Early coagulation changes as predictors of adverse outcomes in patients with severe burn and inhalation injuries.

Background: Disorders of the coagulation pathway are triggered in patients with severe burn and inhalation injuries in the early stages. There are multiple early coagulation indices identified to correlate with adverse outcomes.

Method: A retrospective analysis of patients with severe burn and inhalation injuries from 12 centers in mainland China was performed to identify early changed coagulation indices with predictive value associated with four major 28-day adverse outcomes (death, anticoagulation, mechanical ventilation, continuous renal replacement therapy) by logistic regression.

Association between hemoglobin and in-hospital mortality in critically ill patients with sepsis: evidence from two large databases.

Background: The relationship between baseline hemoglobin levels and in-hospital mortality in septic patients remains unclear. This study aimed to clarify this association in critically ill patients with sepsis.

Methods: Patients with sepsis were retrospectively identified from the Medical Information Mart for Intensive Care-IV (MIMIC-IV 2.

Factors and machine learning models for predicting successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury: a retrospective cohort study based on MIMIC-IV database.

Background: For critically ill patients with acute kidney injury (AKI), there remains controversy regarding the predictive factors affecting the discontinuation of continuous renal replacement therapy (CRRT). This study aims to explore factors associated with successful CRRT discontinuation in AKI patients and to develop predictive models for successful discontinuation.

Methods: We conducted a retrospective study on adult patients with AKI who received CRRT, sourced from the Medical Information Mart for Intensive Care (MIMIC-IV) database.

The value of Age-adjusted Charlson and Elixhauser-Van Walraven comorbidity index in predicting prognosis for patients undergoing heart valve surgery.

Objective: This study aims to compare the efficacy of the Age-adjusted Charlson Comorbidity Index (ACCI) and the Elixhauser-Van Walraven Comorbidity Index (ECI-VW) in predicting mortality risk among patients undergoing heart valve surgery.

Methods: Clinical data were extracted from the INSPIRE Database using R language. The Receiver Operating Characteristic (ROC) Curve was employed to assess the predictive accuracy of ACCI and ECI-VW for in-hospital all-cause mortality and post-surgical all-cause mortality at 7 and 28 days.

The global, regional, and national burden of burns: An analysis of injury by fire, heat, and hot substances in the global burden of disease study 2019.

Background: Burn caused by exposure to hot substances is a common occurrence but there is little data on prevalence trends and disease burden. This research report the burden of burn injuries globally, regionally, and nationally from 1990 to 2019, identify hotspots, and analyze factors affecting disease burden with data from Global Burden of Disease 2019 survey.

Methods: The Global Burden of Disease 2019 estimated the incidence, death rate, and disease-adjusted life years (DALY) for injuries due to exposure to fire, heat, and hot substances from 1990 to 2019.

Alterations in novel inflammatory biomarkers during perioperative cardiovascular surgeries involving cardiopulmonary bypass: a retrospective propensity score matching study.

Background: Cardiopulmonary bypass (CPB) triggers a strong inflammatory response in cardiovascular surgery patients during the perioperative period. This article mainly focuses on the perioperative application of novel inflammatory biomarkers in cardiovascular surgeries involving CPB.

Methods: Patients were divided into a CPB group and a non-CPB group according to whether they underwent CPB during cardiovascular surgery.

Advances in photodynamic therapy of pathologic scar.

Pathologic scars include keloids and hypertrophic scars due to abnormal wound healing. Both cause symptoms of itching and pain; they also affect one's appearance and may even constrain movement. Such scars place a heavy burden on the individual's physical and mental health; moreover, treatment with surgery alone is highly likely to leave more scarring.

Application progress of single-cell sequencing technology in mesenchymal stem cells research.

Single-Cell Sequencing (SCS) technology plays an important role in the field of Mesenchymal Stem Cells (MSCs) research. This paper comprehensively describes the application of SCS technology in the field of MSCs research, including (1) SCS enables more precise MSCs characterization and biomarker definition. (2) SCS reveals the prevalent gene expression heterogeneity among different subclusters within MSCs, which contributes to a more comprehensive understanding of MSCs function and diversity in developmental, regenerative, and pathological contexts.

A Bibliometric Analysis of the Trends and Evolution on Inhalation Injury Research.

