A smartphone-assisted test paper fluorescence sensing platform for visual detection of α-Ketoglutaric acid based on Metal-Organic frameworks.

Developing an accurate, sensitive and visual strategy for quickly identifying biomarkers α-ketoglutaric acid (α-KA) is crucial for early disease diagnosis. Herein, we introduce a new fluorescence material, Eu@COMOC-4, synthesized by post-synthesis modification of a lanthanide-functionalized metal-organic frameworks (MOFs). This material serves as a visual fluorescence sensor to detect α-KA, with a distinct fluorescence response.

A Thermo-Electro-Viscoelastic Model for Dielectric Elastomers.

Dielectric elastomers (DEs) are a class of electro-active polymers (EAPs) that can deform under electric stimuli and have great application potential in bionic robots, biomedical devices, energy harvesters, and many other areas due to their outstanding deformation abilities. It has been found that stretching rate, temperature, and electric field have significant effects on the stress-strain relations of DEs, which may result in the failure of DEs in their applications. Thus, this paper aims to develop a thermo-electro-viscoelastic model for DEs at finite deformation and simulate the highly nonlinear stress-strain relations of DEs under various thermo-electro-mechanical loading conditions.

Synthesis and characterization of rare-earth metallate amido complexes bearing the 2-amidate-functionalized indolyl ligand and their application in the hydroboration of esters with pinacolborane.

The reactions of 2-amidate-functionalized indolyl proligand 2-(2,6-PrCHNHCO)CHNH (HL) with [(MeSi)N]RE(μ-Cl)Li(THF) were studied leading to the synthesis and characterization of a series of novel discrete trinuclear rare-earth metallate amido complexes containing the anion [{η:(μ-η:η):η-LREN(SiMe)}(μ-Cl)] and cation Li(THF) (RE = Y(1a), Nd (1b), Sm (1c), Gd (1d), Dy (1e), Er (1f), and Yb (1g)) in good yields by silylamine elimination. All of the complexes were characterized by spectroscopic methods, elemental analyses and single-crystal X-ray diffraction, and complexes 1a and 1c were additionally characterized by NMR spectroscopy. As proof of principle of their activity, these complexes were used as precatalysts for the hydroboration of esters using HBpin as the hydride source displaying high activity under neat and room temperature conditions.

The hit of the novel coronavirus outbreak to China's economy.

Broke out at the end of 2019, the novel coronavirus pneumonia (COVID-19) has been spreading throughout the world, leading to more than 87 million confirmed infections and 1.88 million fatalities. Motivated by this, we evaluate the economic impacts of COVID-19 outbreak on both national and industrial levels by employing quarterly computable general equilibrium (CGE) model.

Cold Plasma Irradiation Regulates Inflammation and Oxidative Stress in Human Bronchial Epithelial Cells and Human Non-Small Cell Lung Carcinoma.

Atmospheric pressure cold plasma has shown multiple biological effects of anti-bacteria and anti-cancer. In this study, the effect of atmospheric pressure cold plasma on respiratory inflammation and oxidant stress is explored. Tunicamycin was used to stimulate human bronchial epithelial cells (HBECs) and A549 cells for inflammatory response and oxidative stress, followed by atmospheric pressure cold plasma treatment.

Mono-macrophage-Derived MANF Alleviates Bacterial Myocarditis by Inhibiting NF-kappaB Activation and Myocardial Inflammation.

Bacterial myocarditis is a key cause leading to myocardial damage and cardiac dysfunction. Mesencephalic astrocyte-derived neurotrophic factor (MANF) has been found to be an anti-inflammatory factor. This study is to explore the effect of MANF on LPS-induced myocardial inflammation and macrophage differentiation.

Mono-macrophage-Derived MANF Protects Against Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting Inflammation and Renal M1 Macrophages.

The outburst of renal inflammatory response has been found to be a crucial cause of acute kidney injury (AKI). Attenuating the renal inflammation is an effective way for AKI treatment. Mesencephalic astrocyte-derived neurotrophic factor (MANF) has been proven to be an anti-inflammatory factor.

