Publications by authors named "Qimei Yu"
Background: Lung cancer is the leading cause of malignancy-related mortality and lung adenocarcinoma accounts for about 40% of lung malignancies. The aim of this study was to investigate the associations of intraflagellar transport protein 20 (IFT20) and Golgi matrix protein 130 (GM130) expression with clinicopathological features and survival in patients with lung adenocarcinoma.
Methods: The expressions of IFT20 and GM130 protein in cancerous and matched adjacent lung tissues of 235 patients with lung adenocarcinoma were assessed by tissue microarray and immunohistochemistry, which were indicated by the mean optical density (IOD/area), the rate of positive staining cells and staining intensity score.
Carbon black nanoparticles induce HDAC6-mediated inflammatory responses in 16HBE cells.
Toxicol Ind Health
October 2020
Long-term inhalation of carbon black nanoparticles (CBNPs) leads to pulmonary inflammatory diseases. Histone deacetylase 6 (HDAC6) has been identified as an important regulator in the development of inflammatory disorders. However, the direct involvement of HDAC6 in CBNPs-induced pulmonary inflammatory responses remains unclear.
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- Impaired mucociliary clearance is linked to recurrent cough and respiratory diseases, and this study investigates how inhaled silica particles affect this system.
- Mice were exposed to silica particles, and subsequent evaluations showed significant damage to the mucociliary structure, including disordered cilia and increased mucus production over time.
- Findings revealed that while silica exposure reduced MUC5B expression on airway surfaces, it increased production in submucosal glands, suggesting that these changes may contribute to silica-related respiratory illnesses.
Article Synopsis
- Prolonged exposure to crystalline silica causes serious lung issues, and CTGF (Connective Tissue Growth Factor) plays a significant role in inflammation and fibrosis but its specific impact under silica exposure is not well-known.
- Research involved knocking down CTGF in human bronchial epithelial cells exposed to different concentrations of silica, measuring changes in CTGF expression and inflammatory cytokine levels.
- Results showed that silica increases CTGF expression and associated inflammatory cytokines in a dose-dependent manner, and inhibiting CTGF reduces this inflammation, suggesting it’s crucial in silica-induced lung damage.