Inhalation injury is a common complication in burn patients and is also a factor that can affect the multiple prognoses of burn patients. Attention to inhalation injury began early globally, but few articles have systematically analyzed its development. We employed bibliometric methods to analyze articles on inhalation injury published in 3 medical databases.

China's strictest water policy: Reversing water use trends and alleviating water stress.

Growing water problems have promoted the Chinese government to implement the strictest water resources management system (SWRMS), the first national policy that puts into practice the concept of "safe operating space" for human water use. Here, we investigate the impact of the SWRMS on China's water use and water stress based on a newly compiled high-resolution and multi-sectoral water use dataset. Results indicate that China's total water use (TWU) increased significantly from 549 km yr to 610 km yr between 2000 and 2012 (i.

Gut Microbiota and Respiratory Infections: Insights from Mendelian Randomization.

The role of the gut microbiota in modulating the risk of respiratory infections has garnered increasing attention. However, conventional clinical trials have faced challenges in establishing the precise relationship between the two. In this study, we conducted a Mendelian randomization analysis with single nucleotide polymorphisms employed as instrumental variables to assess the causal links between the gut microbiota and respiratory infections.

[Correlation between blood pressure indexes and prognosis in sepsis patients: a cohort study based on MIMIC-III database].

Objective: To investigate the correlation between early-stage blood pressure indexes and prognosis in sepsis patients.

Methods: A retrospective cohort study was conducted on the medical records of patients diagnosed with sepsis from 2001 to 2012 in the Medical Information Mart for Intensive Care-III (MIMIC-III) database. Patients were divided into survival group and death group according to the 28-day prognosis.

Combination of transcriptional biomarkers and clinical parameters for early prediction of sepsis indued acute respiratory distress syndrome.

Objective: As a common yet intractable complication of severe sepsis, acute respiratory distress syndrome (ARDS) is closely associated with poor clinical outcomes and elevated medical expenses. The aim of the current study is to generate a model combining transcriptional biomarkers and clinical parameters to alarm the development of ARDS in septic patients.

Methods: Gene expression profile (GSE66890) was downloaded from the Gene Expression Omnibus database and clinical data were extracted.

Clinical evaluation of high-intensity focused ultrasound ablation combined with mifepristone and levonorgestrel-releasing intrauterine system to treat symptomatic adenomyosis.

Objective: To evaluate the clinical efficacy of the combination of high-intensity focused ultrasound (HIFU), mifepristone, and levonorgestrel-releasing intrauterine system (LNG-IUS) in adenomyosis treatment.

Methods: HIFU treatment was performed in 123 patients with symptomatic adenomyosis who had refused treatment with gonadotropin-releasing hormone agonist (GnRH-a) at Anyang Maternal and Child Health Care Hospital. In the control group, 34 patients were treated with HIFU alone, 29 patients with HIFU combined with mifepristone, 10 patients with HIFU combined with LNG-IUS.

[Research progress of mesenchymal stem cells and their derivatives nebulization in the treatment of pulmonary diseases].

In acute or chronic lung diseases, inappropriate immune response and abnormal repair process can lead to irreversible damage to lung tissue, which in turn leads to decreased lung function and even respiratory failure or death. Mesenchymal stem cells (MSCs) and their derivatives have shown wide application prospects in cell therapy and acellular therapy of lung diseases and are entering the clinical transformation stage because of their unique physiological functions and characteristics, but the safety and efficacy of MSCs and their derivatives are still controversial. Nebulization therapy provides new opportunities and challenges for the innovative treatment of MSCs and their derivatives in lung diseases.

Transient Budd-Chiari syndrome secondary to blunt traumatic bile fistula: A case report.

Budd-Chiari syndrome (BCS) is rarely caused by trauma. We reported a case of transient and secondary BCS post polytrauma that resulting from massive perihepatic and abdominal fluid and compressed liver, causing stenosis of the inferior vena cava and hepatic veins. This was a special BCS case related to but not directly caused by trauma.

Process optimization of polyphenol oxidase immobilization: Isotherm, kinetic, thermodynamic and removal of phenolic compounds.

