Objectives: The protective role of sodium glucose cotransporter 2 (SGLT2) inhibitors in renal outcomes has been revealed by large cardiovascular outcome trials among patients with type 2 diabetes. However, the effect of SGLT2 inhibitors on lupus nephritis (LN) and its underlying mechanisms remain unknown.
Methods: We applied empagliflozin treatment to lupus-prone MRL/ mice to explore the renal protective potential of SGLT2 inhibitors.
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging (known as immunosenescence). During aging, organisms tend to develop a characteristic inflammatory state that expresses high levels of pro-inflammatory markers, termed inflammaging. This chronic inflammation is a typical phenomenon linked to immunosenescence and it is considered the major risk factor for age-related diseases.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
February 2018
A group of color tunable SrLaNa(PO)F:Tb,Eu phosphors were prepared by conventional high temperature solid state method. The phase structures, luminescence properties, fluorescence lifetimes and energy transfer were investigated in detail. Under 369nm excitation, owing to efficient energy transfer of Tb→Eu, the emission spectra both have green emission of Tb and red emission of Eu.
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