Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
November 2024
Front Cell Dev Biol
December 2021
The mechanisms underlying neutrophilic inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) remain poorly investigated. This study aimed to examine the factors that contribute to tissue neutrophilia in CRSwNP. The numbers of neutrophils and active caspase-3-positive apoptotic neutrophils in sinonasal tissues were assessed via immunofluorescence staining.
View Article and Find Full Text PDFBackground: The impacts of chronic airway diseases on coronavirus disease 2019 (COVID-19) are far from understood.
Objective: To explore the influence of asthma and chronic obstructive pulmonary disease (COPD) comorbidity on disease expression and outcomes, and the potential underlying mechanisms in COVID-19 patients.
Methods: A total of 961 hospitalized COVID-19 patients with a definite clinical outcome (death or discharge) were retrospectively enrolled.
Background: The mechanisms underlying mucosal eosinophilia in chronic rhinosinusitis with nasal polyps (CRSwNP) remain poorly clarified. The nervous system and neuropeptides play an important role in the regulation of immune response. Herein we explore the expression and function of hemokinin-1 (HK-1), a newly identified tachykinin, along with its receptor neurokinin 1 receptor (NK1R) in CRSwNP.
View Article and Find Full Text PDFJ Allergy Clin Immunol
November 2018
Background: Although upregulated expression of local IgD has been reported in patients with chronic rhinosinusitis (CRS), its function is unclear.
Objective: We sought to explore the expression and function of soluble IgD in patients with CRS, particularly CRS with nasal polyps.
Methods: IgD levels in sinonasal mucosa were analyzed by using RT-PCR and ELISA.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
November 2015