Chitosan/montmorillonite (CTS/MMT) and chitosan‑gold nanoparticles/montmorillonite (CTS-Au/MMT) composites were prepared, characterized through Fourier transformed infrared (FT-IR), X-ray powder diffraction (XRD), and scanning electron microscopy (SEM), and utilized as support for immobilization of polyphenol oxidase (PPO). PPO was immobilized on CTS/MMT (IPPO) and CTS-Au/MMT (IPPO-Au) by physical adsorption, respectively. In order to achieve simultaneous maximization of immobilization efficiency and enzyme activity, the immobilization process parameters were optimized by Taguchi-Grey relational analysis (TGRA) approach.

Immobilization of polyphenol oxidase on chitosan/organic rectorite composites for phenolic compounds removal.

Chitosan/organic rectorite (CTS/OREC) composites were prepared and characterized by Fourier transform infrared spectrometry and X-ray diffraction. Polyphenol oxidase (PPO) was immobilized on CTS/OREC by physical adsorption (APPO) and covalent binding (CPPO). Taguchi method was applied in the optimization of immobilization conditions resulting in the highest enzyme activity of 16.

Immobilized polyphenol oxidase: Preparation, optimization and oxidation of phenolic compounds.

Polyphenol oxidase (PPO) was immobilized on chitosan/montmorillonite (CTS/MMT) and chitosan-gold nanoparticles/montmorillonite (CTS-AuNPs/MMT) composites, respectively. Taguchi method was applied to determine the optimal immobilization conditions for achieving the maximum enzyme activity. PPO immobilized on CTS/MMT (IPPO) and CTS-AuNPs/MMT (IPPO-Au) showed the highest enzyme activity at 15.

An in vitro comparison of the antioxidant activities of chitosan and green synthesized gold nanoparticles.

Gold nanoparticles (AuNPs) were synthesized using chitosan with different degree of deacetylation (DD) and molecular weight (MW) as reducing agent and stabilizer. The synthesized AuNPs were characterized by UV-vis spectroscopy, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffractometer (XRD). The OH, ABTS and DPPH scavenging activity and ferric reducing antioxidant power (FRAP) of chitosan, synthesized AuNPs and Au colloids were determined through in vitro assays.

Size controllable one step synthesis of gold nanoparticles using carboxymethyl chitosan.

Gold nanoparticles (AuNPs) were synthesized by reducing chloroauric acid with nontoxic and biodegradable carboxymethyl chitosan (CMC) as dual roles of reducing agent and stabilizer. Several CMC with different molecular parameters, i.e.

One pot synthesis of gold nanoparticles using chitosan with varying degree of deacetylation and molecular weight.

Gold nanoparticles (AuNPs) were synthesized in one-step by reducing gold salt using nontoxic and biodegradable chitosan as dual roles of reducing agent and stabilizer. The obtained AuNPs were characterized with UV-vis spectroscopy and transmission electron microscopy. The results indicated that control over the size and shape of AuNPs is achieved through the careful selection of experimental conditions, such as reaction temperature, reaction time, concentration of gold salt and chitosan, and chitosan molecular parameters, i.

Effect of seawater salinity on pore-size distribution on a poly(styrene)-based HP20 resin and its adsorption of diarrhetic shellfish toxins.

In the present study, okadaic acid (OA) and dinophysistoxin-1 (DTX1) were spiked into artificial seawater at low, medium and high estuarine salinities (9‰, 13.5‰ and 27‰). Passive samplers (HP20 resin) used for solid phase adsorption toxin tracking (SPATT) technology were exposed in these seawaters for 12-h periods.

Modeling total maximum allocated loads for heavy metals in Jinzhou Bay, China.

With the recent development of society and economy in the cities of Huludao and Jinzhou, Liaoning Province, China, environment and ecosystem problems have become increasingly serious in Jinzhou Bay, China, because of the increasing amount of heavy metal pollutants being discharged. To solve these problems, a water quality model of heavy metals coupled with a 3D hydrodynamic model is constructed to estimate the environmental capacity (EC) and total maximum allocated loads (TMALs) for Zn and Cd of three river catchments in Jinzhou Bay. According to the model, the ECs for Zn and Cd are approximately 17 and 8 tons per month, respectively, if the criterion obtained from HC5 values (fifth percentile of the SSD) is set as the control criterion (8.