was successfully cloned and identified, and confirmed its nuclear localization.

Symptoms can predict COVID-19 pneumonia in patients infected with SARS-CoV-2 Omicron variants.

Pneumonia is a key criterion for the severity of COVID-19. Whether COVID-19 symptoms are indicators of pneumonia in patients infected with SARS-CoV-2 Omicron variants is unclear. 6200 non-hospitalized patients with COVID-19 from three sites in three hospitals were divided into three cohorts: Cohort 1 (n = 1971, Outpatient Department), Cohort 2 (n = 1073, Emergency Department), and Cohort 3 (n = 3156, Fever Clinic).

Chinese Clinical Named Entity Recognition With Segmentation Synonym Sentence Synthesis Mechanism: Algorithm Development and Validation.

Background: Clinical named entity recognition (CNER) is a fundamental task in natural language processing used to extract named entities from electronic medical record texts. In recent years, with the continuous development of machine learning, deep learning models have replaced traditional machine learning and template-based methods, becoming widely applied in the CNER field. However, due to the complexity of clinical texts, the diversity and large quantity of named entity types, and the unclear boundaries between different entities, existing advanced methods rely to some extent on annotated databases and the scale of embedded dictionaries.

Comparative evaluation of physiological and molecular responses of blackcurrant varieties to powdery mildew infection.

The black currant ( L.), a member of the Saxifragaceae family's genus, has gained consumer and grower acceptance due to its high nutritional value and economic potential. However, powdery mildew, the primary leaf disease affecting black currants, significantly impacts growers and the industry.

A patent review of SCF E3 ligases inhibitors for cancer：Structural design, pharmacological activities and structure-activity relationship.

Currently, as the largest family of E3 ubiquitin ligases, Skp1-Cullin 1-F-box (SCF) E3 ligase complexes have attracted extensive attention. Among SCF complexes, Skp2, β-TrCP, and FBXW7 have undergone extensive research on their structures and functions. Previous studies suggest Skp2, β-TrCP, and FBXW7 are overexpressed in numerous cancers.

Astragali radix (Huangqi): a time-honored nourishing herbal medicine.

Astragali radix (AR, namded Huangqi in Chinese) is the dried root of Astragalus membranaceus (Fisch.) Bge. var.

Effects of Drought Stress on Photosynthesis and Chlorophyll Fluorescence in Blue Honeysuckle.

Blue honeysuckle ( L.) is a deciduous shrub with perennial rootstock found in China. The objectives of this study were to explore the drought tolerance of blue honeysuckle, determine the effect of drought stress on two photosystems, and examine the mechanism of acquired drought tolerance.

Bio-pump cadmium phytoextraction efficiency promoted by phytohormones in Festuca arundinacea.

The leaves of Festuca arundinacea can excrete cadmium (Cd) out onto the leaf surface, leading to a bio-pump phytoremediation strategy based on "root uptake-root-to-leaf translocation-leaf excretion". However, the bio-bump efficiency of soil Cd is a limiting factor for the implementation of this novel technology. Bio-bump remediation involves the bioprocess of plant root uptake from soil, root-to-leaf translocation, and leaf hydathode excretion.

Resource allocation of cognitive relay networks under continuous transmission mechanism.

This paper considers the joint power allocation, path selection and subcarrier pairing design of cognitive radio cooperative networks, where the transmission power of secondary users is limited by its own power budget and the tolerable interference threshold of primary users. In particular, a continuous transmission mechanism rather than intermittent emission, leading to severe signal interference between primary and secondary users, as well as mutual interference between secondary users, is taken into account. This cooperative cognitive radio network is seen as an improvement in the sense that the source transmitter can continuously transmit symbols without silence.

Functional properties, structural characteristics, and anti-complementary activities of two degraded polysaccharides from strawberry fruits.

Two low-molecular-weight polysaccharides (DPSP50 and DPSP70) were obtained using hydrogen peroxide-vitamin C (HO-Vc) treatment at 50 °C and 70 °C, respectively. Both DPSP50 and DPSP70 comprised the same six monosaccharides in different ratios, and their molecular weights (Ms) were 640 kDa and 346 kDa, respectively. Functional properties analyses demonstrated that DPSP50 and DPSP70 each had an excellent water holding capacity, oil absorption capacity, and emulsion properties, as well as shear-thinning characteristics and viscoelastic properties.

Seeing is believing: what is on the surface of silver nanocrystals suspended in their original reaction solution.

Colloidal synthesis of inorganic nanocrystals always involves a multitude of ionic and molecular species. How the chemical species affect the evolution of nanocrystals remains a black box. As an essential ingredient in the polyol synthesis of Ag nanocubes, Cl has been proposed to co-adsorb on the surface with poly(vinyl pyrrolidone) (PVP) to facilitate shape evolution.

Deciphering cuproptosis-related signatures in pediatric allergic asthma using integrated scRNA-seq and bulk RNA-seq analysis.

Objective: Allergic asthma (AA) is common in children. Excess copper is observed in AA patients. It is currently unclear whether copper imbalance can cause cuproptosis in pediatric AA.

Evaluation of Blue Honeysuckle Berries ( L.) Dried at Different Temperatures: Basic Quality, Sensory Attributes, Bioactive Compounds, and In Vitro Antioxidant Activity.

This study aims to comprehensively investigate the effects of hot-air dehydration on the quality of blue honeysuckle berries ( L.). The results demonstrated that drying with hot air at 40-65 °C for 7-72 h resulted in blue honeysuckle berries with a moisture content of 0.

Effects of Aloe Gel on Lactating Women with Nipple Trauma.

To investigate the efficacy of aloe gel in reducing pain and promoting wound healing in postpartum women with nipple trauma. There were 80 postpartum women who took part in this study having developed nipple trauma during breastfeeding in the obstetrics department of a tertiary grade A hospital in Suzhou from January to December 2021. Postpartum women with nipple trauma whose hospital bed numbers ranged between 15 and 33 were included in the test group, whereas those whose hospital bed numbers ranged between 35 and 53 were included in the control group.

Recent development of VEGFR small molecule inhibitors as anticancer agents: A patent review (2021-2023).

VEGFR, a receptor tyrosine kinase inhibitor (TKI), is an important regulatory factor that promotes angiogenesis and vascular permeability. It plays a significant role in processes such as tumor angiogenesis, tumor cell invasion, and metastasis. VEGFR is mainly composed of three subtypes: VEGFR-1, VEGFR-2, and VEGFR-3.