Publications by authors named "Qilan Hong"
The nucleosome remodeling and histone deacetylase (NuRD) complex physically associates with BCL11B to regulate murine T-cell development. However, the function of NuRD complex in mature T cells remains unclear. Here, we characterize the fate and metabolism of human T cells in which key subunits of the NuRD complex or BCL11B are ablated.
View Article and Find Full Text PDFOur understanding of human hepatocellular carcinoma (HCC) development and progression has been hampered by the lack of in vivo models. We performed a genetic screen of 10 oncogenes and genetic mutations in Fah-ablated immunodeficient mice in which primary human hepatocytes (PHHs) are used to reconstitute a functional human liver. We identified that MYC, TP53 , and KRAS are highly expressed in induced HCC (iHCC) samples.
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- Scientists are working on a new cancer treatment called adoptive cell therapy (ACT) that uses special T cells and natural killer (NK) cells to fight tumors, especially solid tumors, which are harder to treat.
- They experimented with a gene-editing tool called CRISPR to change human T cells, which helped turn them into a new type of cell called induced T-to-natural killer cells (ITNKs) that can better attack cancer.
- In early tests on patients with hard-to-treat cancers, these ITNKs were found to be safe and showed some positive effects, making them a promising option for future cancer therapies.
High-risk HPV is clearly associated with cervical cancer. HPV integration has been confirmed to promote carcinogenesis in the previous studies. In our study, a total of 285 DNA breakpoints and 287 RNA breakpoints were collected.
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