Innate lymphoid cells regulate radiation-induced skin damage via CCR10 signaling.

Objective: To assess the role of CCR10 in innate lymphoid cells (ILCs) response in radiation-induced skin damage.

Material And Methods: CCR10 and CCR10 mice were treated with either a single dose of 5 Gy or 5 Gy everyday for 6 days with a total dose of 30 Gy with X-ray. ILCs from the skin were isolated and analyzed by flow cytometry 3 and 10 days after irradiation.

[Potential for Phosphorus Uptake by Bed Sediments and Its Response to Carbon Additions in the Shiwuli River, Chaohu Lake Basin].

Surficial sediments were collected from five sampling sites in the mainstream of the Shiwuli River along an urban-rural gradient in the Chaohu Lake basin during July 2017 (summer) and January 2018 (winter). The total uptake (SPU), abiotic uptake (SPU), and biotic uptake (SPU) of phosphorus by sediments were measured, and uptake responses to different carbon sources (i. e.

Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Negatively Correlates With Atrial Apoptosis in Human Chronic Atrial Fibrillation.

Atrial apoptosis has been found to be majorly involved in the pathogenesis of human atrial fibrillation (AF). Mesencephalic astrocyte-derived neurotrophic factor exerts an antiapoptotic effect for multiple cell types. However, the correlation between MANF and atrial apoptosis in AF is still undefined.

[Effects of Exogenous Carbon Addition on Equilibrium Phosphate Concentration and Risk of Phosphorus Release from Sediments in the Shiwuli River, Chaohu Lake Basin].

Five surface sediment samples were collected every two months from the Shiwuli River along an urban-rural gradient, Chaohu Lake Basin, from July 2017 to May 2018. Sediment phosphorus fractions were investigated, and equilibrium phosphate concentration (EPC) and its response to exogenous carbon (sodium acetate) addition were explored. Moreover, the risk of phosphorus release from sediment into water column was also evaluated.

Multiple-input multiple-output synthetic aperture ladar system for wide-range swath with high azimuth resolution.

For the trade-off between the high azimuth resolution and the wide-range swath in the single-input single-output synthetic aperture ladar (SAL) system, the range swath of the SAL system is restricted to a narrow range, this paper proposes a multiple-input multiple-output (MIMO) synthetic aperture ladar system. The MIMO system adopts a low pulse repetition frequency (PRF) to avoid a range ambiguity for the wide-range swath and in azimuth adopts the multi-channel method to achieve azimuth high resolution from the unambiguous azimuth wide-spectrum signal, processed through adaptive digital beam-forming technology. Simulations and analytical results are presented.

[Study on the content of curcumin by HPLC and the anti-tumor effect in vivo from different processed products of Curuma kwangsiensis].

Objective: To determine curcumin content by HPLC and observe the antitumor effects in vivo from different processed products of Curuma kwangsiensis.

Methods: We determined the content of curcumin by HPLC from different processed products of Curuma kwangsiensis and studied the anti-tumor effects in vivo by establishing S180 transplanted tumors model in mice.

Results: The content of curcumin in different processed products of Curuma kwangsiensis as follows: primitive > vinegar-fried > vinegar-cooked.

[Naphtha analysis of different processed products of Rhizoma Curcumae from Guangxi by GC-MS].

Objective: To approach the naphtha analysis of different processed products of Rhizoma Curcumae from Guangxi.

Methods: The naphtha was extracted by steam distillation. The relative content of every compound was determined with area normalization method and the structures were elucidated by GC-MS technique.

Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy.

Lung cancer is one of the leading causes of death with one of the lowest survival rates. However, a subset of lung cancer patients who are of Asian origin and carry somatic mutations in epidermal growth factor receptor or EGFR have responded remarkable well to two tyrosine kinase inhibitors, gefitinib and erlotinib. While EGFR mutation profiles have been reported from Japan, South Korea, and Taiwan, there is no such report from mainland of China where the largest pool of patients reside.