A novel network pharmacology strategy to decode mechanism of Wuling Powder in treating liver cirrhosis.

Background: Liver cirrhosis is a chronic liver disease with hepatocyte necrosis and lesion. As one of the TCM formulas Wuling Powder (WLP) is widely used in the treatment of liver cirrhosis. However, it's key functional components and action mechanism still remain unclear.

Screening of the key response component groups and mechanism verification of Huangqi-Guizhi-Wuwu-Decoction in treating rheumatoid arthritis based on a novel computational pharmacological model.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the destruction of synovial tissue and articular cartilage. Huangqi-Guizhi-Wuwu-Decoction (HGWD), a formula of Traditional Chinese Medicine (TCM), has shown promising clinical efficacy in the treatment of RA. However, the synergistic effects of key response components group (KRCG) in the treatment of RA have not been well studied.

Extremely wideband low-RCS polarization conversion metasurface based on multivariate phase destructive interference.

In this paper, a polarization modulated metasurface to improve the magnitude and expand the bandwidth of radar cross section (RCS) reduction is presented. Two physical mechanisms are responsible for the reflection diffusion of the proposed metasurface. One is the functionality of controlling the spatial distribution of polarization response, and the other is the capability of spanning the entire 2π phase range by making full use of the variable sizes and height difference of unit cells to achieve superwideband phase cancellation.

Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress.

Psychological stress is well known to increase colitis susceptibility and promote relapse. Metabolic changes are commonly observed under psychological stress, but little is known how this relates to the progression of colitis. Here we show that kynurenic acid (KA) is an endogenous driver of social stress-exacerbated colitis via regulating the magnitude of NLRP3 inflammasome.