AQP1 mediates pancreatic β cell senescence induced by metabolic stress through modulating intracellular HO level.

Metabolic stress-induced pancreatic β cell senescence plays a pivotal role in the type 2 diabetes progression, and yet the precise molecular mechanisms remain elusive. Through cellular experiments and bioinformatics analyses, we identified aquaporin 1(AQP1)-mediated transmembrane transport of hydrogen peroxide as a key driver of glucolipotoxicity-induced senescence in MIN6 cells. A PPI network analysis was used to cross-reference 17 differentially expressed genes associated with type 2 diabetes from three independent GEO databases with 188 stress-induced senescence-related genes from CellAge.

Therapeutic potential of ghrelin/GOAT/GHSR system in gastrointestinal disorders.

Ghrelin, a peptide primarily secreted in the stomach, acts via the growth hormone secretagogue receptor (GHSR). It regulates several physiological processes, such as feeding behavior, energy homeostasis, glucose and lipid metabolism, cardiovascular function, bone formation, stress response, and learning. GHSR exhibits significant expression within the central nervous system.

Cytokines: The links between bone and the immune system.

Osteoporosis results from an imbalance in a highly balanced physiological process called bone remodeling, in which osteoclast-mediated bone resorption and osteoblast-mediated bone formation play important roles. Osteoimmunology is a newly discovered interdisciplinary research field that focuses on the relationship between bone and the immune system. Specifically, bone and the immune system interact through cytokines, immune cells secrete cytokines, and cytokines finely regulate bone metabolism by mediating the differentiation and activity of osteoclasts and osteoblasts.

Sarcopenia and COVID-19 Outcomes.

Coronavirus disease 2019 (COVID-19) spread rapidly and became a severe global public health threat. Older adults have a high risk of COVID-19 and its associated mortality. Sarcopenia has emerged as a predictor of poor outcomes in COVID-19 patients, including lengthy hospital stays, mortality, intensive care unit admission, need for invasive mechanical ventilation, and poor rehabilitation outcomes.

New Advances in Improving Bone Health Based on Specific Gut Microbiota.

The gut microbiota has been shown to play an important role in the pathogenesis of various diseases, including metabolic diseases, cardiovascular diseases, and cancer. Recent studies suggest that the gut microbiota is also closely associated with bone metabolism. However, given the high diversity of the gut microbiota, the effects of different taxa and compositions on bone are poorly understood.

Immobilisation of high-arsenic-containing tailings by using metallurgical slag-cementing materials.

The mixture of finely ground blast furnace slag (BFS), basic oxygen furnace (BOF) steel slag (SS), and flue gas desulfurisation (FGD) gypsum could be used as cement to solidify heavy metals. In this study, these cementitious materials were combined with high-arsenic-containing tailings to form cemented backfill material (CBM). The results indicated that the optimal design of CBM was that of specimen CBM2 which showed good early strength (10.

Clinical effectiveness and influential factors of maxillary rehabilitation with zygomatic implant following tumor resection.

Objective: To evaluate the clinical effectiveness and influential factors of maxillary rehabilitation with zygomatic implant and prosthesis after tumor resection.

Methods: Thirty-six patients with maxillary defects were collected prospectively in this study and received zygomatic implant and prosthesis for maxillary rehabilitation in the Department of Stomatology of the Municipal Hospital, Taizhou, Zhejiang, China from March 2007 to May 2010. The speech intelligibility (SI) and masticatory efficiency of pre-rehabilitation and post-rehabilitation at one, 6, 12, and 24 months were measured.